Matches in SemOpenAlex for { <https://semopenalex.org/work/W3043474991> ?p ?o ?g. }
- W3043474991 endingPage "959" @default.
- W3043474991 startingPage "951" @default.
- W3043474991 abstract "The aim of this study was to identify the minimal essential co-expression and physical interaction networks involved in the development of cognition impairment in human mid and late life. We searched the Online Mendelian Inheritance in Man (OMIM) database to extract the validated human genes annotated (until March 2020) for five major disorders of pathophysiological overlap and sequential chronological occurrence in human, including multiple sclerosis, type 2 diabetes mellitus, Alzheimer’s disease, vascular dementia, and Lewy body dementia. Gene co-expression and physical interaction networks were subsequently constructed for the overlapping genes across the selected disorders. Remarkably, each of the gene co-expression and physical interaction networks consisted of single clusters (P = 0.0005 and P = 1 × 10−16, respectively). APP was the major hub in the integrated and tissue-specific co-expression networks, whereas insulin was the major hub in the physical interaction network. Several other hubs were identified across the identified networks, including TNF, VEGFA, GAPDH, and NOTCH1. We propose the minimal co-expression and physical interaction networks and their single clustering in the development of cognition impairment in human mid and late life. This is a pilot study, warranting identification of more risk genes, using additional validated databases in the future." @default.
- W3043474991 created "2020-07-23" @default.
- W3043474991 creator A5042797060 @default.
- W3043474991 creator A5056953085 @default.
- W3043474991 creator A5080519063 @default.
- W3043474991 creator A5083282499 @default.
- W3043474991 date "2020-07-16" @default.
- W3043474991 modified "2023-09-24" @default.
- W3043474991 title "Proposed minimal essential co-expression and physical interaction networks involved in the development of cognition impairment in human mid and late life" @default.
- W3043474991 cites W1985213868 @default.
- W3043474991 cites W2015919242 @default.
- W3043474991 cites W2016010585 @default.
- W3043474991 cites W2035882804 @default.
- W3043474991 cites W2067203120 @default.
- W3043474991 cites W2072856387 @default.
- W3043474991 cites W2095370244 @default.
- W3043474991 cites W2131665068 @default.
- W3043474991 cites W2137518425 @default.
- W3043474991 cites W2294456253 @default.
- W3043474991 cites W2534390616 @default.
- W3043474991 cites W2548833686 @default.
- W3043474991 cites W2582418772 @default.
- W3043474991 cites W2597026225 @default.
- W3043474991 cites W2626854720 @default.
- W3043474991 cites W2749129326 @default.
- W3043474991 cites W2766248450 @default.
- W3043474991 cites W2884134082 @default.
- W3043474991 cites W2886380990 @default.
- W3043474991 cites W2888308652 @default.
- W3043474991 cites W2889666218 @default.
- W3043474991 cites W2898215177 @default.
- W3043474991 cites W2900569176 @default.
- W3043474991 cites W2900967956 @default.
- W3043474991 cites W2903766786 @default.
- W3043474991 cites W2907629875 @default.
- W3043474991 cites W2912841818 @default.
- W3043474991 cites W2913638709 @default.
- W3043474991 cites W2922203379 @default.
- W3043474991 cites W2922712727 @default.
- W3043474991 cites W2929623625 @default.
- W3043474991 cites W2942433516 @default.
- W3043474991 cites W2946354647 @default.
- W3043474991 cites W2950764390 @default.
- W3043474991 cites W2957509960 @default.
- W3043474991 cites W2967004347 @default.
- W3043474991 cites W2969098115 @default.
- W3043474991 cites W2972593320 @default.
- W3043474991 cites W2981624110 @default.
- W3043474991 cites W2986773415 @default.
- W3043474991 cites W2993838776 @default.
- W3043474991 cites W2995669480 @default.
- W3043474991 cites W3000071564 @default.
- W3043474991 cites W3001096019 @default.
- W3043474991 cites W3013825676 @default.
- W3043474991 cites W3020969316 @default.
- W3043474991 cites W3021793018 @default.
- W3043474991 doi "https://doi.org/10.1007/s10072-020-04594-0" @default.
- W3043474991 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32676761" @default.
- W3043474991 hasPublicationYear "2020" @default.
- W3043474991 type Work @default.
- W3043474991 sameAs 3043474991 @default.
- W3043474991 citedByCount "1" @default.
- W3043474991 countsByYear W30434749912021 @default.
- W3043474991 crossrefType "journal-article" @default.
- W3043474991 hasAuthorship W3043474991A5042797060 @default.
- W3043474991 hasAuthorship W3043474991A5056953085 @default.
- W3043474991 hasAuthorship W3043474991A5080519063 @default.
- W3043474991 hasAuthorship W3043474991A5083282499 @default.
- W3043474991 hasBestOaLocation W30434749911 @default.
- W3043474991 hasConcept C118552586 @default.
- W3043474991 hasConcept C142724271 @default.
- W3043474991 hasConcept C15744967 @default.
- W3043474991 hasConcept C16568411 @default.
- W3043474991 hasConcept C169760540 @default.
- W3043474991 hasConcept C169900460 @default.
- W3043474991 hasConcept C2779134260 @default.
- W3043474991 hasConcept C2779483572 @default.
- W3043474991 hasConcept C2780640218 @default.
- W3043474991 hasConcept C60644358 @default.
- W3043474991 hasConcept C70721500 @default.
- W3043474991 hasConcept C71924100 @default.
- W3043474991 hasConcept C86803240 @default.
- W3043474991 hasConceptScore W3043474991C118552586 @default.
- W3043474991 hasConceptScore W3043474991C142724271 @default.
- W3043474991 hasConceptScore W3043474991C15744967 @default.
- W3043474991 hasConceptScore W3043474991C16568411 @default.
- W3043474991 hasConceptScore W3043474991C169760540 @default.
- W3043474991 hasConceptScore W3043474991C169900460 @default.
- W3043474991 hasConceptScore W3043474991C2779134260 @default.
- W3043474991 hasConceptScore W3043474991C2779483572 @default.
- W3043474991 hasConceptScore W3043474991C2780640218 @default.
- W3043474991 hasConceptScore W3043474991C60644358 @default.
- W3043474991 hasConceptScore W3043474991C70721500 @default.
- W3043474991 hasConceptScore W3043474991C71924100 @default.
- W3043474991 hasConceptScore W3043474991C86803240 @default.
- W3043474991 hasIssue "3" @default.
- W3043474991 hasLocation W30434749911 @default.
- W3043474991 hasOpenAccess W3043474991 @default.