FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3043284929> ?p ?o ?g. }

• W3043284929 endingPage "11" @default.
• W3043284929 startingPage "1" @default.
• W3043284929 abstract "Purposes . Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in the world. Recent researches have demonstrated that m6A methylation regulators play a key role in various cancers, such as gastric cancer and colon adenocarcinoma. Several m6A methylation regulators are reported to predict the prognosis of HCC. Therefore, there is a need to further identify the predictive value of m6A methylation regulators in HCC. Methods . We utilized The Cancer Genome Atlas (TCGA) database to obtain the gene expression profile of m6A RNA methylation regulators and clinical information for patients with HCC. Besides, we identified two clusters of HCC with various clinical factors by consensus clustering analysis. Then the least absolute shrinkage and selection operator (LASSO) and the Cox regression analysis were applied to construct a prognostic signature. Results . Except for ZC3H13 and METTL14, a majority of the thirteen m6A RNA methylation regulators were significantly overexpressed in HCC specimens. HCC patients were classified into two groups (cluster 1 and cluster 2). The cluster 1 was with a significantly worse prognosis than cluster 2, and most of the 13 known m6A RNA methylation regulators were upregulated in cluster 1. Besides, we developed a prognostic signature consisting of YTHDF2, YTHDF1, METTL3, KIAA1429, and ZC3H13, which could successfully differentiate high-risk patients. More importantly, univariate and multivariate Cox regression analysis indicated that the signature-based risk score was an independent prognostic factor for patients with HCC. Conclusions . Our study showed these five m6A RNA methylation regulators can be used as practical and reliable prognostic tools of HCC, which might have potential value for therapeutic strategies." @default.
• W3043284929 created "2020-07-23" @default.
• W3043284929 creator A5001693827 @default.
• W3043284929 creator A5014654873 @default.
• W3043284929 creator A5051480539 @default.
• W3043284929 creator A5062971939 @default.
• W3043284929 creator A5071505540 @default.
• W3043284929 date "2020-07-15" @default.
• W3043284929 modified "2023-10-13" @default.
• W3043284929 title "Prognostic Value of an m6A RNA Methylation Regulator-Based Signature in Patients with Hepatocellular Carcinoma" @default.
• W3043284929 cites W1947267113 @default.
• W3043284929 cites W2027053992 @default.
• W3043284929 cites W2115462905 @default.
• W3043284929 cites W2146512944 @default.
• W3043284929 cites W2157825442 @default.
• W3043284929 cites W2315027248 @default.
• W3043284929 cites W2341442578 @default.
• W3043284929 cites W2346857231 @default.
• W3043284929 cites W2538543247 @default.
• W3043284929 cites W2563912688 @default.
• W3043284929 cites W2591717879 @default.
• W3043284929 cites W2597872842 @default.
• W3043284929 cites W2768772716 @default.
• W3043284929 cites W2769528818 @default.
• W3043284929 cites W2770747479 @default.
• W3043284929 cites W2771543893 @default.
• W3043284929 cites W2784196060 @default.
• W3043284929 cites W2787358630 @default.
• W3043284929 cites W2803154276 @default.
• W3043284929 cites W2837459302 @default.
• W3043284929 cites W2885250628 @default.
• W3043284929 cites W2886253007 @default.
• W3043284929 cites W2888375528 @default.
• W3043284929 cites W2889646458 @default.
• W3043284929 cites W2890215329 @default.
• W3043284929 cites W2897789847 @default.
• W3043284929 cites W2916807836 @default.
• W3043284929 cites W2943695742 @default.
• W3043284929 cites W2947674709 @default.
• W3043284929 cites W2948955366 @default.
• W3043284929 cites W2951746943 @default.
• W3043284929 cites W2969232224 @default.
• W3043284929 cites W2969802526 @default.
• W3043284929 cites W2977905919 @default.
• W3043284929 cites W2996655167 @default.
• W3043284929 cites W4362203923 @default.
• W3043284929 doi "https://doi.org/10.1155/2020/2053902" @default.
• W3043284929 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7378627" @default.
• W3043284929 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32733931" @default.
• W3043284929 hasPublicationYear "2020" @default.
• W3043284929 type Work @default.
• W3043284929 sameAs 3043284929 @default.
• W3043284929 citedByCount "22" @default.
• W3043284929 countsByYear W30432849292020 @default.
• W3043284929 countsByYear W30432849292021 @default.
• W3043284929 countsByYear W30432849292022 @default.
• W3043284929 countsByYear W30432849292023 @default.
• W3043284929 crossrefType "journal-article" @default.
• W3043284929 hasAuthorship W3043284929A5001693827 @default.
• W3043284929 hasAuthorship W3043284929A5014654873 @default.
• W3043284929 hasAuthorship W3043284929A5051480539 @default.
• W3043284929 hasAuthorship W3043284929A5062971939 @default.
• W3043284929 hasAuthorship W3043284929A5071505540 @default.
• W3043284929 hasBestOaLocation W30432849291 @default.
• W3043284929 hasConcept C104317684 @default.
• W3043284929 hasConcept C126322002 @default.
• W3043284929 hasConcept C143998085 @default.
• W3043284929 hasConcept C150194340 @default.
• W3043284929 hasConcept C190727270 @default.
• W3043284929 hasConcept C2778019345 @default.
• W3043284929 hasConcept C2779733811 @default.
• W3043284929 hasConcept C2909856833 @default.
• W3043284929 hasConcept C33288867 @default.
• W3043284929 hasConcept C502942594 @default.
• W3043284929 hasConcept C50382708 @default.
• W3043284929 hasConcept C54355233 @default.
• W3043284929 hasConcept C71924100 @default.
• W3043284929 hasConcept C86803240 @default.
• W3043284929 hasConcept C91965660 @default.
• W3043284929 hasConceptScore W3043284929C104317684 @default.
• W3043284929 hasConceptScore W3043284929C126322002 @default.
• W3043284929 hasConceptScore W3043284929C143998085 @default.
• W3043284929 hasConceptScore W3043284929C150194340 @default.
• W3043284929 hasConceptScore W3043284929C190727270 @default.
• W3043284929 hasConceptScore W3043284929C2778019345 @default.
• W3043284929 hasConceptScore W3043284929C2779733811 @default.
• W3043284929 hasConceptScore W3043284929C2909856833 @default.
• W3043284929 hasConceptScore W3043284929C33288867 @default.
• W3043284929 hasConceptScore W3043284929C502942594 @default.
• W3043284929 hasConceptScore W3043284929C50382708 @default.
• W3043284929 hasConceptScore W3043284929C54355233 @default.
• W3043284929 hasConceptScore W3043284929C71924100 @default.
• W3043284929 hasConceptScore W3043284929C86803240 @default.
• W3043284929 hasConceptScore W3043284929C91965660 @default.
• W3043284929 hasLocation W30432849291 @default.
• W3043284929 hasLocation W30432849292 @default.
• W3043284929 hasLocation W30432849293 @default.
• W3043284929 hasOpenAccess W3043284929 @default.

• next