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• W3043544802 endingPage "18590" @default.
• W3043544802 startingPage "18582" @default.
• W3043544802 abstract "Cells consist of molecular modules which perform vital biological functions. Cellular modules are key units of adaptive evolution because organismal fitness depends on their performance. Theory shows that in rapidly evolving populations, such as those of many microbes, adaptation is driven primarily by common beneficial mutations with large effects, while other mutations behave as if they are effectively neutral. As a consequence, if a module can be improved only by rare and/or weak beneficial mutations, its adaptive evolution would stall. However, such evolutionary stalling has not been empirically demonstrated, and it is unclear to what extent stalling may limit the power of natural selection to improve modules. Here we empirically characterize how natural selection improves the translation machinery (TM), an essential cellular module. We experimentally evolved populations of Escherichia coli with genetically perturbed TMs for 1,000 generations. Populations with severe TM defects initially adapted via mutations in the TM, but TM adaptation stalled within about 300 generations. We estimate that the genetic load in our populations incurred by residual TM defects ranges from 0.5 to 19%. Finally, we found evidence that both epistasis and the depletion of the pool of beneficial mutations contributed to evolutionary stalling. Our results suggest that cellular modules may not be fully optimized by natural selection despite the availability of adaptive mutations." @default.
• W3043544802 created "2020-07-23" @default.
• W3043544802 creator A5027282332 @default.
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• W3043544802 creator A5080535115 @default.
• W3043544802 creator A5085573285 @default.
• W3043544802 date "2020-07-17" @default.
• W3043544802 modified "2023-10-16" @default.
• W3043544802 title "Evolutionary stalling and a limit on the power of natural selection to improve a cellular module" @default.
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• W3043544802 doi "https://doi.org/10.1073/pnas.1921881117" @default.
• W3043544802 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7414050" @default.
• W3043544802 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32680961" @default.
• W3043544802 hasPublicationYear "2020" @default.
• W3043544802 type Work @default.
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