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• W3043395293 abstract "Restricted V(D)J recombination during fetal development was postulated to limit antibody repertoire breadth and prevent autoimmunity. However, newborn serum contains abundant autoantibodies, suggesting that B cell tolerance during gestation is not yet fully established. To investigate this apparent paradox, we evaluated the reactivities of more than 450 antibodies cloned from single B cells from human fetal liver, bone marrow, and spleen. We found that incomplete B cell tolerance in early human fetal life favored the accumulation of polyreactive B cells that bound both apoptotic cells and commensal bacteria from healthy adults. Thus, the restricted fetal preimmune repertoire contains potentially beneficial self-reactive innate-like B cell specificities that may facilitate the removal of apoptotic cells during development and shape gut microbiota assembly after birth." @default.
• W3043395293 created "2020-07-23" @default.
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• W3043395293 date "2020-07-17" @default.
• W3043395293 modified "2023-09-27" @default.
• W3043395293 title "Autoreactivity in naïve human fetal B cells is associated with commensal bacteria recognition" @default.
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• W3043395293 doi "https://doi.org/10.1126/science.aay9733" @default.
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