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- W3043470522 endingPage "100740" @default.
- W3043470522 startingPage "100740" @default.
- W3043470522 abstract "Cellular membranes are critical platforms for intracellular signaling that involve complex interfaces between lipids and proteins, and a web of interactions between a multitude of lipid metabolic pathways. Membrane lipids impart structural and functional information in this regulatory circuit that encompass biophysical parameters such as membrane thickness and fluidity, as well as chaperoning the interactions of protein binding partners. Phosphatidylinositol and its phosphorylated derivatives, the phosphoinositides, play key roles in intracellular membrane signaling, and these involvements are translated into an impressively diverse set of biological outcomes. The phosphatidylinositol transfer proteins (PITPs) are key regulators of phosphoinositide signaling. Found in a diverse array of organisms from plants, yeast and apicomplexan parasites to mammals, PITPs were initially proposed to be simple transporters of lipids between intracellular membranes. It now appears increasingly unlikely that the soluble versions of these proteins perform such functions within the cell. Rather, these serve to facilitate the activity of intrinsically biologically insufficient inositol lipid kinases and, in so doing, promote diversification of the biological outcomes of phosphoinositide signaling. The central engine for execution of such functions is the lipid exchange cycle that is a fundamental property of PITPs. How PITPs execute lipid exchange remains very poorly understood. Molecular dynamics simulation approaches are now providing the first atomistic insights into how PITPs, and potentially other lipid-exchange/transfer proteins, operate." @default.
- W3043470522 created "2020-07-23" @default.
- W3043470522 creator A5005317904 @default.
- W3043470522 creator A5022522725 @default.
- W3043470522 creator A5027834080 @default.
- W3043470522 creator A5028663579 @default.
- W3043470522 creator A5085155459 @default.
- W3043470522 date "2020-12-01" @default.
- W3043470522 modified "2023-10-16" @default.
- W3043470522 title "Lipid transfer proteins and instructive regulation of lipid kinase activities: Implications for inositol lipid signaling and disease" @default.
- W3043470522 cites W1042686957 @default.
- W3043470522 cites W127182181 @default.
- W3043470522 cites W1499176799 @default.
- W3043470522 cites W1501088201 @default.
- W3043470522 cites W1538989554 @default.
- W3043470522 cites W1554766623 @default.
- W3043470522 cites W1566522647 @default.
- W3043470522 cites W1568605582 @default.
- W3043470522 cites W1605146346 @default.
- W3043470522 cites W1791002731 @default.
- W3043470522 cites W1793858878 @default.
- W3043470522 cites W1901403788 @default.
- W3043470522 cites W1951183643 @default.
- W3043470522 cites W1963354829 @default.
- W3043470522 cites W1964679889 @default.
- W3043470522 cites W1965441259 @default.
- W3043470522 cites W1966975426 @default.
- W3043470522 cites W1969799718 @default.
- W3043470522 cites W1969806493 @default.
- W3043470522 cites W1970242079 @default.
- W3043470522 cites W1971476012 @default.
- W3043470522 cites W1971492455 @default.
- W3043470522 cites W1971679075 @default.
- W3043470522 cites W1972044172 @default.
- W3043470522 cites W1972753570 @default.
- W3043470522 cites W1973593487 @default.
- W3043470522 cites W1974006660 @default.
- W3043470522 cites W1975056846 @default.
- W3043470522 cites W1975543728 @default.
- W3043470522 cites W1975642651 @default.
- W3043470522 cites W1976398980 @default.
- W3043470522 cites W1976489799 @default.
- W3043470522 cites W1977197102 @default.
- W3043470522 cites W1977755877 @default.
- W3043470522 cites W1977889337 @default.
- W3043470522 cites W1978079881 @default.
- W3043470522 cites W1979104861 @default.
- W3043470522 cites W1980188948 @default.
- W3043470522 cites W1980939512 @default.
- W3043470522 cites W1981188183 @default.
- W3043470522 cites W1981983543 @default.
- W3043470522 cites W1984017224 @default.
- W3043470522 cites W1984630839 @default.
- W3043470522 cites W1986709440 @default.
- W3043470522 cites W1987086612 @default.
- W3043470522 cites W1988196067 @default.
- W3043470522 cites W1989433761 @default.
- W3043470522 cites W1989482362 @default.
- W3043470522 cites W1991655565 @default.
- W3043470522 cites W1993277813 @default.
- W3043470522 cites W1994803385 @default.
- W3043470522 cites W1996114497 @default.
- W3043470522 cites W1996335333 @default.
- W3043470522 cites W1996803437 @default.
- W3043470522 cites W1996977823 @default.
- W3043470522 cites W1998384937 @default.
- W3043470522 cites W1999768397 @default.
- W3043470522 cites W2001683286 @default.
- W3043470522 cites W2001837228 @default.
- W3043470522 cites W2001862736 @default.
- W3043470522 cites W2001956269 @default.
- W3043470522 cites W2002292732 @default.
- W3043470522 cites W2002341882 @default.
- W3043470522 cites W2003190277 @default.
- W3043470522 cites W2004530752 @default.
- W3043470522 cites W2005445415 @default.
- W3043470522 cites W2005962295 @default.
- W3043470522 cites W2006237582 @default.
- W3043470522 cites W2007270198 @default.
- W3043470522 cites W2007991169 @default.
- W3043470522 cites W2010093307 @default.
- W3043470522 cites W2011447168 @default.
- W3043470522 cites W2012462364 @default.
- W3043470522 cites W2012859794 @default.
- W3043470522 cites W2013071061 @default.
- W3043470522 cites W2014137216 @default.
- W3043470522 cites W2014808628 @default.
- W3043470522 cites W2015140940 @default.
- W3043470522 cites W2015488410 @default.
- W3043470522 cites W2017499074 @default.
- W3043470522 cites W2017754921 @default.
- W3043470522 cites W2018415759 @default.
- W3043470522 cites W2018714533 @default.
- W3043470522 cites W2018762738 @default.
- W3043470522 cites W2019442017 @default.
- W3043470522 cites W2021882008 @default.
- W3043470522 cites W2022013116 @default.
- W3043470522 cites W2022421070 @default.