FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3043757673> ?p ?o ?g. }

• W3043757673 abstract "Abstract Microfibril-associated glycoprotein 4 (MFAP4) is an extracellular matrix protein belonging to the fibrinogen-related protein superfamily. MFAP4 is produced by vascular smooth muscle cells and is highly enriched in the blood vessels of the heart and lung, where it is thought to contribute to the structure and function of elastic fibers. Genetic studies in humans have implicated MFAP4 in the pathogenesis of Smith-Magenis syndrome, in which patients present with multiple congenital abnormalities and mental retardation, as well as in the severe cardiac malformation left-sided congenital heart disease. Comprehensive genetic analysis of the role of MFAP4 orthologues in model organisms during development and tissue homeostasis is however lacking. Here, we demonstrate that zebrafish mfap4 transcripts are detected embryonically, resolving to the macrophage lineage by 24 h post fertilization. mfap4 null mutant zebrafish are unexpectedly viable and fertile, without ostensible phenotypes. However, tail fin amputation assays reveal that mfap4 mutants have reduced numbers of macrophages, with a concomitant increase in neutrophilic granulocytes, although recruitment of both cell types to the site of injury was unaffected. Molecular analyses suggest that loss of Mfap4 alters the balance between myeloid and lymphoid lineages during both primitive and definitive haematopoiesis, which could significantly impact the downstream function of the immune system." @default.
• W3043757673 created "2020-07-23" @default.
• W3043757673 creator A5005244747 @default.
• W3043757673 creator A5025117081 @default.
• W3043757673 creator A5027236889 @default.
• W3043757673 creator A5078042017 @default.
• W3043757673 creator A5083778886 @default.
• W3043757673 date "2020-07-16" @default.
• W3043757673 modified "2023-10-17" @default.
• W3043757673 title "Microfibril-associated glycoprotein 4 (Mfap4) regulates haematopoiesis in zebrafish" @default.
• W3043757673 cites W1529988378 @default.
• W3043757673 cites W1597339764 @default.
• W3043757673 cites W1609952567 @default.
• W3043757673 cites W1881356795 @default.
• W3043757673 cites W1910850152 @default.
• W3043757673 cites W1969098700 @default.
• W3043757673 cites W1971398219 @default.
• W3043757673 cites W1977743262 @default.
• W3043757673 cites W1980353886 @default.
• W3043757673 cites W1999353776 @default.
• W3043757673 cites W2001229583 @default.
• W3043757673 cites W2004798786 @default.
• W3043757673 cites W2007260996 @default.
• W3043757673 cites W2009110567 @default.
• W3043757673 cites W2014896262 @default.
• W3043757673 cites W2024575580 @default.
• W3043757673 cites W2024707653 @default.
• W3043757673 cites W2025589527 @default.
• W3043757673 cites W2026028836 @default.
• W3043757673 cites W2027703497 @default.
• W3043757673 cites W2028543411 @default.
• W3043757673 cites W2030017298 @default.
• W3043757673 cites W2033766516 @default.
• W3043757673 cites W2035929027 @default.
• W3043757673 cites W2036233315 @default.
• W3043757673 cites W2040080187 @default.
• W3043757673 cites W2042571711 @default.
• W3043757673 cites W2044046770 @default.
• W3043757673 cites W2050195517 @default.
• W3043757673 cites W2052207288 @default.
• W3043757673 cites W2053188090 @default.
• W3043757673 cites W2070111371 @default.
• W3043757673 cites W2074774606 @default.
• W3043757673 cites W2084080290 @default.
• W3043757673 cites W2084403389 @default.
• W3043757673 cites W2086828658 @default.
• W3043757673 cites W2100660634 @default.
• W3043757673 cites W2103957643 @default.
• W3043757673 cites W2104048810 @default.
• W3043757673 cites W2116514710 @default.
• W3043757673 cites W2117189371 @default.
• W3043757673 cites W2140733984 @default.
• W3043757673 cites W2148736733 @default.
• W3043757673 cites W2152663152 @default.
• W3043757673 cites W2154699417 @default.
• W3043757673 cites W2162210817 @default.
• W3043757673 cites W2163078748 @default.
• W3043757673 cites W2165459289 @default.
• W3043757673 cites W2167898988 @default.
• W3043757673 cites W2181242709 @default.
• W3043757673 cites W2184156621 @default.
• W3043757673 cites W2215102004 @default.
• W3043757673 cites W2414247940 @default.
• W3043757673 cites W2627053690 @default.
• W3043757673 cites W272428685 @default.
• W3043757673 cites W2735720719 @default.
• W3043757673 cites W2747398212 @default.
• W3043757673 cites W2769585090 @default.
• W3043757673 cites W2790969599 @default.
• W3043757673 cites W2884060324 @default.
• W3043757673 cites W2887670374 @default.
• W3043757673 cites W2910977678 @default.
• W3043757673 doi "https://doi.org/10.1038/s41598-020-68792-8" @default.
• W3043757673 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7366704" @default.
• W3043757673 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32678226" @default.
• W3043757673 hasPublicationYear "2020" @default.
• W3043757673 type Work @default.
• W3043757673 sameAs 3043757673 @default.
• W3043757673 citedByCount "13" @default.
• W3043757673 countsByYear W30437576732021 @default.
• W3043757673 countsByYear W30437576732022 @default.
• W3043757673 countsByYear W30437576732023 @default.
• W3043757673 crossrefType "journal-article" @default.
• W3043757673 hasAuthorship W3043757673A5005244747 @default.
• W3043757673 hasAuthorship W3043757673A5025117081 @default.
• W3043757673 hasAuthorship W3043757673A5027236889 @default.
• W3043757673 hasAuthorship W3043757673A5078042017 @default.
• W3043757673 hasAuthorship W3043757673A5083778886 @default.
• W3043757673 hasBestOaLocation W30437576731 @default.
• W3043757673 hasConcept C104317684 @default.
• W3043757673 hasConcept C108625454 @default.
• W3043757673 hasConcept C109159458 @default.
• W3043757673 hasConcept C127716648 @default.
• W3043757673 hasConcept C143065580 @default.
• W3043757673 hasConcept C189165786 @default.
• W3043757673 hasConcept C203014093 @default.
• W3043757673 hasConcept C2776878037 @default.
• W3043757673 hasConcept C2780942790 @default.
• W3043757673 hasConcept C28328180 @default.
• W3043757673 hasConcept C54355233 @default.

• next