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- W3043758472 endingPage "127678" @default.
- W3043758472 startingPage "127678" @default.
- W3043758472 abstract "The rise of cancer cases worldwide led to an increase in production and consumption of anticancer drugs, that ultimately end up in the marine environment and are accumulated in aquatic organisms. Cyclophosphamide (CP) is a cytotoxic alkylating agent frequently prescribed in cancer treatments. This study assess ecotoxicological effects of CP on mussels Mytilus galloprovincialis, through in vivo and ex vivo approaches and compares the sensitivity of mussel haemocytes with well-established human cell lines (RPE and HeLa). Mussels were exposed in vivo to CP (1000 ng L-1) and several biomarkers analysed in gills and digestive glands namely neurotoxicity (AChE activity), oxidative stress (GPx activity), biotransformation (GST activity), lipid peroxidation (LPO) and apoptosis (caspase activity), whereas genotoxicity was determined in mussels' haemocytes. Cytotoxicity was also assessed in haemocytes (in vivo and ex vivo) and human cell lines (in vitro) exposed to a range of CP concentrations (50, 100, 250, 500 and 1000 ng L-1) over 24 h, via neutral red assay. In in vivo exposure, detoxification of CP did not efficiently occur in the gills while in digestive glands GPx and GST activities were induced, jointly with a decrease in lipid peroxidation, indicating a potential outcome of the protective antioxidant mechanisms, whereas no apoptosis was noted. Moreover, cytotoxicity and DNA damage were detected in haemocytes. The ex vivo exposure haemocytes to CP caused cytotoxicity (from 100 ng L-1), whereas no effects occurred in human cell lines. This suggests that, at relevant environmental concentrations, CP cause subtle and irreversible impacts on M. galloprovincialis." @default.
- W3043758472 created "2020-07-23" @default.
- W3043758472 creator A5001117994 @default.
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- W3043758472 creator A5046717165 @default.
- W3043758472 creator A5076671935 @default.
- W3043758472 creator A5091029226 @default.
- W3043758472 date "2020-12-01" @default.
- W3043758472 modified "2023-10-17" @default.
- W3043758472 title "Cytotoxic responses of the anticancer drug cyclophosphamide in the mussel Mytilus galloprovincialis and comparative sensitivity with human cells lines" @default.
- W3043758472 cites W152205938 @default.
- W3043758472 cites W1546060975 @default.
- W3043758472 cites W1581414347 @default.
- W3043758472 cites W1757407923 @default.
- W3043758472 cites W1964066906 @default.
- W3043758472 cites W1964855873 @default.
- W3043758472 cites W1967174720 @default.
- W3043758472 cites W1967730770 @default.
- W3043758472 cites W1968325292 @default.
- W3043758472 cites W1969524738 @default.
- W3043758472 cites W1969571373 @default.
- W3043758472 cites W1971048984 @default.
- W3043758472 cites W1975800000 @default.
- W3043758472 cites W1975980695 @default.
- W3043758472 cites W1979708343 @default.
- W3043758472 cites W1980835283 @default.
- W3043758472 cites W1985169243 @default.
- W3043758472 cites W1986027940 @default.
- W3043758472 cites W1986269821 @default.
- W3043758472 cites W1991393820 @default.
- W3043758472 cites W1991657490 @default.
- W3043758472 cites W1992399868 @default.
- W3043758472 cites W1995192043 @default.
- W3043758472 cites W1998794592 @default.
- W3043758472 cites W2004045114 @default.
- W3043758472 cites W2008361485 @default.
- W3043758472 cites W2008694179 @default.
- W3043758472 cites W2011000150 @default.
- W3043758472 cites W2011842176 @default.
- W3043758472 cites W2016046606 @default.
- W3043758472 cites W2019038259 @default.
- W3043758472 cites W2028771896 @default.
- W3043758472 cites W2029190950 @default.
- W3043758472 cites W2032812314 @default.
- W3043758472 cites W2034525368 @default.
- W3043758472 cites W2041181439 @default.
- W3043758472 cites W2042985928 @default.
- W3043758472 cites W2048799707 @default.
- W3043758472 cites W2050795269 @default.
- W3043758472 cites W2061816628 @default.
- W3043758472 cites W2062210004 @default.
- W3043758472 cites W2062366015 @default.
- W3043758472 cites W2066411725 @default.
- W3043758472 cites W2068807059 @default.
- W3043758472 cites W2076977009 @default.
- W3043758472 cites W2078615488 @default.
- W3043758472 cites W2079544897 @default.
- W3043758472 cites W2085907924 @default.
- W3043758472 cites W2089760449 @default.
- W3043758472 cites W2090106378 @default.
- W3043758472 cites W2090165151 @default.
- W3043758472 cites W2092283121 @default.
- W3043758472 cites W2121395439 @default.
- W3043758472 cites W2124408765 @default.
- W3043758472 cites W2126519286 @default.
- W3043758472 cites W2133755657 @default.
- W3043758472 cites W2137397455 @default.
- W3043758472 cites W2149874329 @default.
- W3043758472 cites W2157113151 @default.
- W3043758472 cites W2177465500 @default.
- W3043758472 cites W2200613921 @default.
- W3043758472 cites W2317557661 @default.
- W3043758472 cites W2345916356 @default.
- W3043758472 cites W2471394573 @default.
- W3043758472 cites W2530814929 @default.
- W3043758472 cites W2547933911 @default.
- W3043758472 cites W2575532686 @default.
- W3043758472 cites W2583594489 @default.
- W3043758472 cites W2602955328 @default.
- W3043758472 cites W2610052210 @default.
- W3043758472 cites W2709272656 @default.
- W3043758472 cites W2734700429 @default.
- W3043758472 cites W2781046317 @default.
- W3043758472 cites W2790601237 @default.
- W3043758472 cites W2792110517 @default.
- W3043758472 cites W2799553889 @default.
- W3043758472 cites W2802300590 @default.
- W3043758472 cites W2889327939 @default.
- W3043758472 cites W2920843279 @default.
- W3043758472 cites W2922039511 @default.
- W3043758472 cites W2947964466 @default.
- W3043758472 cites W2978326901 @default.
- W3043758472 cites W4293247451 @default.
- W3043758472 doi "https://doi.org/10.1016/j.chemosphere.2020.127678" @default.
- W3043758472 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32717509" @default.
- W3043758472 hasPublicationYear "2020" @default.
- W3043758472 type Work @default.