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- W3043358582 abstract "Since the beginning of 2020, the whole world has been struggling with the pandemic of Coronavirus Disease 2019 (COVID-19) caused by a novel coronavirus SARS-CoV-2. The SARS-CoV-2 infection depends on ACE2, TMPRSS2, and CD147, which are expressed on host cells. Several studies suggest that some single nucleotide polymorphisms (SNPs) of ACE2 might be a risk factor of COVID-19 infection. Genotypes affect ACE2 structure, its serum concentration, and levels of circulating angiotensin (1-7). Moreover, there is evidence that ACE genotype affects the outcomes of acute respiratory distress syndrome (ARDS) treatment, the most severe consequence of SARS-CoV-2 infection. COVID-19 morbidity, infection course, and mortality might depend on ACE D allele frequency. The aim of this narrative review was to analyze and identify the mechanisms of ACE-I and ARBs with particular emphasis on angiotensin receptors and their polymorphism in the light of COVID-19 pandemic as these medications are commonly prescribed to elderly patients. There is no direct evidence yet for ACE-I or ARBs in the treatment of COVID-19. However, for those already taking these medications, both the European Society of Cardiology and the American College of Cardiology recommend continuing the treatment, because at present, there is no clear clinical or scientific evidence to justify the discontinuation of ACE-I or ARBs. Individualized treatment decisions should be based on the clinical condition and co-morbidities of each patient." @default.
- W3043358582 created "2020-07-23" @default.
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- W3043358582 date "2020-07-01" @default.
- W3043358582 modified "2023-09-27" @default.
- W3043358582 title "<p>COVID-19: The Influence of ACE Genotype and ACE-I and ARBs on the Course of SARS-CoV-2 Infection in Elderly Patients</p>" @default.
- W3043358582 cites W1581300995 @default.
- W3043358582 cites W1766960367 @default.
- W3043358582 cites W1966238900 @default.
- W3043358582 cites W1980655557 @default.
- W3043358582 cites W1990235320 @default.
- W3043358582 cites W2000040025 @default.
- W3043358582 cites W2002765492 @default.
- W3043358582 cites W2005974032 @default.
- W3043358582 cites W2027171193 @default.
- W3043358582 cites W2028521865 @default.
- W3043358582 cites W2037927640 @default.
- W3043358582 cites W2048667592 @default.
- W3043358582 cites W2052521818 @default.
- W3043358582 cites W2064837935 @default.
- W3043358582 cites W2068814987 @default.
- W3043358582 cites W2071188333 @default.
- W3043358582 cites W2084441326 @default.
- W3043358582 cites W2104548316 @default.
- W3043358582 cites W2135794732 @default.
- W3043358582 cites W2136413073 @default.
- W3043358582 cites W2149146712 @default.
- W3043358582 cites W2159823033 @default.
- W3043358582 cites W2167384912 @default.
- W3043358582 cites W2344591421 @default.
- W3043358582 cites W2409683955 @default.
- W3043358582 cites W2441391782 @default.
- W3043358582 cites W2490786698 @default.
- W3043358582 cites W2503224871 @default.
- W3043358582 cites W2620972625 @default.
- W3043358582 cites W2625441704 @default.
- W3043358582 cites W2755474558 @default.
- W3043358582 cites W2882972976 @default.
- W3043358582 cites W2895798469 @default.
- W3043358582 cites W2896269788 @default.
- W3043358582 cites W2896886233 @default.
- W3043358582 cites W2898821382 @default.
- W3043358582 cites W2903899730 @default.
- W3043358582 cites W2935076315 @default.
- W3043358582 cites W2979596672 @default.
- W3043358582 cites W2981657433 @default.
- W3043358582 cites W2994488898 @default.
- W3043358582 cites W3003211833 @default.
- W3043358582 cites W3004465995 @default.
- W3043358582 cites W3006039930 @default.
- W3043358582 cites W3007683769 @default.
- W3043358582 cites W3008028633 @default.
- W3043358582 cites W3008590414 @default.
- W3043358582 cites W3008869844 @default.
- W3043358582 cites W3009351593 @default.
- W3043358582 cites W3009799538 @default.
- W3043358582 cites W3009885589 @default.
- W3043358582 cites W3009912996 @default.
- W3043358582 cites W3009941720 @default.
- W3043358582 cites W3010126769 @default.
- W3043358582 cites W3011016219 @default.
- W3043358582 cites W3011534780 @default.
- W3043358582 cites W3011792889 @default.
- W3043358582 cites W3011995143 @default.
- W3043358582 cites W3012699877 @default.
- W3043358582 cites W3012844803 @default.
- W3043358582 cites W3013529907 @default.
- W3043358582 cites W3015347450 @default.
- W3043358582 cites W3016250474 @default.
- W3043358582 cites W3016572296 @default.
- W3043358582 cites W3016839066 @default.
- W3043358582 cites W3017841804 @default.
- W3043358582 cites W3020166913 @default.
- W3043358582 cites W3020561822 @default.
- W3043358582 cites W3022438986 @default.
- W3043358582 cites W3023640683 @default.
- W3043358582 cites W3023751598 @default.
- W3043358582 cites W3023826646 @default.
- W3043358582 cites W3024420022 @default.
- W3043358582 cites W3025072975 @default.
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- W3043358582 doi "https://doi.org/10.2147/cia.s261516" @default.
- W3043358582 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7382582" @default.
- W3043358582 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32764907" @default.
- W3043358582 hasPublicationYear "2020" @default.
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