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- W3043459168 abstract "Age is the only one non-modifiable risk of cerebral ischemia. Advances in stroke medicine and behavioral adaptation to stroke risk factors and comorbidities was successful in decreasing stroke incidence and increasing the number of stroke survivors in western societies. Comorbidities aggravates the outcome after cerebral ischemia. However, due to the increased in number of elderly, the incidence of stroke has increased again paralleled by an increase in the number of stroke survivors, many with severe disabilities, that has led to an increased economic and social burden in society. Animal models of stroke often ignore age and comorbidities frequently associated with senescence. This might explain why drugs working nicely in animal models fail to show efficacy in stroke survivors. Since stroke afflicts mostly the elderly comorbid patients, it is highly desirable to test the efficacy of stroke therapies in an appropriate animal stroke model. Therefore, in this review, we make parallels between animal models of stroke und clinical data and summarize the impact of ageing and age-related comorbidities on stroke outcome." @default.
- W3043459168 created "2020-07-23" @default.
- W3043459168 creator A5004951769 @default.
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- W3043459168 creator A5050027988 @default.
- W3043459168 creator A5057010928 @default.
- W3043459168 creator A5068091656 @default.
- W3043459168 date "2020-09-01" @default.
- W3043459168 modified "2023-10-16" @default.
- W3043459168 title "Ageing as a risk factor for cerebral ischemia: Underlying mechanisms and therapy in animal models and in the clinic" @default.
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