Matches in SemOpenAlex for { <https://semopenalex.org/work/W3043313641> ?p ?o ?g. }
- W3043313641 endingPage "26751" @default.
- W3043313641 startingPage "26742" @default.
- W3043313641 abstract "Inorganic nanoparticles (NPs)-mediated tumor theranostics have attracted widespread attention due to their unique physicochemical properties, such as optical, electrical, magnetic, and thermal properties. In the past decade, great advancements have been made in inorganic NPs-associated drug delivery, multimodal tumor imaging, and tumor therapy. However, the potential toxicity of inorganic NPs due to their low biodegradability, background signals interference and treatment side effects limit their clinical application. Therefore, developing biodegradable and intelligent NPs is beneficial to avoid excessive metal ions deposition, specific tumor imaging and treatment. In this review, we summarize the recent advances in tumor microenvironment (TME)-triggered biodegradation of inorganic NPs accompanied by imaging signal amplification and the released ions-mediated tumor therapy. First, the feature characteristics of the TME are introduced, including mild acidity, hypoxia, overexpressed reactive oxygen species (ROS), glutathione (GSH), and enzymes et al.; then, the biodegradation of NPs in a TME-induced activation of imaging signals, such as magnetic resonance (MR) imaging and fluorescence imaging is described; furthermore, tumor therapies through Fenton, Fenton-like reactions, and interference of biological effects in cells is presented. Finally, the challenges and outlook for improving the degradation efficiency, imaging, specificity and efficiency of tumor imaging and treatment are discussed." @default.
- W3043313641 created "2020-07-23" @default.
- W3043313641 creator A5029048408 @default.
- W3043313641 creator A5029899255 @default.
- W3043313641 creator A5040924028 @default.
- W3043313641 creator A5045246722 @default.
- W3043313641 creator A5080784459 @default.
- W3043313641 creator A5082958935 @default.
- W3043313641 date "2020-01-01" @default.
- W3043313641 modified "2023-10-14" @default.
- W3043313641 title "Tumor microenvironment triggered biodegradation of inorganic nanoparticles for enhanced tumor theranostics" @default.
- W3043313641 cites W1527954946 @default.
- W3043313641 cites W1809723326 @default.
- W3043313641 cites W1834322579 @default.
- W3043313641 cites W1846935465 @default.
- W3043313641 cites W1964452411 @default.
- W3043313641 cites W1968142217 @default.
- W3043313641 cites W1971871177 @default.
- W3043313641 cites W1972825083 @default.
- W3043313641 cites W1983217073 @default.
- W3043313641 cites W1997270358 @default.
- W3043313641 cites W2011810742 @default.
- W3043313641 cites W2030295309 @default.
- W3043313641 cites W2035440890 @default.
- W3043313641 cites W2044245267 @default.
- W3043313641 cites W2069518226 @default.
- W3043313641 cites W2082483448 @default.
- W3043313641 cites W2089101547 @default.
- W3043313641 cites W2112238783 @default.
- W3043313641 cites W2114135715 @default.
- W3043313641 cites W2118817262 @default.
- W3043313641 cites W2134659188 @default.
- W3043313641 cites W2190994911 @default.
- W3043313641 cites W2271789602 @default.
- W3043313641 cites W2299520011 @default.
- W3043313641 cites W2318469969 @default.
- W3043313641 cites W2339343159 @default.
- W3043313641 cites W2344679303 @default.
- W3043313641 cites W2376997792 @default.
- W3043313641 cites W2411745697 @default.
- W3043313641 cites W2419545902 @default.
- W3043313641 cites W2487348170 @default.
- W3043313641 cites W2489121689 @default.
- W3043313641 cites W2522213855 @default.
- W3043313641 cites W2534568875 @default.
- W3043313641 cites W2541436531 @default.
- W3043313641 cites W2546723392 @default.
- W3043313641 cites W2586637063 @default.
- W3043313641 cites W2621875781 @default.
- W3043313641 cites W2747423355 @default.
- W3043313641 cites W2765750234 @default.
- W3043313641 cites W2787553551 @default.
- W3043313641 cites W2793503277 @default.
- W3043313641 cites W2801124226 @default.
- W3043313641 cites W2808603491 @default.
- W3043313641 cites W2889279681 @default.
- W3043313641 cites W2903659409 @default.
- W3043313641 cites W2911833497 @default.
- W3043313641 cites W2917837889 @default.
- W3043313641 cites W2921884395 @default.
- W3043313641 cites W2925118852 @default.
- W3043313641 cites W2943443652 @default.
- W3043313641 cites W2947512353 @default.
- W3043313641 cites W2947759020 @default.
- W3043313641 cites W2954904043 @default.
- W3043313641 cites W2963932652 @default.
- W3043313641 cites W2969503538 @default.
- W3043313641 cites W2979501869 @default.
- W3043313641 cites W2982280565 @default.
- W3043313641 cites W2989616962 @default.
- W3043313641 cites W2993437195 @default.
- W3043313641 cites W3003428717 @default.
- W3043313641 cites W3008370485 @default.
- W3043313641 cites W3011462768 @default.
- W3043313641 cites W3012340820 @default.
- W3043313641 doi "https://doi.org/10.1039/d0ra04651e" @default.
- W3043313641 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35515788" @default.
- W3043313641 hasPublicationYear "2020" @default.
- W3043313641 type Work @default.
- W3043313641 sameAs 3043313641 @default.
- W3043313641 citedByCount "8" @default.
- W3043313641 countsByYear W30433136412021 @default.
- W3043313641 countsByYear W30433136412022 @default.
- W3043313641 countsByYear W30433136412023 @default.
- W3043313641 crossrefType "journal-article" @default.
- W3043313641 hasAuthorship W3043313641A5029048408 @default.
- W3043313641 hasAuthorship W3043313641A5029899255 @default.
- W3043313641 hasAuthorship W3043313641A5040924028 @default.
- W3043313641 hasAuthorship W3043313641A5045246722 @default.
- W3043313641 hasAuthorship W3043313641A5080784459 @default.
- W3043313641 hasAuthorship W3043313641A5082958935 @default.
- W3043313641 hasBestOaLocation W30433136411 @default.
- W3043313641 hasConcept C121332964 @default.
- W3043313641 hasConcept C126322002 @default.
- W3043313641 hasConcept C126838900 @default.
- W3043313641 hasConcept C143409427 @default.
- W3043313641 hasConcept C155672457 @default.
- W3043313641 hasConcept C157021035 @default.