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- W3043463165 abstract "Aim: Investigation of characteristics of different duodenal microbial colonization states in patients with liver cirrhosis (LC). Materials & methods: Deep-sequencing analyses of the 16S rRNA gene V1-V3 regions were performed. Results: Both bacterial compositions and richness were different between the three-clustered LC microbiotas, in other words, Cluster_1_LC, Cluster_2_LC and Cluster_3_LC. Cluster_1_LC were more likely at severe dysbiosis status due to its lowest modified cirrhosis dysbiosis ratio. OTU12_ Prevotella and OTU10_ Comamonas were most associated with Cluster_1_LC and Cluster_3_LC, respectively, while OTU38_ Alloprevotella was vital in Cluster_2_LC. Pyruvate-ferredoxin/flavodoxin oxidoreductase, dihydroorotate dehydrogenase and branched-chain amino acid transport system substrate-binding protein were most associated with Cluster_1_LC, Cluster_2_LC and Cluster_3_LC, respectively. Conclusion: The three duodenal microbial colonization states had distinct representative characteristics, which might reflect the health status of cirrhotic patients." @default.
- W3043463165 created "2020-07-23" @default.
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- W3043463165 date "2020-07-01" @default.
- W3043463165 modified "2023-09-23" @default.
- W3043463165 title "Characteristics of three microbial colonization states in the duodenum of the cirrhotic patients" @default.
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- W3043463165 doi "https://doi.org/10.2217/fmb-2019-0270" @default.
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