FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3043343913> ?p ?o ?g. }

• W3043343913 endingPage "1373" @default.
• W3043343913 startingPage "1361" @default.
• W3043343913 abstract "Eukaryotic cells, when exposed to environmental or internal stress, activate the integrated stress response (ISR) to restore homeostasis and promote cell survival. Specific stress stimuli prompt dedicated stress kinases to phosphorylate eukaryotic initiation factor 2 (eIF2). Phosphorylated eIF2 (p-eIF2) in turn sequesters the eIF2-specific guanine exchange factor eIF2B to block eIF2 recycling, thereby halting translation initiation and reducing global protein synthesis. To circumvent stress-induced translational shutdown, viruses encode ISR antagonists. Those identified so far prevent or reverse eIF2 phosphorylation. We now describe two viral proteins—one from a coronavirus and the other from a picornavirus—that have independently acquired the ability to counteract the ISR at its very core by acting as a competitive inhibitor of p-eIF2–eIF2B interaction. This allows continued formation of the eIF2-GTP-Met-tRNAi ternary complex and unabated global translation at high p-eIF2 levels that would otherwise cause translational arrest. We conclude that eIF2 and p-eIF2 differ in their interaction with eIF2B to such effect that p-eIF2–eIF2B association can be selectively inhibited. The AcP10 protein—an active uridine kinase, encoded by the beluga whale coronavirus SW1—is an antagonist of the integrated stress response that acts downstream of phosphorylation of the translation initiation factor eIF2, irrespective of which eIF2 kinase is activated. AcP10 acts as a competitive inhibitor of the eIF2[P]–eIF2B interaction by binding to eIF2B. A protein with a similar function is also encoded by Aichivirus, a picornavirus." @default.
• W3043343913 created "2020-07-23" @default.
• W3043343913 creator A5001030335 @default.
• W3043343913 creator A5015172766 @default.
• W3043343913 creator A5019631651 @default.
• W3043343913 creator A5020538230 @default.
• W3043343913 creator A5031615704 @default.
• W3043343913 creator A5033073898 @default.
• W3043343913 creator A5040714564 @default.
• W3043343913 creator A5044264235 @default.
• W3043343913 creator A5045805871 @default.
• W3043343913 creator A5046643239 @default.
• W3043343913 creator A5049317200 @default.
• W3043343913 creator A5049947443 @default.
• W3043343913 creator A5053303084 @default.
• W3043343913 creator A5053603496 @default.
• W3043343913 creator A5060632471 @default.
• W3043343913 creator A5082504297 @default.
• W3043343913 creator A5087493059 @default.
• W3043343913 date "2020-07-20" @default.
• W3043343913 modified "2023-10-14" @default.
• W3043343913 title "Inhibition of the integrated stress response by viral proteins that block p-eIF2–eIF2B association" @default.
• W3043343913 cites W1488906799 @default.
• W3043343913 cites W1551930510 @default.
• W3043343913 cites W1604221682 @default.
• W3043343913 cites W1639028758 @default.
• W3043343913 cites W1970492983 @default.
• W3043343913 cites W1971859890 @default.
• W3043343913 cites W1972399884 @default.
• W3043343913 cites W1980374511 @default.
• W3043343913 cites W1980438612 @default.
• W3043343913 cites W1992481032 @default.
• W3043343913 cites W1999613945 @default.
• W3043343913 cites W2012652749 @default.
• W3043343913 cites W2019186980 @default.
• W3043343913 cites W2022605548 @default.
• W3043343913 cites W2025888779 @default.
• W3043343913 cites W2028401536 @default.
• W3043343913 cites W2032547866 @default.
• W3043343913 cites W2046278771 @default.
• W3043343913 cites W2048551040 @default.
• W3043343913 cites W2050456259 @default.
• W3043343913 cites W2052308758 @default.
• W3043343913 cites W2053943711 @default.
• W3043343913 cites W2065283382 @default.
• W3043343913 cites W2067040999 @default.
• W3043343913 cites W2067062024 @default.
• W3043343913 cites W2079838847 @default.
• W3043343913 cites W2086699218 @default.
• W3043343913 cites W2089555861 @default.
• W3043343913 cites W2099102700 @default.
• W3043343913 cites W2101386223 @default.
• W3043343913 cites W2102049218 @default.
• W3043343913 cites W2106952292 @default.
• W3043343913 cites W2112419844 @default.
• W3043343913 cites W2112503796 @default.
• W3043343913 cites W2127848114 @default.
• W3043343913 cites W2139987194 @default.
• W3043343913 cites W2144081927 @default.
• W3043343913 cites W2146256775 @default.
• W3043343913 cites W2157918066 @default.
• W3043343913 cites W2158419225 @default.
• W3043343913 cites W2167844024 @default.
• W3043343913 cites W2283649807 @default.
• W3043343913 cites W2518959324 @default.
• W3043343913 cites W2546157736 @default.
• W3043343913 cites W2596617684 @default.
• W3043343913 cites W2735295607 @default.
• W3043343913 cites W2775790403 @default.
• W3043343913 cites W2788135342 @default.
• W3043343913 cites W2794506661 @default.
• W3043343913 cites W2799524357 @default.
• W3043343913 cites W2800107604 @default.
• W3043343913 cites W2883916878 @default.
• W3043343913 cites W2906537904 @default.
• W3043343913 cites W2912998668 @default.
• W3043343913 cites W2921690345 @default.
• W3043343913 cites W4240290525 @default.
• W3043343913 doi "https://doi.org/10.1038/s41564-020-0759-0" @default.
• W3043343913 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32690955" @default.
• W3043343913 hasPublicationYear "2020" @default.
• W3043343913 type Work @default.
• W3043343913 sameAs 3043343913 @default.
• W3043343913 citedByCount "34" @default.
• W3043343913 countsByYear W30433439132020 @default.
• W3043343913 countsByYear W30433439132021 @default.
• W3043343913 countsByYear W30433439132022 @default.
• W3043343913 countsByYear W30433439132023 @default.
• W3043343913 crossrefType "journal-article" @default.
• W3043343913 hasAuthorship W3043343913A5001030335 @default.
• W3043343913 hasAuthorship W3043343913A5015172766 @default.
• W3043343913 hasAuthorship W3043343913A5019631651 @default.
• W3043343913 hasAuthorship W3043343913A5020538230 @default.
• W3043343913 hasAuthorship W3043343913A5031615704 @default.
• W3043343913 hasAuthorship W3043343913A5033073898 @default.
• W3043343913 hasAuthorship W3043343913A5040714564 @default.
• W3043343913 hasAuthorship W3043343913A5044264235 @default.
• W3043343913 hasAuthorship W3043343913A5045805871 @default.

• next