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- W3043505976 abstract "Objectives The current study focused on the evaluation of the cytotoxic effect and permeability of ziprasidone hydrochloride monohydrate (ZHM) nanocrystals on Caco-2 cells. Materials and methods ZHM nanocrystals were prepared by the microfluidization method in the presence of polyvinylpyrrolidone as a stabilizer. Particle size (PS), particle size distribution (PDI), and zeta potential (ZP) values were measured in characterization studies. In vitro cytotoxic effects of ZHM nanocrystals were investigated using the 3-(4,5-dimetylthiazol-2-yl)-2,5-diphenyltetrazolium bromide test. Caco-2 transport studies were conducted with formulations of ZHM coarse powder and nanocrystals. Results Nanocrystals were obtained with 400-600 nm PS, 0.1-0.4 PDI, and >20 mV ZP values. The cell viability remained 100% for all sample groups. The permeability value of ZHM nanocrystals through Caco-2 cells increased 2.3-fold in comparison with ZHM coarse powder. Cumulative drug transport also increased at the end of the sampling period. Conclusion Nanocrystal technology helps to increase the permeability of drug particles by increasing the saturation solubility." @default.
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- W3043505976 date "2021-04-20" @default.
- W3043505976 modified "2023-10-16" @default.
- W3043505976 title "<i>In Vitro</i> Caco-2 Cell Permeability Studies of Ziprasidone Hydrochloride Monohydrate Nanocrystals" @default.
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- W3043505976 doi "https://doi.org/10.4274/tjps.galenos.2020.67366" @default.
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