FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3043558730> ?p ?o ?g. }

• W3043558730 abstract "Human umbilical cord mesenchymal stem cells (hUC-MSCs) are a promising alternative source of mesenchymal stem cells (MSCs) that are enormously attractive for clinical use. This study was designed to investigate the effect of recombinant human bone morphogenetic protein-7 (rhBMP-7) and/or osteogenic media (OMD) on bone regeneration of hUC-MSCs seeded on nanohydroxyapatite/collagen/poly(l-lactide) (nHAC/PLA) in a rabbit model. The characteristics of stem cells were analyzed by plastic adherence, cell phenotype, and multilineage differentiation potential. Cell proliferation was examined using cell counting kit-8 assay. Osteogenic differentiation was evaluated by quantitative Ca2+ concentration, PO43- concentration, alkaline phosphatase (ALP) activity, osteocalcin (OCN) secretion, and mineralized matrix formation. Bone regeneration was investigated in jaw bone defect repair in rabbit by microcomputed tomography, fluorescent labeling, and hematoxylin and eosin staining. Except for initial stress response, OMD and OMD + rhBMP-7 inhibited the proliferation of hUC-MSCs seeded on nHAC/PLA; rhBMP-7 inhibited cell proliferation in the nonlogarithmic phase and attenuated the inhibitory effect of OMD on cell proliferation. The inhibitory effects of OMD, rhBMP-7, and OMD + rhBMP-7 on cell proliferation were ranked as OMD > OMD + rhBMP-7 > rhBMP-7. OMD, rhBMP-7, and OMD + rhBMP-7 promoted Ca2+ concentration, PO43- concentration, ALP activity, OCN secretion, and mineralized matrix formation of hUC-MSCs seeded on nHAC/PLA. The promoting effects of OMD, rhBMP-7, and OMD+rhBMP-7 on Ca2+ concentration, PO43- concentration, ALP activity, OCN secretion, and mineralized matrix formation were ranked as rhBMP-7 > OMD > OMD + rhBMP-7, OMD > OMD + rhBMP-7 > rhBMP-7, OMD > rhBMP-7 > OMD + rhBMP-7, rhBMP-7 > OMD + rhBMP-7 > OMD, and OMD > rhBMP-7 > OMD + rhBMP-7, respectively. In rabbit jaw bone defect repair, OMD, rhBMP-7, and OMD + rhBMP-7 enhanced bone regeneration of hUC-MSCs seeded on nHAC/PLA, but the largest bone mineral apposition rate and bone formation were presented in cultures with rhBMP-7. These findings suggested that the combined use of rhBMP-7 and OMD may have no ideal synergistic effect on bone regeneration of hUC-MSCs seeded on nHAC/PLA in rabbit jaw bone defect." @default.
• W3043558730 created "2020-07-23" @default.
• W3043558730 creator A5014235931 @default.
• W3043558730 creator A5025256775 @default.
• W3043558730 creator A5029051738 @default.
• W3043558730 creator A5029131284 @default.
• W3043558730 creator A5051586443 @default.
• W3043558730 creator A5082924617 @default.
• W3043558730 creator A5083967189 @default.
• W3043558730 date "2020-09-15" @default.
• W3043558730 modified "2023-10-02" @default.
• W3043558730 title "Combined Use of Recombinant Human BMP-7 and Osteogenic Media May Have No Ideal Synergistic Effect on Leporine Bone Regeneration of Human Umbilical Cord Mesenchymal Stem Cells Seeded on Nanohydroxyapatite/Collagen/Poly (l-Lactide)" @default.
• W3043558730 cites W1541198903 @default.
• W3043558730 cites W1589183360 @default.
• W3043558730 cites W1916587464 @default.
• W3043558730 cites W1968286356 @default.
• W3043558730 cites W1969644104 @default.
• W3043558730 cites W1972784319 @default.
• W3043558730 cites W1973689937 @default.
• W3043558730 cites W1975520535 @default.
• W3043558730 cites W1984833486 @default.
• W3043558730 cites W2001540095 @default.
• W3043558730 cites W2011467182 @default.
• W3043558730 cites W2016471778 @default.
• W3043558730 cites W2019893470 @default.
