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- W3043173602 abstract "Abstract Ribosomal RNAs (rRNAs) are essential components of the ribosome and are among the most abundant macromolecules in the cell. To ensure high rRNA level, eukaryotic genomes contain dozens to hundreds of rDNA genes, however, only a fraction of the rRNA genes seems to be active, while others are transcriptionally silent. We found that individual rDNA genes have high level of cell-to-cell heterogeneity in their expression in Drosophila melanogaster . Insertion of heterologous sequences into rDNA leads to repression associated with reduced expression in individual cells and decreased number of cells expressing rDNA with insertions. We found that SUMO (Small Ubiquitin-like Modifier) and SUMO ligase Ubc9 are required for efficient repression of interrupted rDNA units and variable expression of intact rDNA. Disruption of the SUMO pathway abolishes discrimination of interrupted and intact rDNAs and removes cell-to-cell heterogeneity leading to uniformly high expression of individual rDNA in single cells. Our results suggest that the SUMO pathway is responsible for both repression of interrupted units and control of intact rDNA expression." @default.
- W3043173602 created "2020-07-23" @default.
- W3043173602 creator A5003412490 @default.
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- W3043173602 creator A5022440678 @default.
- W3043173602 creator A5052647374 @default.
- W3043173602 creator A5070942082 @default.
- W3043173602 date "2020-07-14" @default.
- W3043173602 modified "2023-09-28" @default.
- W3043173602 title "Repression of interrupted and intact rDNA by the SUMO pathway in<i>Drosophila melanogaster</i>" @default.
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