Matches in SemOpenAlex for { <https://semopenalex.org/work/W3043658705> ?p ?o ?g. }
- W3043658705 abstract "Diabetes mellitus (DM) and Parkinson's disease (PD) have been and will continue to be two common chronic diseases globally that are difficult to diagnose during the prodromal phase. Current molecular genetics, cell biological, and epidemiological evidences have shown the correlation between PD and DM. PD shares the same pathogenesis pathways and pathological factors with DM. In addition, β-cell reduction, which can cause hyperglycemia, is a striking feature of DM. Recent studies indicated that hyperglycemia is highly relevant to the pathologic changes in PD. However, further correlation between DM and PD remains to be investigated. Intriguingly, polycystic monoamine transporter 2 (VMAT2), which is co-expressed in dopaminergic neurons and β cells, is responsible for taking up dopamine into the presynaptic vesicles and can specifically bind to the β cells. Furthermore, we have summarized the specific molecular and diagnostic functions of VMAT2 for the two diseases reported in this review. Therefore, VMAT2 can be applied as a target probe for positron emission tomography (PET) imaging to detect β-cell and dopamine level changes, which can contribute to the diagnosis of DM and PD during the prodromal phase. Targeting VMAT2 with the molecular probe 18F-FP-(+)-DTBZ can be an entry point for the β cell mass (BCM) changes in DM at the molecular level, to clarify the potential relationship between DM and PD. VMAT2 has promising clinical significance in investigating the pathogenesis, early diagnosis, and treatment evaluation of the two diseases." @default.
- W3043658705 created "2020-07-23" @default.
- W3043658705 creator A5008771137 @default.
- W3043658705 creator A5030147577 @default.
- W3043658705 creator A5036013509 @default.
- W3043658705 creator A5043330039 @default.
- W3043658705 creator A5062879273 @default.
- W3043658705 creator A5068116893 @default.
- W3043658705 creator A5068853308 @default.
- W3043658705 creator A5069296565 @default.
- W3043658705 creator A5081384338 @default.
- W3043658705 date "2020-07-14" @default.
- W3043658705 modified "2023-10-06" @default.
- W3043658705 title "Elucidating the Relationship Between Diabetes Mellitus and Parkinson’s Disease Using 18F-FP-(+)-DTBZ, a Positron-Emission Tomography Probe for Vesicular Monoamine Transporter 2" @default.
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