• W3043558730 cites W2022390680 @default.
• W3043558730 cites W2033288777 @default.
• W3043558730 cites W2033524865 @default.
• W3043558730 cites W2034402660 @default.
• W3043558730 cites W2037134742 @default.
• W3043558730 cites W2049826432 @default.
• W3043558730 cites W2057126195 @default.
• W3043558730 cites W2058002158 @default.
• W3043558730 cites W2061807932 @default.
• W3043558730 cites W2071692347 @default.
• W3043558730 cites W2083393512 @default.
• W3043558730 cites W2087596556 @default.
• W3043558730 cites W2088398635 @default.
• W3043558730 cites W2092317909 @default.
• W3043558730 cites W2093435754 @default.
• W3043558730 cites W2097767628 @default.
• W3043558730 cites W2098381715 @default.
• W3043558730 cites W2112699535 @default.
• W3043558730 cites W2121737169 @default.
• W3043558730 cites W2125508795 @default.
• W3043558730 cites W2128382826 @default.
• W3043558730 cites W2141488316 @default.
• W3043558730 cites W2148064846 @default.
• W3043558730 cites W2163780400 @default.
• W3043558730 cites W2501238676 @default.
• W3043558730 cites W2508206631 @default.
• W3043558730 cites W2516964868 @default.
• W3043558730 cites W2622741333 @default.
• W3043558730 cites W2900178157 @default.
• W3043558730 cites W2949838516 @default.
• W3043558730 cites W2957989341 @default.
• W3043558730 cites W2990901926 @default.
• W3043558730 cites W2994818400 @default.
• W3043558730 cites W2996470667 @default.
• W3043558730 cites W2999455045 @default.
• W3043558730 cites W2993184704 @default.
• W3043558730 doi "https://doi.org/10.1089/scd.2020.0066" @default.
• W3043558730 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32674666" @default.
• W3043558730 hasPublicationYear "2020" @default.
• W3043558730 type Work @default.
• W3043558730 sameAs 3043558730 @default.
• W3043558730 citedByCount "2" @default.
• W3043558730 countsByYear W30435587302021 @default.
• W3043558730 crossrefType "journal-article" @default.
• W3043558730 hasAuthorship W3043558730A5014235931 @default.
• W3043558730 hasAuthorship W3043558730A5025256775 @default.
• W3043558730 hasAuthorship W3043558730A5029051738 @default.
• W3043558730 hasAuthorship W3043558730A5029131284 @default.
• W3043558730 hasAuthorship W3043558730A5051586443 @default.
• W3043558730 hasAuthorship W3043558730A5082924617 @default.
• W3043558730 hasAuthorship W3043558730A5083967189 @default.
• W3043558730 hasConcept C131075544 @default.
• W3043558730 hasConcept C160160445 @default.
• W3043558730 hasConcept C181199279 @default.
• W3043558730 hasConcept C185592680 @default.
• W3043558730 hasConcept C198826908 @default.
• W3043558730 hasConcept C202751555 @default.
• W3043558730 hasConcept C28328180 @default.
• W3043558730 hasConcept C30352789 @default.
• W3043558730 hasConcept C55493867 @default.
• W3043558730 hasConcept C86803240 @default.
• W3043558730 hasConcept C95444343 @default.
• W3043558730 hasConceptScore W3043558730C131075544 @default.
• W3043558730 hasConceptScore W3043558730C160160445 @default.
• W3043558730 hasConceptScore W3043558730C181199279 @default.
• W3043558730 hasConceptScore W3043558730C185592680 @default.
• W3043558730 hasConceptScore W3043558730C198826908 @default.
• W3043558730 hasConceptScore W3043558730C202751555 @default.
• W3043558730 hasConceptScore W3043558730C28328180 @default.
• W3043558730 hasConceptScore W3043558730C30352789 @default.
• W3043558730 hasConceptScore W3043558730C55493867 @default.
• W3043558730 hasConceptScore W3043558730C86803240 @default.
• W3043558730 hasConceptScore W3043558730C95444343 @default.
• W3043558730 hasLocation W30435587301 @default.
• W3043558730 hasOpenAccess W3043558730 @default.

• next