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• W3043644916 endingPage "111006" @default.
• W3043644916 startingPage "111006" @default.
• W3043644916 abstract "Nickel (Ni) is a widely distributed metal in the environment and an important pollutant because of its many industrial applications. With increasing incidences of Ni contamination, Ni toxicity has become a global public health concern and recent evidence suggests that Ni adversely affects the immune system. Hence, this paper reviews the literature on immune-related effects of Ni exposure, the immunotoxicological effects of Ni, and the underlying mechanism of Ni immunotoxicity. The main focus was on the effect of Ni on the development of organs of immune system, lymphocyte subpopulations, cytokines, immunoglobulins, natural killer (NK) cells, and macrophages. Moreover, Ni toxicity also induces inflammation and several studies demonstrated that Ni could induce immunotoxicity. Excessive Ni exposure can inhibit the development of immune organs by excessively inducing apoptosis and inhibiting proliferation. Furthermore, Ni can decrease T and B lymphocytes, the specific mechanism of which requires further research. The effects of Ni on immunoglobulin A (IgA), IgG, and IgM remain unknown and while Ni inhibited IgA, IgG, and IgM levels in an animal experiment, the opposite result was found in research on humans. Ni inhibits the production of cytokines in non-inflammatory responses. Cytokine levels increased in Ni-induced inflammation responses, and Ni activates inflammation through toll like (TL)4-mediated nuclear factor-κB (NF-κB) and signal transduction cascades mitogen-activated protein kinase (MAPK) pathways. Ni has been indicated to inactivate NK cells and macrophages both in vitro and in vivo. Identifying the mechanisms underlying the Ni-induced immunotoxicity may help to explain the growing risk of infections and cancers in human populations that have been exposed to Ni for a long time. Such knowledge may also help to prevent and treat Ni-related carcinogenicity and toxicology." @default.
• W3043644916 created "2020-07-23" @default.
• W3043644916 creator A5009912208 @default.
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• W3043644916 creator A5079878898 @default.
• W3043644916 creator A5089684709 @default.
• W3043644916 creator A5090346341 @default.
• W3043644916 date "2020-10-01" @default.
• W3043644916 modified "2023-10-06" @default.
• W3043644916 title "Immunotoxicity of nickel: Pathological and toxicological effects" @default.
• W3043644916 cites W1486030939 @default.
• W3043644916 cites W1504167407 @default.
• W3043644916 cites W1520274095 @default.
• W3043644916 cites W1531966778 @default.
• W3043644916 cites W1639742563 @default.
• W3043644916 cites W171793030 @default.
• W3043644916 cites W1755157858 @default.
• W3043644916 cites W1842143307 @default.
• W3043644916 cites W1966047059 @default.
• W3043644916 cites W1971304356 @default.
• W3043644916 cites W1974482497 @default.
• W3043644916 cites W1976679328 @default.
• W3043644916 cites W1976858426 @default.
• W3043644916 cites W1977949015 @default.
• W3043644916 cites W1978933734 @default.
• W3043644916 cites W1979314182 @default.
• W3043644916 cites W1988182648 @default.
• W3043644916 cites W1991672137 @default.
• W3043644916 cites W1992494324 @default.
• W3043644916 cites W1994632188 @default.
• W3043644916 cites W2002092761 @default.
• W3043644916 cites W2005593410 @default.
• W3043644916 cites W2007041426 @default.
• W3043644916 cites W2009041249 @default.
• W3043644916 cites W2012193708 @default.
• W3043644916 cites W2012930967 @default.
• W3043644916 cites W2013053627 @default.
• W3043644916 cites W2025961635 @default.
• W3043644916 cites W2029666631 @default.
• W3043644916 cites W2031834135 @default.
• W3043644916 cites W2038689279 @default.
• W3043644916 cites W2040083917 @default.
• W3043644916 cites W2041891547 @default.
• W3043644916 cites W2050806482 @default.
• W3043644916 cites W2052562021 @default.
• W3043644916 cites W2057254743 @default.
• W3043644916 cites W2057320783 @default.
• W3043644916 cites W2058689492 @default.
• W3043644916 cites W2061098044 @default.
• W3043644916 cites W2068254782 @default.
• W3043644916 cites W2071065215 @default.
• W3043644916 cites W2071107998 @default.
• W3043644916 cites W2073033425 @default.
• W3043644916 cites W2073300038 @default.
• W3043644916 cites W2078448758 @default.
• W3043644916 cites W2081814313 @default.
• W3043644916 cites W2084401256 @default.
• W3043644916 cites W2085704361 @default.
• W3043644916 cites W2087262028 @default.
• W3043644916 cites W2088463568 @default.
• W3043644916 cites W2095047900 @default.
• W3043644916 cites W2114269157 @default.
• W3043644916 cites W2118772872 @default.
• W3043644916 cites W2121887582 @default.
• W3043644916 cites W2128148261 @default.
• W3043644916 cites W2129096581 @default.
• W3043644916 cites W2131229688 @default.
• W3043644916 cites W2133770419 @default.
• W3043644916 cites W2134414426 @default.
• W3043644916 cites W2138166405 @default.
• W3043644916 cites W2145407859 @default.
• W3043644916 cites W2148125367 @default.
• W3043644916 cites W2149903494 @default.
• W3043644916 cites W2171958257 @default.
• W3043644916 cites W2211302656 @default.
• W3043644916 cites W2258912243 @default.
• W3043644916 cites W2260036769 @default.
• W3043644916 cites W2299917979 @default.
• W3043644916 cites W2469163477 @default.
• W3043644916 cites W2486503639 @default.
• W3043644916 cites W2494923240 @default.
• W3043644916 cites W2518685332 @default.
• W3043644916 cites W2520866824 @default.
• W3043644916 cites W2542496000 @default.
• W3043644916 cites W2552852593 @default.
• W3043644916 cites W2557893886 @default.
• W3043644916 cites W2560758606 @default.
• W3043644916 cites W2625950214 @default.
• W3043644916 cites W2696164464 @default.
• W3043644916 cites W2739826847 @default.
• W3043644916 cites W2762588598 @default.

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