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- W3043242019 abstract "Abstract RNA interference is an essential and powerful tool for targeting and verifying specific gene functions. Conditional control of small interfering RNA (siRNA) activity, especially using light activation, is a potential method for regulating target gene expression and functions. In this study, a series of photolabile siRNAs with amantadine modification have been rationally designed and developed through host–guest interactions between amantadine and β‐cyclodextrin derivatives to enhance the blocking effect of siRNA binding and/or RNA‐induced silencing complex processing. These caged siRNAs with amantadine modification at the 5′ end of antisense‐strand RNA were efficiently inactivated through the host–guest interactions between amantadine and β‐cyclodextrin. Photomodulation of the gene silencing activity of these amantadine‐modified caged siRNAs targeting both exogenous and endogenous genes was successfully achieved, which indicates that host–guest interactions could be a new strategy for developing new caged siRNAs for gene photoregulation with low leaking activity." @default.
- W3043242019 created "2020-07-23" @default.
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- W3043242019 date "2020-09-30" @default.
- W3043242019 modified "2023-10-12" @default.
- W3043242019 title "Photoregulation of Gene Expression with Amantadine‐Modified Caged siRNAs through Host–Guest Interactions" @default.
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- W3043242019 doi "https://doi.org/10.1002/chem.202003084" @default.
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