Matches in SemOpenAlex for { <https://semopenalex.org/work/W3043790623> ?p ?o ?g. }
- W3043790623 endingPage "C532" @default.
- W3043790623 startingPage "C510" @default.
- W3043790623 abstract "Neutrophils are polymorphonuclear leukocytes that play a central role in host defense against infection and tissue injury. They are rapidly recruited to the inflamed site and execute a variety of functions to clear invading pathogens and damaged cells. However, many of their defense mechanisms are capable of inflicting collateral tissue damage. Neutrophil-driven inflammation is a unifying mechanism underlying many common diseases. Efficient removal of neutrophils from inflammatory loci is critical for timely resolution of inflammation and return to homeostasis. Accumulating evidence challenges the classical view that neutrophils represent a homogeneous population and that halting neutrophil influx is sufficient to explain their rapid decline within inflamed loci during the resolution of protective inflammation. Hence, understanding the mechanisms that govern neutrophil functions and their removal from the inflammatory locus is critical for minimizing damage to the surrounding tissue and for return to homeostasis. In this review, we briefly address recent advances in characterizing neutrophil phenotypic and functional heterogeneity and the molecular mechanisms that determine the fate of neutrophils within inflammatory loci and the outcome of the inflammatory response. We also discuss how these mechanisms may be harnessed as potential therapeutic targets to facilitate resolution of inflammation." @default.
- W3043790623 created "2020-07-23" @default.
- W3043790623 creator A5023164058 @default.
- W3043790623 creator A5038048841 @default.
- W3043790623 date "2020-09-01" @default.
- W3043790623 modified "2023-10-06" @default.
- W3043790623 title "Neutrophil heterogeneity and fate in inflamed tissues: implications for the resolution of inflammation" @default.
- W3043790623 cites W146301169 @default.
- W3043790623 cites W1484922293 @default.
- W3043790623 cites W1497700962 @default.
- W3043790623 cites W1531140346 @default.
- W3043790623 cites W1533196655 @default.
- W3043790623 cites W1538565107 @default.
- W3043790623 cites W1556346244 @default.
- W3043790623 cites W1561928773 @default.
- W3043790623 cites W1564279536 @default.
- W3043790623 cites W1576773659 @default.
- W3043790623 cites W1670524885 @default.
- W3043790623 cites W1855747376 @default.
- W3043790623 cites W1856034726 @default.
- W3043790623 cites W1859771235 @default.
- W3043790623 cites W1864128415 @default.
- W3043790623 cites W1879486454 @default.
- W3043790623 cites W1911017997 @default.
- W3043790623 cites W1913879859 @default.
- W3043790623 cites W1920052832 @default.
- W3043790623 cites W1955937578 @default.
- W3043790623 cites W1959056525 @default.
- W3043790623 cites W1965394044 @default.
- W3043790623 cites W1968442371 @default.
- W3043790623 cites W1969944763 @default.
- W3043790623 cites W1973431219 @default.
- W3043790623 cites W1973511155 @default.
- W3043790623 cites W1974226247 @default.
- W3043790623 cites W1974392294 @default.
- W3043790623 cites W1975593978 @default.
- W3043790623 cites W1978346387 @default.
- W3043790623 cites W1978740584 @default.
- W3043790623 cites W1979004719 @default.
- W3043790623 cites W1979790110 @default.
- W3043790623 cites W1979872218 @default.
- W3043790623 cites W1979952143 @default.
- W3043790623 cites W1981926613 @default.
- W3043790623 cites W1982283061 @default.
- W3043790623 cites W1982873535 @default.
- W3043790623 cites W1983085370 @default.
- W3043790623 cites W1984554579 @default.
- W3043790623 cites W1984771489 @default.
- W3043790623 cites W1986182935 @default.
- W3043790623 cites W1986282241 @default.
- W3043790623 cites W1986296368 @default.
- W3043790623 cites W1986668505 @default.
- W3043790623 cites W1986734670 @default.
- W3043790623 cites W1987400327 @default.
- W3043790623 cites W1989111278 @default.
- W3043790623 cites W1989201814 @default.
- W3043790623 cites W1991562400 @default.
- W3043790623 cites W1994965038 @default.
- W3043790623 cites W1995831206 @default.
- W3043790623 cites W1998763175 @default.
- W3043790623 cites W1999224453 @default.
- W3043790623 cites W2001286841 @default.
- W3043790623 cites W2001972355 @default.
- W3043790623 cites W2002157461 @default.
- W3043790623 cites W2003224865 @default.
- W3043790623 cites W2003398489 @default.
- W3043790623 cites W2004536682 @default.
- W3043790623 cites W2004638361 @default.
- W3043790623 cites W2005631373 @default.
- W3043790623 cites W2006277579 @default.
- W3043790623 cites W2007767114 @default.
- W3043790623 cites W2009571354 @default.
- W3043790623 cites W2010717419 @default.
- W3043790623 cites W2011145349 @default.
- W3043790623 cites W2011881258 @default.
- W3043790623 cites W2013065585 @default.
- W3043790623 cites W2014466662 @default.
- W3043790623 cites W2014678245 @default.
- W3043790623 cites W2014776493 @default.
- W3043790623 cites W2016827757 @default.
- W3043790623 cites W2017338571 @default.
- W3043790623 cites W2019676650 @default.
- W3043790623 cites W2022443457 @default.
- W3043790623 cites W2023122823 @default.
- W3043790623 cites W2023385560 @default.
- W3043790623 cites W2023962283 @default.
- W3043790623 cites W2024216850 @default.
- W3043790623 cites W2027955807 @default.
- W3043790623 cites W2032227357 @default.
- W3043790623 cites W2033148258 @default.
- W3043790623 cites W2033644126 @default.
- W3043790623 cites W2034029474 @default.
- W3043790623 cites W2035809865 @default.
- W3043790623 cites W2038796948 @default.
- W3043790623 cites W2038955872 @default.
- W3043790623 cites W2040252933 @default.
- W3043790623 cites W2041831203 @default.
- W3043790623 cites W2042851093 @default.