Matches in SemOpenAlex for { <https://semopenalex.org/work/W3043505524> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W3043505524 abstract "Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive fibrosing interstitial pneumonia, resulting in chronic respiratoryfailure and eventually death. β -catenin/Foxo1 showed a protective property in kidney fibrosis, but the role of β -catenin/Foxo1 in IPF was unclear. Our study aimed to investigate the role of β -catenin/Foxo1 in IPF and explore its underlying mechanism. The IPF model was established by injection of bleomycin (BLM) in vivo and stimulation by TGF- β 1 in MRC5 cell in vitro. Haematoxylin-eosin staining and Masson’s trichrome staining were performed to examine histopathological injury in lung. Protein expression of corresponding genes was detected using western blot. Immunofluorescence staining assay was carried out to detect the expression of β -catenin, Foxo1, TCF and α -SMA. The expression levels of inflammatory cytokines were determined using ELISA kit assay. The results showed that BLM induced a serious pulmonary injury and proliferated fibroblasts. A higher interaction of β -catenin with TCF and a lower interaction of β -catenin with Foxo1 was found in BLM group compared to the control group. TGF- β 1 promoted β -catenin/TCF, whereas ICG-001 inhibited β -catenin/TCF, and promoted β -catenin/Foxo1. Furthermore, ICG-001 reversed TGF- β 1 induced largely production of inflammatory cytokines and accumulation of extracellular matrix, as well as high expression of α -SMA. However, AS1842856, a FOXO1 antagonist, strengthened the effects induced by TGF- β 1. In summary, our study revealed that β -catenin/Foxo1 protected against IPF through inhibiting inflammatory response and extracellular matrix accumulation, providing an alternative approach to explain the potential mechanism of IPF and seek for more effective therapeutic drugs." @default.
- W3043505524 created "2020-07-23" @default.
- W3043505524 creator A5047195259 @default.
- W3043505524 creator A5061426227 @default.
- W3043505524 creator A5077070724 @default.
- W3043505524 creator A5082415735 @default.
- W3043505524 date "2020-02-01" @default.
- W3043505524 modified "2023-09-28" @default.
- W3043505524 title "Enhanced β-Catenin/Foxo1 Activity Alleviates Pulmonary Fibrosis by Inhibiting β-Catenin/T Cell Factor Signaling" @default.
- W3043505524 doi "https://doi.org/10.1166/jbt.2020.2241" @default.
- W3043505524 hasPublicationYear "2020" @default.
- W3043505524 type Work @default.
- W3043505524 sameAs 3043505524 @default.
- W3043505524 citedByCount "0" @default.
- W3043505524 crossrefType "journal-article" @default.
- W3043505524 hasAuthorship W3043505524A5047195259 @default.
- W3043505524 hasAuthorship W3043505524A5061426227 @default.
- W3043505524 hasAuthorship W3043505524A5077070724 @default.
- W3043505524 hasAuthorship W3043505524A5082415735 @default.
- W3043505524 hasConcept C126322002 @default.
- W3043505524 hasConcept C137620995 @default.
- W3043505524 hasConcept C140149449 @default.
- W3043505524 hasConcept C142724271 @default.
- W3043505524 hasConcept C185592680 @default.
- W3043505524 hasConcept C189165786 @default.
- W3043505524 hasConcept C190283241 @default.
- W3043505524 hasConcept C2777714996 @default.
- W3043505524 hasConcept C2778341716 @default.
- W3043505524 hasConcept C2780559512 @default.
- W3043505524 hasConcept C2781244666 @default.
- W3043505524 hasConcept C30145163 @default.
- W3043505524 hasConcept C502942594 @default.
- W3043505524 hasConcept C55493867 @default.
- W3043505524 hasConcept C62478195 @default.
- W3043505524 hasConcept C71924100 @default.
- W3043505524 hasConcept C75217442 @default.
- W3043505524 hasConceptScore W3043505524C126322002 @default.
- W3043505524 hasConceptScore W3043505524C137620995 @default.
- W3043505524 hasConceptScore W3043505524C140149449 @default.
- W3043505524 hasConceptScore W3043505524C142724271 @default.
- W3043505524 hasConceptScore W3043505524C185592680 @default.
- W3043505524 hasConceptScore W3043505524C189165786 @default.
- W3043505524 hasConceptScore W3043505524C190283241 @default.
- W3043505524 hasConceptScore W3043505524C2777714996 @default.
- W3043505524 hasConceptScore W3043505524C2778341716 @default.
- W3043505524 hasConceptScore W3043505524C2780559512 @default.
- W3043505524 hasConceptScore W3043505524C2781244666 @default.
- W3043505524 hasConceptScore W3043505524C30145163 @default.
- W3043505524 hasConceptScore W3043505524C502942594 @default.
- W3043505524 hasConceptScore W3043505524C55493867 @default.
- W3043505524 hasConceptScore W3043505524C62478195 @default.
- W3043505524 hasConceptScore W3043505524C71924100 @default.
- W3043505524 hasConceptScore W3043505524C75217442 @default.
- W3043505524 hasLocation W30435055241 @default.
- W3043505524 hasOpenAccess W3043505524 @default.
- W3043505524 hasPrimaryLocation W30435055241 @default.
- W3043505524 hasRelatedWork W10105718 @default.
- W3043505524 hasRelatedWork W12450125 @default.
- W3043505524 hasRelatedWork W12655370 @default.
- W3043505524 hasRelatedWork W1613308 @default.
- W3043505524 hasRelatedWork W4317196 @default.
- W3043505524 hasRelatedWork W8834295 @default.
- W3043505524 hasRelatedWork W9353498 @default.
- W3043505524 hasRelatedWork W9483995 @default.
- W3043505524 hasRelatedWork W11657417 @default.
- W3043505524 hasRelatedWork W6778869 @default.
- W3043505524 isParatext "false" @default.
- W3043505524 isRetracted "false" @default.
- W3043505524 magId "3043505524" @default.
- W3043505524 workType "article" @default.