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• W3043445900 abstract "Background Cardiac right ventricular remodeling plays a substantial role in pathogenesis, progression, and prognosis of pulmonary hypertension. Cardiac magnetic resonance is considered an excellent tool for evaluation of right ventricle. However, value of right ventricular remodeling parameters derived from cardiac magnetic resonance in predicting adverse events is controversial. Methods The Pubmed (MEDLINE), Embase, Cochrane Library, Web of Science, China National Knowledge Infrastructure platform (CNKI), China Science and Technology Journal Database (VIP), and Wanfang databases were systematically searched until November 2019. Studies reporting hazard ratios (HRs) for all-cause death and composite end point of pulmonary hypertension were included. Univariate HRs were extracted from the included studies to calculate pooled HRs of each right ventricular remodeling parameter. Results Eight studies with 1120 patients examining all-cause death (female: 44%–92%, age: 40–67 years old, follow-up time: 27–48 months) and 10 studies with 604 patients examining composite end point (female: 60%–83%, age: 29–57 years old, follow-up time: 10–68 months) met the criteria. Right ventricular ejection fraction was the only parameter which could predict both all-cause death (pooled HR=0.95; P =0.014) and composite end point (pooled HR=0.95; P <0.001), although right ventricular end-diastolic volume index (pooled HR=1.01; P <0.001), right ventricular end-systolic volume index (pooled HR=1.01, P =0.045), and right ventricular mass index (pooled HR=1.03, P =0.032) only predicted composite outcome. Similar results were observed when we conducted the meta-analysis among patients with World Health Organization type I of pulmonary hypertension. Conclusions Cardiac magnetic resonance–derived right ventricular remodeling parameters have independent prognostic value for all-cause death and composite end point of patients with pulmonary hypertension. Right ventricular ejection fraction was the strongest prognostic factor among all the right ventricular remodeling parameters. Right ventricular mass index, right ventricular end-diastolic volume index, and right ventricular end-systolic volume index also demonstrated prognostic value." @default.
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• W3043445900 date "2020-07-01" @default.
• W3043445900 modified "2023-10-12" @default.
• W3043445900 title "Prognostic Value of Cardiac Magnetic Resonance–Derived Right Ventricular Remodeling Parameters in Pulmonary Hypertension" @default.
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• W3043445900 doi "https://doi.org/10.1161/circimaging.120.010568" @default.
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