Matches in SemOpenAlex for { <https://semopenalex.org/work/W3043178839> ?p ?o ?g. }
- W3043178839 endingPage "33" @default.
- W3043178839 startingPage "25" @default.
- W3043178839 abstract "Background and objectivesAsarum europaeum L. is an herbal medicine belonging to the family Aristolochiaceae. The rhizome of the plant has been used for the treatment of various diseases in complementary and alternative medicine of various countries. In Iranian traditional medicine (ITM), the aqueous extract of the rhizome has been used for the improvement and enhancement of memory.MethodsIn the present study, the aqueous and hydroalcoholic extracts as well as different fractions of A. europaeum rhizome were evaluated for their cholinesterase (ChE), acetyl- and butyrylcholinesterase (AChE and BChE) inhibitory activity viamodified Ellman's method. ResultsThe ethyl acetate fraction selectively showed the most suitable anti-AChE activity (IC50 = 99.69 µg/mL); none of the extracts or fractions demonstrated anti-BChE activity. In this regard, the ethyl acetate fraction was candidate for the investigation of further biological activities such as antioxidant activity, neuroprotectivity, and metal chelating ability related to Alzheimer’s disease. It depicted favorable neuroprotectivity at concentration of 100 μg/mL against the toxicity of exposure to H2O2 in PC12 cells (p£0.001, cell viability = 80/60%) and chelating ability towards zinc, iron, and copper ions. The results of antioxidant activity by DPPH assay showed that the ethyl acetate fraction was much more potent than BHA as the reference drug.ConclusionThe ethyl acetate fraction ofA. europaeum L. showed potent biological activities involved in Alzheimer’s disease and needs complementary investigations to develop an herbal product against Alzheimer’s disease." @default.
- W3043178839 created "2020-07-23" @default.
- W3043178839 creator A5019395496 @default.
- W3043178839 creator A5036838121 @default.
- W3043178839 creator A5050208862 @default.
- W3043178839 creator A5051636891 @default.
- W3043178839 creator A5052984021 @default.
- W3043178839 creator A5056884443 @default.
- W3043178839 creator A5074901866 @default.
- W3043178839 date "2020-07-01" @default.
- W3043178839 modified "2023-09-26" @default.
- W3043178839 title "Evaluation of Asarum europaeum L. Rhizome for the Biological Activities Related to Alzheimer’s Disease" @default.
- W3043178839 cites W1977398572 @default.
- W3043178839 cites W1995262770 @default.
- W3043178839 cites W2039194462 @default.
- W3043178839 cites W2061730664 @default.
- W3043178839 cites W2084174305 @default.
- W3043178839 cites W2090496922 @default.
- W3043178839 cites W2113950441 @default.
- W3043178839 cites W2281220653 @default.
- W3043178839 cites W2407031382 @default.
- W3043178839 cites W2542856291 @default.
- W3043178839 cites W2610795807 @default.
- W3043178839 cites W2767061724 @default.
- W3043178839 cites W2915829877 @default.
- W3043178839 cites W2916416018 @default.
- W3043178839 cites W2918066696 @default.
- W3043178839 cites W3000635098 @default.
- W3043178839 cites W344966878 @default.
- W3043178839 cites W38098989 @default.
- W3043178839 doi "https://doi.org/10.22127/rjp.2020.223143.1565" @default.
- W3043178839 hasPublicationYear "2020" @default.
- W3043178839 type Work @default.
- W3043178839 sameAs 3043178839 @default.
- W3043178839 citedByCount "3" @default.
- W3043178839 countsByYear W30431788392021 @default.
- W3043178839 countsByYear W30431788392022 @default.
- W3043178839 crossrefType "journal-article" @default.
- W3043178839 hasAuthorship W3043178839A5019395496 @default.
- W3043178839 hasAuthorship W3043178839A5036838121 @default.
- W3043178839 hasAuthorship W3043178839A5050208862 @default.
- W3043178839 hasAuthorship W3043178839A5051636891 @default.
- W3043178839 hasAuthorship W3043178839A5052984021 @default.
- W3043178839 hasAuthorship W3043178839A5056884443 @default.
- W3043178839 hasAuthorship W3043178839A5074901866 @default.
- W3043178839 hasConcept C134550120 @default.
- W3043178839 hasConcept C181199279 @default.
- W3043178839 hasConcept C185592680 @default.
- W3043178839 hasConcept C2776789170 @default.
- W3043178839 hasConcept C2778004101 @default.
- W3043178839 hasConcept C2778816929 @default.
- W3043178839 hasConcept C2779059548 @default.
- W3043178839 hasConcept C2779101902 @default.
- W3043178839 hasConcept C2779858419 @default.
- W3043178839 hasConcept C2781401929 @default.
- W3043178839 hasConcept C31896038 @default.
- W3043178839 hasConcept C55493867 @default.
- W3043178839 hasConcept C556039675 @default.
- W3043178839 hasConcept C71924100 @default.
- W3043178839 hasConcept C98274493 @default.
- W3043178839 hasConceptScore W3043178839C134550120 @default.
- W3043178839 hasConceptScore W3043178839C181199279 @default.
- W3043178839 hasConceptScore W3043178839C185592680 @default.
- W3043178839 hasConceptScore W3043178839C2776789170 @default.
- W3043178839 hasConceptScore W3043178839C2778004101 @default.
- W3043178839 hasConceptScore W3043178839C2778816929 @default.
- W3043178839 hasConceptScore W3043178839C2779059548 @default.
- W3043178839 hasConceptScore W3043178839C2779101902 @default.
- W3043178839 hasConceptScore W3043178839C2779858419 @default.
- W3043178839 hasConceptScore W3043178839C2781401929 @default.
- W3043178839 hasConceptScore W3043178839C31896038 @default.
- W3043178839 hasConceptScore W3043178839C55493867 @default.
- W3043178839 hasConceptScore W3043178839C556039675 @default.
- W3043178839 hasConceptScore W3043178839C71924100 @default.
- W3043178839 hasConceptScore W3043178839C98274493 @default.
- W3043178839 hasIssue "3" @default.
- W3043178839 hasLocation W30431788391 @default.
- W3043178839 hasOpenAccess W3043178839 @default.
- W3043178839 hasPrimaryLocation W30431788391 @default.
- W3043178839 hasRelatedWork W1925726297 @default.
- W3043178839 hasRelatedWork W1985828711 @default.
- W3043178839 hasRelatedWork W1988302458 @default.
- W3043178839 hasRelatedWork W1991198753 @default.
- W3043178839 hasRelatedWork W2095642826 @default.
- W3043178839 hasRelatedWork W2164454997 @default.
- W3043178839 hasRelatedWork W2177263994 @default.
- W3043178839 hasRelatedWork W2320960851 @default.
- W3043178839 hasRelatedWork W2348030390 @default.
- W3043178839 hasRelatedWork W2766214534 @default.
- W3043178839 hasRelatedWork W2895218402 @default.
- W3043178839 hasRelatedWork W2954759433 @default.
- W3043178839 hasRelatedWork W2957904421 @default.
- W3043178839 hasRelatedWork W2980731393 @default.
- W3043178839 hasRelatedWork W2986325516 @default.
- W3043178839 hasRelatedWork W3014765992 @default.
- W3043178839 hasRelatedWork W3048483488 @default.
- W3043178839 hasRelatedWork W3183874449 @default.
- W3043178839 hasRelatedWork W3184848972 @default.