Matches in SemOpenAlex for { <https://semopenalex.org/work/W3043192984> ?p ?o ?g. }
- W3043192984 endingPage "11" @default.
- W3043192984 startingPage "1" @default.
- W3043192984 abstract "Boron neutron capture therapy (BNCT) is tumor-selective particle radiation therapy that depends on the nuclear capture and fission reactions. These reactions occur when a non-radioactive boron isotope (10B) is irradiated with low-energy thermal neutrons to yield high linear energy transfer α-particles and lithium-7 nuclei within a limited path length, i.e., an almost one-cell diameter. The 10B-containing cells can then be selectively destroyed by these potent particles. BNCT has been applied in the field of malignant brain tumors for newly diagnosed and recurrent malignant gliomas (chiefly glioblastomas). These clinical applications of BNCT have been performed with reactor-based neutron sources over the past decades. We also applied reactor-based BNCT for 58 newly diagnosed glioblastomas and 68 recurrent malignant gliomas including 52 glioblastomas. In this review article, we summarize the clinical results from the literature concerning BNCT for these high-grade gliomas (including our research). We also applied reactor-based BNCT for 46 cases of recurrent and refractory high-grade meningiomas, and some of the results will be presented herein. In Japan, neutron sources have been shifted from reactors to accelerators. Phase 1 and 2 clinical trials have been performed for recurrent malignant gliomas using accelerator-based neutron sources, and now fortunately, a cyclotron-based neutron generator has been approved as a medical device by Japanese regulatory authority, as the world’s first accelerator-based BNCT system for medical use. We also discuss the future prospects of accelerator-based BNCT in hospitals as therapy for malignant brain tumors." @default.
- W3043192984 created "2020-07-23" @default.
- W3043192984 creator A5008733751 @default.
- W3043192984 creator A5051374987 @default.
- W3043192984 creator A5069059367 @default.
- W3043192984 creator A5089261199 @default.
- W3043192984 date "2020-07-16" @default.
- W3043192984 modified "2023-10-17" @default.
- W3043192984 title "Boron neutron capture therapy for malignant brain tumors" @default.
- W3043192984 cites W1557563654 @default.
- W3043192984 cites W1563433962 @default.
- W3043192984 cites W1965838160 @default.
- W3043192984 cites W1968022202 @default.
- W3043192984 cites W1970094203 @default.
- W3043192984 cites W1970216633 @default.
- W3043192984 cites W1975125562 @default.
- W3043192984 cites W1981205626 @default.
- W3043192984 cites W1983343441 @default.
- W3043192984 cites W1986752336 @default.
- W3043192984 cites W1989030471 @default.
- W3043192984 cites W1992076192 @default.
- W3043192984 cites W1992893200 @default.
- W3043192984 cites W1993912959 @default.
- W3043192984 cites W1994545680 @default.
- W3043192984 cites W1995312162 @default.
- W3043192984 cites W2002879660 @default.
- W3043192984 cites W2009520901 @default.
- W3043192984 cites W2010897296 @default.
- W3043192984 cites W2012989539 @default.
- W3043192984 cites W2013053295 @default.
- W3043192984 cites W2014138113 @default.
- W3043192984 cites W2023940095 @default.
- W3043192984 cites W2025207041 @default.
- W3043192984 cites W2031033113 @default.
- W3043192984 cites W2031600211 @default.
- W3043192984 cites W2033996844 @default.
- W3043192984 cites W2036114535 @default.
- W3043192984 cites W2037317509 @default.
- W3043192984 cites W2040006132 @default.
- W3043192984 cites W2044943937 @default.
- W3043192984 cites W2044964496 @default.
- W3043192984 cites W2045344010 @default.
- W3043192984 cites W2055341486 @default.
- W3043192984 cites W2055800013 @default.
- W3043192984 cites W2063055054 @default.
- W3043192984 cites W2063922604 @default.
- W3043192984 cites W2067043175 @default.
- W3043192984 cites W2069505107 @default.
- W3043192984 cites W2085535471 @default.
- W3043192984 cites W2088472732 @default.
- W3043192984 cites W2090046394 @default.
- W3043192984 cites W2092903037 @default.
- W3043192984 cites W2096269794 @default.
- W3043192984 cites W2096287682 @default.
- W3043192984 cites W2098100032 @default.
- W3043192984 cites W2100673960 @default.
- W3043192984 cites W2101339203 @default.
- W3043192984 cites W2102691127 @default.
- W3043192984 cites W2103433412 @default.
- W3043192984 cites W2103875971 @default.
- W3043192984 cites W2106670937 @default.
- W3043192984 cites W2108737219 @default.
- W3043192984 cites W2124671697 @default.
- W3043192984 cites W2124736921 @default.
- W3043192984 cites W2126460855 @default.
- W3043192984 cites W2136963436 @default.
- W3043192984 cites W2138285516 @default.
- W3043192984 cites W2141170483 @default.
- W3043192984 cites W2145030327 @default.
- W3043192984 cites W2147484875 @default.
- W3043192984 cites W2153857176 @default.
- W3043192984 cites W2156330848 @default.
- W3043192984 cites W2158407480 @default.
- W3043192984 cites W2164933324 @default.
- W3043192984 cites W2166255908 @default.
- W3043192984 cites W2167534214 @default.
- W3043192984 cites W2306657189 @default.
- W3043192984 cites W2467294463 @default.
- W3043192984 cites W2900970801 @default.
- W3043192984 cites W2946581680 @default.
- W3043192984 cites W2963262695 @default.
- W3043192984 cites W3002536976 @default.
- W3043192984 cites W4229550919 @default.
- W3043192984 doi "https://doi.org/10.1007/s11060-020-03586-6" @default.
- W3043192984 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32676954" @default.
- W3043192984 hasPublicationYear "2020" @default.
- W3043192984 type Work @default.
- W3043192984 sameAs 3043192984 @default.
- W3043192984 citedByCount "41" @default.
- W3043192984 countsByYear W30431929842021 @default.
- W3043192984 countsByYear W30431929842022 @default.
- W3043192984 countsByYear W30431929842023 @default.
- W3043192984 crossrefType "journal-article" @default.
- W3043192984 hasAuthorship W3043192984A5008733751 @default.
- W3043192984 hasAuthorship W3043192984A5051374987 @default.
- W3043192984 hasAuthorship W3043192984A5069059367 @default.
- W3043192984 hasAuthorship W3043192984A5089261199 @default.
- W3043192984 hasBestOaLocation W30431929842 @default.