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• W3043367908 abstract "Abstract Sonogashira coupling between diversely substituted 2‐benzyloxy‐5‐bromopyrimidines and various aryl and aliphatic alkynes in the presence of catalytic amount of PdCl 2 (PPh 3 ) 2 with diethylamine and CuI as a co catalyst in THF at 60 °C afforded 17 new 2‐benzyloxy‐5‐alkyne substituted pyrimidines in good yields (85–94 %). The cytotoxic activity of resulted compounds were evaluated against A549 (Human lung adenocarcinoma cell line), HepG2 (Human liver cancer cell line) and HCT116 (Human colon cancer cell line) cancer cell lines. Some of the 2‐benzyloxy‐5‐alkyne pyrimidines synthesized were found to be shown moderate in vitro cytotoxic activity against A549 cell line." @default.
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• W3043367908 date "2020-07-15" @default.
• W3043367908 modified "2023-10-18" @default.
• W3043367908 title "Synthesis and Anticancer Activity of Some New 2‐Benzyloxy‐5‐alkyne Substituted Pyrimidines: An Application to Sonogashira Coupling" @default.
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• W3043367908 doi "https://doi.org/10.1002/slct.202001668" @default.
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