FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3043302681> ?p ?o ?g. }

• W3043302681 endingPage "33" @default.
• W3043302681 startingPage "27" @default.
• W3043302681 abstract "Abstract Background and Objective The complement system is engaged in inflammatory reactions both in the periodontal pockets and in the periodontium itself, where it can mediate tissue destruction. The aim of this study was, first, to compare salivary levels of the total complement system protein C3 and its split product, fluid‐phase C3c in patients with periodontitis and periodontally healthy controls. Next, to determine if C3 and C3c levels had biomarker potential in diagnosing and monitoring periodontitis and its treatment. We hypothesized that salivary levels of total C3 and the split product C3c associated with the severity of periodontitis and reflected decreased inflammatory activity after periodontal treatment. Methods At baseline, stimulated saliva samples were collected from patients with periodontitis (n = 18) and periodontally healthy controls (n = 15). Subsequently, non‐surgical periodontal treatment was performed in the patients, and saliva sampling from patients was repeated two‐, six‐, and twelve weeks post‐treatment (NCT02913248 at clinicaltrials.gov). The patients were grouped as good and poor responders to treatment according to the achieved reduction in bleeding on probing (BOP). Salivary levels of C3 and C3c were quantified using sandwich ELISA. Results Patients with periodontitis had higher baseline levels of both total C3 and the split product C3c in saliva than did periodontally healthy controls ( P < .0001). Receiver operating curve (ROC) analyses discriminated patients with periodontitis from controls based on both C3 (AUC (area under curve) = 0.91, P < .001) and C3c levels (AUC = 0.84, P < .001) in saliva. Periodontal treatment improved all clinical parameters ( P < .01). Good responders (n = 10) had lower baseline levels of C3c than poor responders (n = 8), ( P < .05), and baseline levels of C3c discriminated between good and poor responders (AUC = 0.80, P < .05). Conclusion In conclusion, patients with periodontitis had higher salivary levels of C3c, and the C3c levels were predictive of reductions in BOP, that is, the poor responders. This suggests that salivary C3c levels possess potential to serve as a biomarker predicting the clinical response to non‐surgical periodontal treatment." @default.
• W3043302681 created "2020-07-23" @default.
• W3043302681 creator A5039669329 @default.
• W3043302681 creator A5047653317 @default.
• W3043302681 creator A5048861529 @default.
• W3043302681 creator A5058805428 @default.
• W3043302681 creator A5060399289 @default.
• W3043302681 creator A5085587195 @default.
• W3043302681 creator A5087725573 @default.
• W3043302681 date "2020-07-18" @default.
• W3043302681 modified "2023-10-03" @default.
• W3043302681 title "Complement split product C3c in saliva as biomarker for periodontitis and response to periodontal treatment" @default.
• W3043302681 cites W1884635290 @default.
• W3043302681 cites W1962796946 @default.
• W3043302681 cites W1969787878 @default.
• W3043302681 cites W1980548993 @default.
• W3043302681 cites W2007291667 @default.
• W3043302681 cites W2008601904 @default.
• W3043302681 cites W2018165775 @default.
• W3043302681 cites W2043248182 @default.
• W3043302681 cites W2056938675 @default.
• W3043302681 cites W2067119953 @default.
• W3043302681 cites W2089321040 @default.
• W3043302681 cites W2090443712 @default.
• W3043302681 cites W2091933198 @default.
• W3043302681 cites W2109704203 @default.
• W3043302681 cites W2123649398 @default.
• W3043302681 cites W2135800998 @default.
• W3043302681 cites W2147854986 @default.
• W3043302681 cites W2167003442 @default.
• W3043302681 cites W2167362969 @default.
• W3043302681 cites W2167821466 @default.
• W3043302681 cites W2230061649 @default.
• W3043302681 cites W2238429315 @default.
• W3043302681 cites W2290243602 @default.
• W3043302681 cites W2584323583 @default.
• W3043302681 cites W2598638169 @default.
• W3043302681 cites W2727063394 @default.
• W3043302681 cites W2741223751 @default.
• W3043302681 cites W2791377599 @default.
• W3043302681 cites W2801582312 @default.
• W3043302681 cites W2809948294 @default.
• W3043302681 cites W2864036222 @default.
• W3043302681 cites W2885241421 @default.
• W3043302681 cites W2992085522 @default.
• W3043302681 doi "https://doi.org/10.1111/jre.12788" @default.
• W3043302681 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7891408" @default.
• W3043302681 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32681659" @default.
• W3043302681 hasPublicationYear "2020" @default.
• W3043302681 type Work @default.
• W3043302681 sameAs 3043302681 @default.
• W3043302681 citedByCount "20" @default.
• W3043302681 countsByYear W30433026812020 @default.
• W3043302681 countsByYear W30433026812021 @default.
• W3043302681 countsByYear W30433026812022 @default.
• W3043302681 countsByYear W30433026812023 @default.
• W3043302681 crossrefType "journal-article" @default.
• W3043302681 hasAuthorship W3043302681A5039669329 @default.
• W3043302681 hasAuthorship W3043302681A5047653317 @default.
• W3043302681 hasAuthorship W3043302681A5048861529 @default.
• W3043302681 hasAuthorship W3043302681A5058805428 @default.
• W3043302681 hasAuthorship W3043302681A5060399289 @default.
• W3043302681 hasAuthorship W3043302681A5085587195 @default.
• W3043302681 hasAuthorship W3043302681A5087725573 @default.
• W3043302681 hasBestOaLocation W30433026811 @default.
• W3043302681 hasConcept C126322002 @default.
• W3043302681 hasConcept C185592680 @default.
• W3043302681 hasConcept C199343813 @default.
• W3043302681 hasConcept C2777968807 @default.
• W3043302681 hasConcept C2778380114 @default.
• W3043302681 hasConcept C2778883934 @default.
• W3043302681 hasConcept C2780385504 @default.
• W3043302681 hasConcept C2781197716 @default.
• W3043302681 hasConcept C504460877 @default.
• W3043302681 hasConcept C55493867 @default.
• W3043302681 hasConcept C58471807 @default.
• W3043302681 hasConcept C71924100 @default.
• W3043302681 hasConcept C76318530 @default.
• W3043302681 hasConcept C90924648 @default.
• W3043302681 hasConceptScore W3043302681C126322002 @default.
• W3043302681 hasConceptScore W3043302681C185592680 @default.
• W3043302681 hasConceptScore W3043302681C199343813 @default.
• W3043302681 hasConceptScore W3043302681C2777968807 @default.
• W3043302681 hasConceptScore W3043302681C2778380114 @default.
• W3043302681 hasConceptScore W3043302681C2778883934 @default.
• W3043302681 hasConceptScore W3043302681C2780385504 @default.
• W3043302681 hasConceptScore W3043302681C2781197716 @default.
• W3043302681 hasConceptScore W3043302681C504460877 @default.
• W3043302681 hasConceptScore W3043302681C55493867 @default.
• W3043302681 hasConceptScore W3043302681C58471807 @default.
• W3043302681 hasConceptScore W3043302681C71924100 @default.
• W3043302681 hasConceptScore W3043302681C76318530 @default.
• W3043302681 hasConceptScore W3043302681C90924648 @default.
• W3043302681 hasIssue "1" @default.
• W3043302681 hasLocation W30433026811 @default.
• W3043302681 hasLocation W30433026812 @default.
• W3043302681 hasLocation W30433026813 @default.
• W3043302681 hasOpenAccess W3043302681 @default.

• next