FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3043662389> ?p ?o ?g. }

• W3043662389 endingPage "824" @default.
• W3043662389 startingPage "814" @default.
• W3043662389 abstract "Among 15 nonstructural proteins (Nsps), the newly emerging Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) encodes a large, multidomain Nsp3. One of its units is the ADP-ribose phosphatase domain (ADRP; also known as the macrodomain, MacroD), which is believed to interfere with the host immune response. Such a function appears to be linked to the ability of the protein to remove ADP-ribose from ADP-ribosylated proteins and RNA, yet the precise role and molecular targets of the enzyme remain unknown. Here, five high-resolution (1.07-2.01 Å) crystal structures corresponding to the apo form of the protein and its complexes with 2-(N-morpholino)ethanesulfonic acid (MES), AMP and ADP-ribose have been determined. The protein is shown to undergo conformational changes to adapt to the ligand in the manner previously observed in close homologues from other viruses. A conserved water molecule is also identified that may participate in hydrolysis. This work builds foundations for future structure-based research on ADRP, including the search for potential antiviral therapeutics." @default.
• W3043662389 created "2020-07-23" @default.
• W3043662389 creator A5015893701 @default.
• W3043662389 creator A5029029783 @default.
• W3043662389 creator A5030976943 @default.
• W3043662389 creator A5053702486 @default.
• W3043662389 creator A5055128033 @default.
• W3043662389 creator A5067090355 @default.
• W3043662389 creator A5075078265 @default.
• W3043662389 date "2020-07-17" @default.
• W3043662389 modified "2023-10-17" @default.
• W3043662389 title "Crystal structures of SARS-CoV-2 ADP-ribose phosphatase: from the apo form to ligand complexes" @default.
• W3043662389 cites W1487052430 @default.
• W3043662389 cites W1973820404 @default.
• W3043662389 cites W1982285205 @default.
• W3043662389 cites W1986191025 @default.
• W3043662389 cites W1996259826 @default.
• W3043662389 cites W1996423252 @default.
• W3043662389 cites W2000843938 @default.
• W3043662389 cites W2019184993 @default.
• W3043662389 cites W2025525406 @default.
• W3043662389 cites W2028729402 @default.
• W3043662389 cites W2030517878 @default.
• W3043662389 cites W2056022472 @default.
• W3043662389 cites W2085122038 @default.
• W3043662389 cites W2087363345 @default.
• W3043662389 cites W2103503400 @default.
• W3043662389 cites W2108145534 @default.
• W3043662389 cites W2108921801 @default.
• W3043662389 cites W2108959691 @default.
• W3043662389 cites W2122109248 @default.
• W3043662389 cites W2124026197 @default.
• W3043662389 cites W2133706960 @default.
• W3043662389 cites W2146080841 @default.
• W3043662389 cites W2154714625 @default.
• W3043662389 cites W2157509471 @default.
• W3043662389 cites W2159211495 @default.
• W3043662389 cites W2162697017 @default.
• W3043662389 cites W2163279093 @default.
• W3043662389 cites W2170370930 @default.
• W3043662389 cites W2171291163 @default.
• W3043662389 cites W2217204947 @default.
• W3043662389 cites W2232780020 @default.
• W3043662389 cites W2325521056 @default.
• W3043662389 cites W2394710035 @default.
• W3043662389 cites W2415408105 @default.
• W3043662389 cites W2503176400 @default.
• W3043662389 cites W2519928122 @default.
• W3043662389 cites W2584528688 @default.
• W3043662389 cites W2766471599 @default.
• W3043662389 cites W2768064447 @default.
• W3043662389 cites W2903899730 @default.
• W3043662389 cites W2944980314 @default.
• W3043662389 cites W2949222247 @default.
• W3043662389 cites W2973457155 @default.
• W3043662389 cites W3003217347 @default.
• W3043662389 cites W3004047749 @default.
• W3043662389 cites W3009906937 @default.
• W3043662389 cites W3021526350 @default.
• W3043662389 cites W3026872319 @default.
• W3043662389 cites W3034593359 @default.
• W3043662389 cites W3036482641 @default.
• W3043662389 cites W3041333867 @default.
• W3043662389 cites W4210539972 @default.
• W3043662389 doi "https://doi.org/10.1107/s2052252520009653" @default.
• W3043662389 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7467174" @default.
• W3043662389 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32939273" @default.
• W3043662389 hasPublicationYear "2020" @default.
• W3043662389 type Work @default.
• W3043662389 sameAs 3043662389 @default.
• W3043662389 citedByCount "81" @default.
• W3043662389 countsByYear W30436623892020 @default.
• W3043662389 countsByYear W30436623892021 @default.
• W3043662389 countsByYear W30436623892022 @default.
• W3043662389 countsByYear W30436623892023 @default.
• W3043662389 crossrefType "journal-article" @default.
• W3043662389 hasAuthorship W3043662389A5015893701 @default.
• W3043662389 hasAuthorship W3043662389A5029029783 @default.
• W3043662389 hasAuthorship W3043662389A5030976943 @default.
• W3043662389 hasAuthorship W3043662389A5053702486 @default.
• W3043662389 hasAuthorship W3043662389A5055128033 @default.
• W3043662389 hasAuthorship W3043662389A5067090355 @default.
• W3043662389 hasAuthorship W3043662389A5075078265 @default.
• W3043662389 hasBestOaLocation W30436623891 @default.
• W3043662389 hasConcept C104317684 @default.
• W3043662389 hasConcept C116569031 @default.
• W3043662389 hasConcept C170493617 @default.
• W3043662389 hasConcept C178666793 @default.
• W3043662389 hasConcept C181199279 @default.
• W3043662389 hasConcept C185592680 @default.
• W3043662389 hasConcept C2779461342 @default.
• W3043662389 hasConcept C2780120296 @default.
• W3043662389 hasConcept C47701112 @default.
• W3043662389 hasConcept C55493867 @default.
• W3043662389 hasConcept C67705224 @default.
• W3043662389 hasConcept C86803240 @default.
• W3043662389 hasConceptScore W3043662389C104317684 @default.
• W3043662389 hasConceptScore W3043662389C116569031 @default.

• next