Matches in SemOpenAlex for { <https://semopenalex.org/work/W3043504219> ?p ?o ?g. }
- W3043504219 abstract "The Cambrian explosion was a unique animal radiation ~540 million years ago that produced the full range of body plans across bilaterians. The genetic mechanisms underlying these events are unknown, leaving a fundamental question in evolutionary biology unanswered. Using large-scale comparative genomics and advanced orthology evaluation techniques, we identified 157 bilaterian-specific genes. They include the entire Nodal pathway, a key regulator of mesoderm development and left-right axis specification; components for nervous system development, including a suite of G-protein-coupled receptors that control physiology and behaviour, the Robo-Slit midline repulsion system, and the neurotrophin signalling system; a high number of zinc finger transcription factors; and novel factors that previously escaped attention. Contradicting the current view, our study reveals that genes with bilaterian origin are robustly associated with key features in extant bilaterians, suggesting a causal relationship." @default.
- W3043504219 created "2020-07-23" @default.
- W3043504219 creator A5023321182 @default.
- W3043504219 creator A5039891730 @default.
- W3043504219 creator A5052761519 @default.
- W3043504219 creator A5058228077 @default.
- W3043504219 creator A5067935909 @default.
- W3043504219 date "2020-07-16" @default.
- W3043504219 modified "2023-10-16" @default.
- W3043504219 title "The genetic factors of bilaterian evolution" @default.
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