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• W3043505992 abstract "There remains an unmet need to address the substantial morbidity and mortality associated with severe community-acquired pneumonia (sCAP). Recombinant human plasma gelsolin (rhu-pGSN) improves disease outcomes in diverse animal models of infectious and noninfectious inflammation. This blinded dose-escalation safety study involved non-intensive care unit (ICU) patients admitted for mild CAP and randomized 3:1 to receive adjunctive rhu-pGSN or placebo intravenously. Thirty-three subjects were treated: 8 in the single-dose phase and 25 in the multidose phase." @default.
• W3043505992 created "2020-07-23" @default.
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• W3043505992 date "2020-09-21" @default.
• W3043505992 modified "2023-09-23" @default.
• W3043505992 title "Safety and Pharmacokinetics of Recombinant Human Plasma Gelsolin in Patients Hospitalized for Nonsevere Community-Acquired Pneumonia" @default.
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• W3043505992 doi "https://doi.org/10.1128/aac.00579-20" @default.
• W3043505992 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7508610" @default.
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• W3043505992 hasPublicationYear "2020" @default.
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