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- W3043303918 endingPage "114" @default.
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- W3043303918 abstract "Understanding the molecular and cellular mechanisms involved during the onset of epilepsy is crucial for elucidating the overall mechanism of epileptogenesis and therapeutic strategies. Previous studies, using a pentylenetetrazole (PTZ)-induced kindling mouse model, showed that astrocyte activation and an increase in perineuronal nets (PNNs) and extracellular matrix (ECM) molecules occurred within the hippocampus. However, the mechanisms of initiation and suppression of these changes, remain unclear. Herein, we analyzed the attenuation of astrocyte activation caused by dizocilpine (MK-801) administration, as well as the anticonvulsant effect of α-pinene on seizures and production of ECM molecules. Our results showed that MK-801 significantly reduced kindling acquisition, while α-pinene treatment prevented an increase in seizures incidences. Both MK-801 and α-pinene administration attenuated astrocyte activation by PTZ and significantly attenuated the increase in ECM molecules. Our results indicate that astrocyte activation and an increase in ECM may contribute to epileptogenesis and suggest that MK-801 and α-pinene may prevent epileptic seizures by suppressing astrocyte activation and ECM molecule production." @default.
- W3043303918 created "2020-07-23" @default.
- W3043303918 creator A5009203536 @default.
- W3043303918 creator A5015145916 @default.
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- W3043303918 creator A5073695796 @default.
- W3043303918 creator A5079456672 @default.
- W3043303918 creator A5087217136 @default.
- W3043303918 date "2020-12-01" @default.
- W3043303918 modified "2023-09-30" @default.
- W3043303918 title "Alpha-pinene and dizocilpine (MK-801) attenuate kindling development and astrocytosis in an experimental mouse model of epilepsy" @default.
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