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- W3043480372 endingPage "107631" @default.
- W3043480372 startingPage "107631" @default.
- W3043480372 abstract "The Bromo- and Extra-Terminal domain (BET) family proteins act as “readers” of acetylated histones and they are important transcription regulators. BRD2, BRD3, BRD4 and BRDT, part of the BET family, are important in different tumors, where upregulation or translocation often occurs. The potential of targeting BET proteins as anti-cancer treatment originated with data obtained with a first series of compounds, and there are now several data supporting BET inhibition in both solid tumors and hematological malignancies. Despite very positive preclinical data in different tumor types, the clinical results have been so far moderate. Using lymphoma as an example to review the data produced in the laboratory and in the context of the early clinical trials, we discuss the modalities to make BET targeting more efficient both generating novel generation of compounds and by exploring the combination with small molecules affecting various signaling pathways, BCL2, or DNA damage response signaling, but also with additional epigenetic agents and with immunotherapy. We also discuss the mechanisms of resistance and the toxicity profiles so far reported." @default.
- W3043480372 created "2020-07-23" @default.
- W3043480372 creator A5038420682 @default.
- W3043480372 creator A5048622832 @default.
- W3043480372 creator A5066518317 @default.
- W3043480372 date "2020-11-01" @default.
- W3043480372 modified "2023-10-01" @default.
- W3043480372 title "Targeting BET bromodomain proteins in cancer: The example of lymphomas" @default.
- W3043480372 cites W1238891688 @default.
- W3043480372 cites W1482784375 @default.
- W3043480372 cites W1488181101 @default.
- W3043480372 cites W1502629510 @default.
- W3043480372 cites W1565539350 @default.
- W3043480372 cites W1581511725 @default.
- W3043480372 cites W1625510017 @default.
- W3043480372 cites W1945032888 @default.
- W3043480372 cites W1951627305 @default.
- W3043480372 cites W1965604161 @default.
- W3043480372 cites W1971578941 @default.
- W3043480372 cites W1973462980 @default.
- W3043480372 cites W1974487011 @default.
- W3043480372 cites W1979404155 @default.
- W3043480372 cites W1986354050 @default.
- W3043480372 cites W1986743724 @default.
- W3043480372 cites W1989069691 @default.
- W3043480372 cites W1998805995 @default.
- W3043480372 cites W2001619812 @default.
- W3043480372 cites W2002395443 @default.
- W3043480372 cites W2002730815 @default.
- W3043480372 cites W2004835054 @default.
- W3043480372 cites W2004966039 @default.
- W3043480372 cites W2009631763 @default.
- W3043480372 cites W2009826707 @default.
- W3043480372 cites W2009949436 @default.
- W3043480372 cites W2022932992 @default.
- W3043480372 cites W2027417589 @default.
- W3043480372 cites W2029903254 @default.
- W3043480372 cites W2032365395 @default.
- W3043480372 cites W2041535798 @default.
- W3043480372 cites W2044082037 @default.
- W3043480372 cites W2044874589 @default.
- W3043480372 cites W2046816028 @default.
- W3043480372 cites W2047790609 @default.
- W3043480372 cites W2049005444 @default.
- W3043480372 cites W2052692973 @default.
- W3043480372 cites W2052787205 @default.
- W3043480372 cites W2054777324 @default.
- W3043480372 cites W2057325460 @default.
- W3043480372 cites W2057460011 @default.
- W3043480372 cites W2060484997 @default.
- W3043480372 cites W2062424910 @default.
- W3043480372 cites W2069695937 @default.
- W3043480372 cites W2069909921 @default.
- W3043480372 cites W2080910217 @default.
- W3043480372 cites W2086509569 @default.
- W3043480372 cites W2090714945 @default.
- W3043480372 cites W2096673680 @default.
- W3043480372 cites W2103409409 @default.
- W3043480372 cites W2104706142 @default.
- W3043480372 cites W2113056756 @default.
- W3043480372 cites W2118428599 @default.
- W3043480372 cites W2120572492 @default.
- W3043480372 cites W2125828985 @default.
- W3043480372 cites W2126730534 @default.
- W3043480372 cites W2128151873 @default.
- W3043480372 cites W2128605424 @default.
- W3043480372 cites W2129129812 @default.
- W3043480372 cites W2137429553 @default.
- W3043480372 cites W2149441684 @default.
- W3043480372 cites W2152979497 @default.
- W3043480372 cites W2153056550 @default.
- W3043480372 cites W2154924534 @default.
- W3043480372 cites W2157228274 @default.
- W3043480372 cites W2160076049 @default.
- W3043480372 cites W2162520885 @default.
- W3043480372 cites W2167732604 @default.
- W3043480372 cites W2169287961 @default.
- W3043480372 cites W2176682109 @default.
- W3043480372 cites W2193786745 @default.
- W3043480372 cites W2205700110 @default.
- W3043480372 cites W2227431445 @default.
- W3043480372 cites W2237475663 @default.
- W3043480372 cites W2294961516 @default.
- W3043480372 cites W2299219969 @default.
- W3043480372 cites W2300442403 @default.
- W3043480372 cites W2417546716 @default.
- W3043480372 cites W2471089142 @default.
- W3043480372 cites W2476685579 @default.
- W3043480372 cites W2477271322 @default.
- W3043480372 cites W2508616096 @default.
- W3043480372 cites W2520148131 @default.
- W3043480372 cites W2544359401 @default.
- W3043480372 cites W2557119566 @default.
- W3043480372 cites W2557763600 @default.
- W3043480372 cites W2558696992 @default.
- W3043480372 cites W2559419629 @default.
- W3043480372 cites W2571046561 @default.
- W3043480372 cites W2574795782 @default.