FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3043746395> ?p ?o ?g. }

• W3043746395 abstract "Neuropathic pain is a chronic condition that remains a major clinical problem due to high resistance to available therapy. Recent studies have indicated that chemokine signaling pathways are crucial in the development of painful neuropathy; however, the involvement of CC chemokine receptor 4 (CCR4) has not been fully elucidated thus far. Therefore, the aim of our research was to investigate the role of CCR4 in the development of tactile and thermal hypersensitivity, the effectiveness of morphine/buprenorphine and opioid-induced tolerance in mice exposed to chronic constriction injury (CCI) of the sciatic nerve. The results of our research demonstrated that a single intrathecal or intraperitoneal administration of C021, a CCR4 antagonist, dose-dependently diminished neuropathic pain-related behaviors in CCI-exposed mice. After sciatic nerve injury, the spinal expression of CCL17 and CCL22 remained unchanged in contrast to that of CCL2, which was significantly upregulated until day 14 after CCI. Importantly, our results provide evidence that in naive mice, CCL2 may evoke pain-related behaviors through CCR4 since its pronociceptive effects are diminished by C021. In CCI-exposed mice, the pharmacological blockade of CCR4 enhanced the analgesic properties of morphine/buprenorphine and delayed the development of morphine-induced tolerance, which was associated with the silencing of IBA-1 activation in cells and decreases in CCL2 production. The obtained data suggest that the pharmacological blockade of CCR4 may be a new potential therapeutic target for neuropathic pain polytherapy." @default.
• W3043746395 created "2020-07-23" @default.
• W3043746395 creator A5003101597 @default.
• W3043746395 creator A5010370127 @default.
• W3043746395 creator A5029861602 @default.
• W3043746395 creator A5034168138 @default.
• W3043746395 creator A5043416408 @default.
• W3043746395 creator A5061433194 @default.
• W3043746395 creator A5084767098 @default.
• W3043746395 date "2020-07-14" @default.
• W3043746395 modified "2023-10-17" @default.
• W3043746395 title "CCR4 Antagonist (C021) Administration Diminishes Hypersensitivity and Enhances the Analgesic Potency of Morphine and Buprenorphine in a Mouse Model of Neuropathic Pain" @default.
• W3043746395 cites W1492276622 @default.
• W3043746395 cites W1540570460 @default.
• W3043746395 cites W1560719607 @default.
• W3043746395 cites W1661652663 @default.
• W3043746395 cites W1968259371 @default.
• W3043746395 cites W1973249845 @default.
• W3043746395 cites W1980660681 @default.
• W3043746395 cites W1985178609 @default.
• W3043746395 cites W1986991315 @default.
• W3043746395 cites W1992389336 @default.
• W3043746395 cites W1993285878 @default.
• W3043746395 cites W1995471440 @default.
• W3043746395 cites W1996183419 @default.
• W3043746395 cites W2008628750 @default.
• W3043746395 cites W2009466572 @default.
• W3043746395 cites W2009569010 @default.
• W3043746395 cites W2012974254 @default.
• W3043746395 cites W2013145726 @default.
• W3043746395 cites W2016052090 @default.
• W3043746395 cites W2016315625 @default.
• W3043746395 cites W2021440104 @default.
• W3043746395 cites W2025878623 @default.
• W3043746395 cites W2026881175 @default.
• W3043746395 cites W2028762442 @default.
• W3043746395 cites W2030194369 @default.
• W3043746395 cites W2030437338 @default.
• W3043746395 cites W2039563461 @default.
• W3043746395 cites W2041008164 @default.
• W3043746395 cites W2046208657 @default.
• W3043746395 cites W2058020736 @default.
• W3043746395 cites W2062728888 @default.
• W3043746395 cites W2063733108 @default.
• W3043746395 cites W2067438849 @default.
• W3043746395 cites W2073809111 @default.
• W3043746395 cites W2082534109 @default.
• W3043746395 cites W2083088604 @default.
• W3043746395 cites W2083519153 @default.
• W3043746395 cites W2086990722 @default.
• W3043746395 cites W2087439428 @default.
• W3043746395 cites W2087454739 @default.
• W3043746395 cites W2090804892 @default.
• W3043746395 cites W2092460680 @default.
• W3043746395 cites W2094880231 @default.
• W3043746395 cites W2124355299 @default.
• W3043746395 cites W2124673849 @default.
• W3043746395 cites W2129741568 @default.
• W3043746395 cites W2136588877 @default.
• W3043746395 cites W2144414931 @default.
• W3043746395 cites W2160882555 @default.
• W3043746395 cites W2165145815 @default.
• W3043746395 cites W2165936803 @default.
• W3043746395 cites W2170225187 @default.
• W3043746395 cites W2205880602 @default.
• W3043746395 cites W2230694838 @default.
• W3043746395 cites W2329566403 @default.
• W3043746395 cites W2346028978 @default.
• W3043746395 cites W2532219885 @default.
• W3043746395 cites W2599989119 @default.
• W3043746395 cites W2640341220 @default.
• W3043746395 cites W2728534417 @default.
• W3043746395 cites W2734804244 @default.
• W3043746395 cites W2765390900 @default.
• W3043746395 cites W2787993416 @default.
• W3043746395 cites W2789861154 @default.
• W3043746395 cites W2800063347 @default.
• W3043746395 cites W2800573721 @default.
• W3043746395 cites W2804550352 @default.
• W3043746395 cites W2890847880 @default.
• W3043746395 cites W2904185271 @default.
• W3043746395 cites W2923081322 @default.
• W3043746395 cites W2936852271 @default.
• W3043746395 cites W2999573855 @default.
• W3043746395 cites W3001935109 @default.
• W3043746395 cites W3025703531 @default.
• W3043746395 cites W4211119836 @default.
• W3043746395 cites W4240857734 @default.
• W3043746395 cites W578302238 @default.
• W3043746395 doi "https://doi.org/10.3389/fimmu.2020.01241" @default.
• W3043746395 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7372009" @default.
• W3043746395 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32760393" @default.
• W3043746395 hasPublicationYear "2020" @default.
• W3043746395 type Work @default.
• W3043746395 sameAs 3043746395 @default.
• W3043746395 citedByCount "16" @default.
• W3043746395 countsByYear W30437463952020 @default.
• W3043746395 countsByYear W30437463952021 @default.
• W3043746395 countsByYear W30437463952022 @default.
• W3043746395 countsByYear W30437463952023 @default.

• next