FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3043272814> ?p ?o ?g. }

• W3043272814 endingPage "571" @default.
• W3043272814 startingPage "571" @default.
• W3043272814 abstract "Brucella abortus is a pathogenic bacterium able to proliferate inside host cells. During the first steps of its trafficking, it is able to block the progression of its cell cycle, remaining at the G1 stage for several hours, before it reaches its replication niche. We hypothesized that starvation mediated by guanosine tetra- or penta-phosphate, (p)ppGpp, could be involved in the cell cycle arrest. Rsh is the (p)ppGpp synthetase/hydrolase. A B. abortus ∆rsh mutant is unable to grow in minimal medium, it is unable to survive in stationary phase in rich medium and it is unable to proliferate inside RAW 264.7 macrophages. A strain producing the heterologous constitutive (p)ppGpp hydrolase Mesh1b is also unable to proliferate inside these macrophages. Altogether, these data suggest that (p)ppGpp is necessary to allow B. abortus to adapt to its intracellular growth conditions. The deletion of dksA, proposed to mediate a part of the effect of (p)ppGpp on transcription, does not affect B. abortus growth in culture or inside macrophages. Expression of a gene coding for a constitutively active (p)ppGpp synthetase slows down growth in rich medium and inside macrophages. Using an mCherry–ParB fusion able to bind to the replication origin of the main chromosome of B. abortus, we observed that expression of the constitutive (p)ppGpp synthetase gene generates an accumulation of bacteria at the G1 phase. We thus propose that (p)ppGpp accumulation could be one of the factors contributing to the G1 arrest observed for B. abortus in RAW 264.7 macrophages." @default.
• W3043272814 created "2020-07-23" @default.
• W3043272814 creator A5007301426 @default.
• W3043272814 creator A5015172393 @default.
• W3043272814 creator A5018167008 @default.
• W3043272814 date "2020-07-14" @default.
• W3043272814 modified "2023-09-25" @default.
• W3043272814 title "Intracellular Growth and Cell Cycle Progression are Dependent on (p)ppGpp Synthetase/Hydrolase in Brucella abortus" @default.
• W3043272814 cites W1969222627 @default.
• W3043272814 cites W1976680916 @default.
• W3043272814 cites W1984800057 @default.
• W3043272814 cites W1988310011 @default.
• W3043272814 cites W2008186432 @default.
• W3043272814 cites W2014345020 @default.
• W3043272814 cites W2026397514 @default.
• W3043272814 cites W2035385414 @default.
• W3043272814 cites W2036735937 @default.
• W3043272814 cites W2050896016 @default.
• W3043272814 cites W2056133106 @default.
• W3043272814 cites W2073018660 @default.
• W3043272814 cites W2077116102 @default.
• W3043272814 cites W2089184777 @default.
• W3043272814 cites W2097183117 @default.
• W3043272814 cites W2098259424 @default.
• W3043272814 cites W2108712424 @default.
• W3043272814 cites W2110393270 @default.
• W3043272814 cites W2114648588 @default.
• W3043272814 cites W2127845652 @default.
• W3043272814 cites W2128954452 @default.
• W3043272814 cites W2146120613 @default.
• W3043272814 cites W2147075264 @default.
• W3043272814 cites W2154657387 @default.
• W3043272814 cites W2160947128 @default.
• W3043272814 cites W2162361135 @default.
• W3043272814 cites W2345005054 @default.
• W3043272814 cites W2400534995 @default.
• W3043272814 cites W2460832886 @default.
• W3043272814 cites W2806600957 @default.
• W3043272814 cites W2925280602 @default.
• W3043272814 cites W2949607783 @default.
• W3043272814 cites W2981390837 @default.
• W3043272814 doi "https://doi.org/10.3390/pathogens9070571" @default.
• W3043272814 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7400157" @default.
• W3043272814 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32674466" @default.
• W3043272814 hasPublicationYear "2020" @default.
• W3043272814 type Work @default.
• W3043272814 sameAs 3043272814 @default.
• W3043272814 citedByCount "5" @default.
• W3043272814 countsByYear W30432728142021 @default.
• W3043272814 countsByYear W30432728142022 @default.
• W3043272814 countsByYear W30432728142023 @default.
• W3043272814 crossrefType "journal-article" @default.
• W3043272814 hasAuthorship W3043272814A5007301426 @default.
• W3043272814 hasAuthorship W3043272814A5015172393 @default.
• W3043272814 hasAuthorship W3043272814A5018167008 @default.
• W3043272814 hasBestOaLocation W30432728141 @default.
• W3043272814 hasConcept C104317684 @default.
• W3043272814 hasConcept C138885662 @default.
• W3043272814 hasConcept C143065580 @default.
• W3043272814 hasConcept C179926584 @default.
• W3043272814 hasConcept C26628138 @default.
• W3043272814 hasConcept C41895202 @default.
• W3043272814 hasConcept C55493867 @default.
• W3043272814 hasConcept C62112901 @default.
• W3043272814 hasConcept C79879829 @default.
• W3043272814 hasConcept C86803240 @default.
• W3043272814 hasConcept C89423630 @default.
• W3043272814 hasConcept C95444343 @default.
• W3043272814 hasConceptScore W3043272814C104317684 @default.
• W3043272814 hasConceptScore W3043272814C138885662 @default.
• W3043272814 hasConceptScore W3043272814C143065580 @default.
• W3043272814 hasConceptScore W3043272814C179926584 @default.
• W3043272814 hasConceptScore W3043272814C26628138 @default.
• W3043272814 hasConceptScore W3043272814C41895202 @default.
• W3043272814 hasConceptScore W3043272814C55493867 @default.
• W3043272814 hasConceptScore W3043272814C62112901 @default.
• W3043272814 hasConceptScore W3043272814C79879829 @default.
• W3043272814 hasConceptScore W3043272814C86803240 @default.
• W3043272814 hasConceptScore W3043272814C89423630 @default.
• W3043272814 hasConceptScore W3043272814C95444343 @default.
• W3043272814 hasIssue "7" @default.
• W3043272814 hasLocation W30432728141 @default.
• W3043272814 hasLocation W30432728142 @default.
• W3043272814 hasLocation W30432728143 @default.
• W3043272814 hasLocation W30432728144 @default.
• W3043272814 hasOpenAccess W3043272814 @default.
• W3043272814 hasPrimaryLocation W30432728141 @default.
• W3043272814 hasRelatedWork W1969676666 @default.
• W3043272814 hasRelatedWork W2001677368 @default.
• W3043272814 hasRelatedWork W2009966535 @default.
• W3043272814 hasRelatedWork W2019988726 @default.
• W3043272814 hasRelatedWork W2088063203 @default.
• W3043272814 hasRelatedWork W2097265502 @default.
• W3043272814 hasRelatedWork W2120393042 @default.
• W3043272814 hasRelatedWork W2171277769 @default.
• W3043272814 hasRelatedWork W2423871774 @default.
• W3043272814 hasRelatedWork W2913645037 @default.
• W3043272814 hasVolume "9" @default.

• next