Matches in SemOpenAlex for { <https://semopenalex.org/work/W3043804763> ?p ?o ?g. }
- W3043804763 endingPage "1017" @default.
- W3043804763 startingPage "1007" @default.
- W3043804763 abstract "Cardiac excitation-contraction (EC) coupling, which links plasma membrane depolarization to activation of cardiomyocyte contraction, occurs at dyads, the nanoscopic microdomains formed by apposition of transverse (T)-tubules and junctional sarcoplasmic reticulum (jSR). In a dyadic junction, EC coupling occurs through Ca2+-induced Ca2+ release. Membrane depolarization opens voltage-gated L-type Ca2+ channels (LTCCs) in the T-tubule. The resulting influx of extracellular Ca2+ into the dyadic cleft opens Ca2+ release channels known as ryanodine receptors (RYRs) in the jSR, leading to the rapid increase in cytosolic Ca2+ that triggers sarcomere contraction. The efficacy of LTCC-RYR communication greatly affects a myriad of downstream intracellular signaling events, and it is controlled by many factors, including T-tubule and jSR structure, spatial distribution of ion channels, and regulatory proteins that closely regulate the activities of channels within dyads. Alterations in dyad architecture and/or channel activity are seen in many types of heart disease. This review will focus on the current knowledge regarding cardiac dyad structure and function, their alterations in heart failure, and new approaches to study the composition and function of dyads." @default.
- W3043804763 created "2020-07-23" @default.
- W3043804763 creator A5004439062 @default.
- W3043804763 creator A5005371628 @default.
- W3043804763 date "2020-07-13" @default.
- W3043804763 modified "2023-09-25" @default.
- W3043804763 title "The architecture and function of cardiac dyads" @default.
- W3043804763 cites W1509611865 @default.
- W3043804763 cites W1538404780 @default.
- W3043804763 cites W1551217436 @default.
- W3043804763 cites W1605990605 @default.
- W3043804763 cites W1660040913 @default.
- W3043804763 cites W1838570785 @default.
- W3043804763 cites W1857532475 @default.
- W3043804763 cites W1963623014 @default.
- W3043804763 cites W1963851776 @default.
- W3043804763 cites W1970019262 @default.
- W3043804763 cites W1983724756 @default.
- W3043804763 cites W1987369449 @default.
- W3043804763 cites W1988595073 @default.
- W3043804763 cites W1989113874 @default.
- W3043804763 cites W1995116585 @default.
- W3043804763 cites W1996344039 @default.
- W3043804763 cites W2003290962 @default.
- W3043804763 cites W2007130189 @default.
- W3043804763 cites W2012751980 @default.
- W3043804763 cites W2013798123 @default.
- W3043804763 cites W2018818697 @default.
- W3043804763 cites W2021693681 @default.
- W3043804763 cites W2023169137 @default.
- W3043804763 cites W2023758830 @default.
- W3043804763 cites W2034401785 @default.
- W3043804763 cites W2035030688 @default.
- W3043804763 cites W2036424054 @default.
- W3043804763 cites W2039958324 @default.
- W3043804763 cites W2046526051 @default.
- W3043804763 cites W2046701128 @default.
- W3043804763 cites W2046759637 @default.
- W3043804763 cites W2050824263 @default.
- W3043804763 cites W2053330560 @default.
- W3043804763 cites W2054225000 @default.
- W3043804763 cites W2054554932 @default.
- W3043804763 cites W2055235191 @default.
- W3043804763 cites W2059850967 @default.
- W3043804763 cites W2062157267 @default.
- W3043804763 cites W2065076724 @default.
- W3043804763 cites W2067991877 @default.
- W3043804763 cites W2068613600 @default.
- W3043804763 cites W2070500034 @default.
- W3043804763 cites W2071405805 @default.
- W3043804763 cites W2074777877 @default.
- W3043804763 cites W2075970710 @default.
- W3043804763 cites W2088940841 @default.
- W3043804763 cites W2097733771 @default.
- W3043804763 cites W2098476525 @default.
- W3043804763 cites W2099717511 @default.
- W3043804763 cites W2101242392 @default.
- W3043804763 cites W2102311103 @default.
- W3043804763 cites W2105664556 @default.
- W3043804763 cites W2105998387 @default.
- W3043804763 cites W2106972592 @default.
- W3043804763 cites W2109554150 @default.
- W3043804763 cites W2109665703 @default.
- W3043804763 cites W2111394029 @default.
- W3043804763 cites W2111577676 @default.
- W3043804763 cites W2112180900 @default.
- W3043804763 cites W2113183554 @default.
- W3043804763 cites W2114329647 @default.
- W3043804763 cites W2115293476 @default.
- W3043804763 cites W2122817391 @default.
- W3043804763 cites W2130264694 @default.
- W3043804763 cites W2130443890 @default.
- W3043804763 cites W2135515146 @default.
- W3043804763 cites W2140368058 @default.
- W3043804763 cites W2149967863 @default.
- W3043804763 cites W2155271904 @default.
- W3043804763 cites W2163736419 @default.
- W3043804763 cites W2166278741 @default.
- W3043804763 cites W2170643083 @default.
- W3043804763 cites W2240308484 @default.
- W3043804763 cites W2296672878 @default.
- W3043804763 cites W2404165395 @default.
- W3043804763 cites W2531200829 @default.
- W3043804763 cites W2557105573 @default.
- W3043804763 cites W2569513212 @default.
- W3043804763 cites W2602896452 @default.
- W3043804763 cites W2606518766 @default.
- W3043804763 cites W2625994551 @default.
- W3043804763 cites W2739459547 @default.
- W3043804763 cites W2764024258 @default.
- W3043804763 cites W2794616878 @default.
- W3043804763 cites W2809355380 @default.
- W3043804763 cites W2889940320 @default.
- W3043804763 cites W2898269107 @default.
- W3043804763 cites W2899411827 @default.
- W3043804763 cites W2899864753 @default.
- W3043804763 cites W2912096548 @default.
- W3043804763 cites W2936481753 @default.