Matches in SemOpenAlex for { <https://semopenalex.org/work/W3043292029> ?p ?o ?g. }
- W3043292029 abstract "Introduction: Cardiac glycosides are widely used in critical cardiac diseases despite their unexplained mechanisms on cardio-respiratory system and other autonomic complications within both intra-uterine and post-natal life. The aim of this study is to investigate if digitalis overdose could cause a result in such complications by a destructive effect on blood-brain barrier (BBB). Methods: Twenty-five male Sprague Dawley rats weighing 300–350 g were divided into the following groups: control (n=5), sham (isotonic) (n=5), therapeutic dose (n=5), arrhythmogenic dose (n=5), and lethal dose (n=5). The animals were euthanized and their brains were extracted. The brains were histopathologically and immunohistochemically examined to evaluate BBB morphology in the superior temporal cortex. Results: One animal died because of experimental procedures on the first day. Macroscopic examination of brains revealed brain edema, subarachnoid hemorrhage (SAH), and narrowed cisterns in toxic doses of digitalis-treated animals. Brain histopathological examination of these groups revealed bloody subarachnoid and cisternal spaces, cortical arteriolar vasospasm, neurodegeneration, and even peri-arteriolar neuroglial component fragmentation; these changes induced BBB destruction in the high-dose digitalis-treated animals. Conclusion: Digitalis should not be used with overdoses if the cardio-respiratory arrhythmia is unexpectedly appearing in low doses against the possibility of defected or disrupted BBB." @default.
- W3043292029 created "2020-07-23" @default.
- W3043292029 creator A5012909402 @default.
- W3043292029 creator A5014700239 @default.
- W3043292029 creator A5051538716 @default.
- W3043292029 creator A5053987652 @default.
- W3043292029 creator A5073101952 @default.
- W3043292029 creator A5079370709 @default.
- W3043292029 date "2020-07-12" @default.
- W3043292029 modified "2023-09-24" @default.
- W3043292029 title "Destructive effect of digitalis overdose on blood-brain barrier in rats; an experimental study" @default.
- W3043292029 cites W1516798486 @default.
- W3043292029 cites W154445719 @default.
- W3043292029 cites W1972857089 @default.
- W3043292029 cites W1977103029 @default.
- W3043292029 cites W1978202221 @default.
- W3043292029 cites W1980098382 @default.
- W3043292029 cites W1989816819 @default.
- W3043292029 cites W2000649353 @default.
- W3043292029 cites W2009841576 @default.
- W3043292029 cites W2016471165 @default.
- W3043292029 cites W2021310458 @default.
- W3043292029 cites W2026392511 @default.
- W3043292029 cites W2028989504 @default.
- W3043292029 cites W2036155711 @default.
- W3043292029 cites W2036453518 @default.
- W3043292029 cites W2040196494 @default.
- W3043292029 cites W2042838133 @default.
- W3043292029 cites W2044134608 @default.
- W3043292029 cites W2045330490 @default.
- W3043292029 cites W2046864079 @default.
- W3043292029 cites W2048277843 @default.
- W3043292029 cites W2050997734 @default.
- W3043292029 cites W2061579855 @default.
- W3043292029 cites W2063407739 @default.
- W3043292029 cites W2065058273 @default.
- W3043292029 cites W2066873235 @default.
- W3043292029 cites W2068028691 @default.
- W3043292029 cites W2069679261 @default.
- W3043292029 cites W2073748140 @default.
- W3043292029 cites W2078996708 @default.
- W3043292029 cites W2083691068 @default.
- W3043292029 cites W2090015700 @default.
- W3043292029 cites W2090481867 @default.
- W3043292029 cites W2092499991 @default.
- W3043292029 cites W2092970599 @default.
- W3043292029 cites W2094097135 @default.
- W3043292029 cites W2101610746 @default.
- W3043292029 cites W2110537012 @default.
- W3043292029 cites W2128511162 @default.
- W3043292029 cites W2131712800 @default.
- W3043292029 cites W2159088913 @default.
- W3043292029 cites W2176044393 @default.
- W3043292029 cites W2222603156 @default.
- W3043292029 cites W2410348357 @default.
- W3043292029 cites W2411597255 @default.
- W3043292029 cites W2413836122 @default.
- W3043292029 cites W2540248011 @default.
- W3043292029 cites W54362190 @default.
- W3043292029 cites W68762750 @default.
- W3043292029 cites W2063186248 @default.
- W3043292029 doi "https://doi.org/10.34172/jrcm.2020.025" @default.
- W3043292029 hasPublicationYear "2020" @default.
- W3043292029 type Work @default.
- W3043292029 sameAs 3043292029 @default.
- W3043292029 citedByCount "0" @default.
- W3043292029 crossrefType "journal-article" @default.
- W3043292029 hasAuthorship W3043292029A5012909402 @default.
- W3043292029 hasAuthorship W3043292029A5014700239 @default.
- W3043292029 hasAuthorship W3043292029A5051538716 @default.
- W3043292029 hasAuthorship W3043292029A5053987652 @default.
- W3043292029 hasAuthorship W3043292029A5073101952 @default.
- W3043292029 hasAuthorship W3043292029A5079370709 @default.
- W3043292029 hasBestOaLocation W30432920291 @default.
- W3043292029 hasConcept C126322002 @default.
- W3043292029 hasConcept C142724271 @default.
- W3043292029 hasConcept C2776445394 @default.
- W3043292029 hasConcept C2777736543 @default.
- W3043292029 hasConcept C2778198053 @default.
- W3043292029 hasConcept C2778402981 @default.
- W3043292029 hasConcept C2778506911 @default.
- W3043292029 hasConcept C42219234 @default.
- W3043292029 hasConcept C529278444 @default.
- W3043292029 hasConcept C71924100 @default.
- W3043292029 hasConceptScore W3043292029C126322002 @default.
- W3043292029 hasConceptScore W3043292029C142724271 @default.
- W3043292029 hasConceptScore W3043292029C2776445394 @default.
- W3043292029 hasConceptScore W3043292029C2777736543 @default.
- W3043292029 hasConceptScore W3043292029C2778198053 @default.
- W3043292029 hasConceptScore W3043292029C2778402981 @default.
- W3043292029 hasConceptScore W3043292029C2778506911 @default.
- W3043292029 hasConceptScore W3043292029C42219234 @default.
- W3043292029 hasConceptScore W3043292029C529278444 @default.
- W3043292029 hasConceptScore W3043292029C71924100 @default.
- W3043292029 hasLocation W30432920291 @default.
- W3043292029 hasOpenAccess W3043292029 @default.
- W3043292029 hasPrimaryLocation W30432920291 @default.
- W3043292029 hasRelatedWork W10639093 @default.
- W3043292029 hasRelatedWork W1126642 @default.
- W3043292029 hasRelatedWork W13004958 @default.