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- W3043374162 endingPage "1206" @default.
- W3043374162 startingPage "1198" @default.
- W3043374162 abstract "Abstract Fever in infections correlates with inflammation, macrophage infiltration into the affected organ, macrophage activation, and release of cytokines involved in immune response, hematopoiesis, and homeostatic processes. Angiotensin-converting enzyme 2 (ACE2) is the canonical cell surface receptor for SARS-CoV-2. ACE2 together with angiotensin receptor types 1 and 2 and ACE2 are components of the renin–angiotensin system (RAS). Exacerbated production of cytokines, mainly IL-6, points to macrophages as key to understand differential COVID-19 severity. SARS-CoV-2 may modulate macrophage-mediated inflammation events by altering the balance between angiotensin II, which activates angiotensin receptor types 1 and 2, and angiotensin 1–7 and alamandine, which activate MAS proto-oncogene and MAS-related D receptors, respectively. In addition to macrophages, lung cells express RAS components; also, some lung cells are able to produce IL-6. Addressing how SARS-CoV-2 unbalances RAS functionality via ACE2 will help design therapies to attenuate a COVID-19–related cytokine storm." @default.
- W3043374162 created "2020-07-23" @default.
- W3043374162 creator A5001784601 @default.
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- W3043374162 creator A5039996371 @default.
- W3043374162 creator A5043879414 @default.
- W3043374162 creator A5048432018 @default.
- W3043374162 date "2020-09-01" @default.
- W3043374162 modified "2023-10-06" @default.
- W3043374162 title "SARS-CoV-2 as a Factor to Disbalance the Renin–Angiotensin System: A Suspect in the Case of Exacerbated IL-6 Production" @default.
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