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- W3043401381 abstract "The clusters of differentiation (CD) are surface molecules used for immunophenotyping of cells. The expression of CD markers is widely used to classify hematological malignancies, including leukemia and lymphoma. Single nucleotide polymorphisms (SNPs) are crucial genetic changes that can be associated with abnormal expression and function of CD markers. In this paper, we assess the prognostic effect of CD markers' SNPs in hematological malignancies. Materials and methods and relevant literature was identified by a PubMed search (2001-2019) of English language papers using the following terms: 'polymorphism', 'CD marker', 'leukemia', 'lymphoma', 'prognosis', 'CD marker', and 'polymorphism'. Many studies have demonstrated the effects of CD markers' polymorphisms on risk of hematological malignancies. Also, SNPs of CD markers can be related with clinicopathological features, invasiveness, and response to therapy of these disorders. Considering the importance of SNPs in the expressions of CD markers, these genetic changes could be used as potential prognostic biomarkers in hematological malignancies. It is hoped that the evaluation of SNPs in CD markers will enable early diagnosis, prognosis, and detection of response to treatment. However, better understanding of SNPs in CD markers that are involved in hematological malignancies requires further studies on different populations of the worldwide." @default.
- W3043401381 created "2020-07-23" @default.
- W3043401381 creator A5002465245 @default.
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- W3043401381 creator A5007897879 @default.
- W3043401381 creator A5081643573 @default.
- W3043401381 creator A5081683169 @default.
- W3043401381 date "2020-07-14" @default.
- W3043401381 modified "2023-09-27" @default.
- W3043401381 title "CD markers polymorphisms as prognostic biomarkers in hematological malignancies" @default.
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- W3043401381 doi "https://doi.org/10.4081/oncol.2020.466" @default.
- W3043401381 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7385526" @default.
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- W3043401381 hasPublicationYear "2020" @default.
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