FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3043546620> ?p ?o ?g. }

• W3043546620 endingPage "101958" @default.
• W3043546620 startingPage "101958" @default.
• W3043546620 abstract "One of the significant challenges to treat tuberculosis is the phenotypic resistance adapted by the latent or dormant Mycobacterium tuberculosis (M. tuberculosis) cells against most of the available drugs. Different in-vitro assay such as oxygen depletion model and nutrient starvation models have contributed to unravelling the pathogen phenotypic resistance but are too cumbersome for application to high-throughput screening (HTS) assays. In this context, non-replicating streptomycin-starved 18b (SS18b) mutant strain of M. tuberculosis provided a simple and reproducible model. This model mimics latent tuberculosis and is best suited for screening medicinally appropriate libraries. Using SS18b strain in a resazurin reduction microplate assay (REMA), high-throughput screening of ChemDiv library constituting of 30,000 compounds resulted in the identification of 470 active compounds. Clustering and scaffolding based medicinal chemistry analysis characterized these hits into 15 scaffolds. Seven most potent compounds exhibiting an MIC ≤ 1 μg/ml against SS18b were non-toxic in HepG2 cell line (selective Index ≥ 160). Our screening revealed seven novel compounds exhibiting activity against the non-replicating form of M tuberculosis. 8002–7516 was the most promising compound showing intracellular killing and could be optimized to develop a lead drug candidate." @default.
• W3043546620 created "2020-07-23" @default.
• W3043546620 creator A5000099440 @default.
• W3043546620 creator A5000589552 @default.
• W3043546620 creator A5012791508 @default.
• W3043546620 creator A5038583677 @default.
• W3043546620 creator A5059953583 @default.
• W3043546620 creator A5064010187 @default.
• W3043546620 creator A5087809679 @default.
• W3043546620 creator A5091609772 @default.
• W3043546620 date "2020-09-01" @default.
• W3043546620 modified "2023-09-23" @default.
• W3043546620 title "High-throughput screening of compounds library to identify novel inhibitors against latent Mycobacterium tuberculosis using streptomycin-dependent Mycobacterium tuberculosis 18b strain as a model" @default.
• W3043546620 cites W1973789730 @default.
• W3043546620 cites W1974234256 @default.
• W3043546620 cites W1982498335 @default.
• W3043546620 cites W1990587033 @default.
• W3043546620 cites W1991641043 @default.
• W3043546620 cites W2018241485 @default.
• W3043546620 cites W2019835759 @default.
• W3043546620 cites W2022452916 @default.
• W3043546620 cites W2042321138 @default.
• W3043546620 cites W2056108991 @default.
• W3043546620 cites W2064956914 @default.
• W3043546620 cites W2078663039 @default.
• W3043546620 cites W2115925761 @default.
• W3043546620 cites W2122230617 @default.
• W3043546620 cites W2123084649 @default.
• W3043546620 cites W2125112523 @default.
• W3043546620 cites W2125404477 @default.
• W3043546620 cites W2131731929 @default.
• W3043546620 cites W2137088409 @default.
• W3043546620 cites W2137619594 @default.
• W3043546620 cites W2139012536 @default.
• W3043546620 cites W2167588734 @default.
• W3043546620 cites W2170377094 @default.
• W3043546620 cites W2320215152 @default.
• W3043546620 cites W2330792613 @default.
• W3043546620 cites W2418210342 @default.
• W3043546620 cites W2953525123 @default.
• W3043546620 doi "https://doi.org/10.1016/j.tube.2020.101958" @default.
• W3043546620 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32791471" @default.
• W3043546620 hasPublicationYear "2020" @default.
• W3043546620 type Work @default.
• W3043546620 sameAs 3043546620 @default.
• W3043546620 citedByCount "4" @default.
• W3043546620 countsByYear W30435466202022 @default.
• W3043546620 countsByYear W30435466202023 @default.
• W3043546620 crossrefType "journal-article" @default.
• W3043546620 hasAuthorship W3043546620A5000099440 @default.
• W3043546620 hasAuthorship W3043546620A5000589552 @default.
• W3043546620 hasAuthorship W3043546620A5012791508 @default.
• W3043546620 hasAuthorship W3043546620A5038583677 @default.
• W3043546620 hasAuthorship W3043546620A5059953583 @default.
• W3043546620 hasAuthorship W3043546620A5064010187 @default.
• W3043546620 hasAuthorship W3043546620A5087809679 @default.
• W3043546620 hasAuthorship W3043546620A5091609772 @default.
• W3043546620 hasConcept C114851261 @default.
• W3043546620 hasConcept C142724271 @default.
• W3043546620 hasConcept C151730666 @default.
• W3043546620 hasConcept C161624437 @default.
• W3043546620 hasConcept C185592680 @default.
• W3043546620 hasConcept C2775843808 @default.
• W3043546620 hasConcept C2777975735 @default.
• W3043546620 hasConcept C2778400546 @default.
• W3043546620 hasConcept C2779057010 @default.
• W3043546620 hasConcept C2779343474 @default.
• W3043546620 hasConcept C2780374374 @default.
• W3043546620 hasConcept C2781069245 @default.
• W3043546620 hasConcept C501593827 @default.
• W3043546620 hasConcept C51323132 @default.
• W3043546620 hasConcept C55493867 @default.
• W3043546620 hasConcept C71924100 @default.
• W3043546620 hasConcept C86803240 @default.
• W3043546620 hasConcept C89423630 @default.
• W3043546620 hasConceptScore W3043546620C114851261 @default.
• W3043546620 hasConceptScore W3043546620C142724271 @default.
• W3043546620 hasConceptScore W3043546620C151730666 @default.
• W3043546620 hasConceptScore W3043546620C161624437 @default.
• W3043546620 hasConceptScore W3043546620C185592680 @default.
• W3043546620 hasConceptScore W3043546620C2775843808 @default.
• W3043546620 hasConceptScore W3043546620C2777975735 @default.
• W3043546620 hasConceptScore W3043546620C2778400546 @default.
• W3043546620 hasConceptScore W3043546620C2779057010 @default.
• W3043546620 hasConceptScore W3043546620C2779343474 @default.
• W3043546620 hasConceptScore W3043546620C2780374374 @default.
• W3043546620 hasConceptScore W3043546620C2781069245 @default.
• W3043546620 hasConceptScore W3043546620C501593827 @default.
• W3043546620 hasConceptScore W3043546620C51323132 @default.
• W3043546620 hasConceptScore W3043546620C55493867 @default.
• W3043546620 hasConceptScore W3043546620C71924100 @default.
• W3043546620 hasConceptScore W3043546620C86803240 @default.
• W3043546620 hasConceptScore W3043546620C89423630 @default.
• W3043546620 hasFunder F4320320721 @default.
• W3043546620 hasLocation W30435466201 @default.
• W3043546620 hasOpenAccess W3043546620 @default.
• W3043546620 hasPrimaryLocation W30435466201 @default.
• W3043546620 hasRelatedWork W1963697099 @default.

• next