FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3043855777> ?p ?o ?g. }

• W3043855777 endingPage "e00210" @default.
• W3043855777 startingPage "e00210" @default.
• W3043855777 abstract "INTRODUCTION: Colorectal cancer is a common malignancy that can be cured when detected early, but recurrence among survivors is a persistent risk. A field effect of cancer in the colon has been reported and could have implications for surveillance, but studies to date have been limited. A joint analysis of pooled transcriptomic data from all available bulk RNA-sequencing data sets of healthy, histologically normal tumor-adjacent, and tumor tissues was performed to provide an unbiased assessment of field effect. METHODS: A novel bulk RNA-sequencing data set from biopsies of nondiseased colon from screening colonoscopy along with published data sets from the Genomic Data Commons and Sequence Read Archive were considered for inclusion. Analyses were limited to samples with a quantified read depth of at least 10 million reads. Transcript abundance was estimated with Salmon, and downstream analysis was performed in R. RESULTS: A total of 1,139 samples were analyzed in 3 cohorts. The primary cohort consisted of 834 independent samples from 8 independent data sets, including 462 healthy, 61 tumor-adjacent, and 311 tumor samples. Tumor-adjacent gene expression was found to represent an intermediate state between healthy and tumor expression. Among differentially expressed genes in tumor-adjacent samples, 1,143 were expressed in patterns similar to tumor samples, and these genes were enriched for cancer-associated pathways. DISCUSSION: Novel insights into the field effect in colorectal cancer were generated in this mega-analysis of the colorectal transcriptome. Oncogenic features that might help explain metachronous lesions in cancer survivors and could be used for surveillance and risk stratification were identified." @default.
• W3043855777 created "2020-07-29" @default.
• W3043855777 creator A5002125452 @default.
• W3043855777 creator A5033227663 @default.
• W3043855777 creator A5043007882 @default.
• W3043855777 creator A5047971569 @default.
• W3043855777 creator A5048013245 @default.
• W3043855777 creator A5073601044 @default.
• W3043855777 creator A5084496654 @default.
• W3043855777 date "2020-07-01" @default.
• W3043855777 modified "2023-10-16" @default.
• W3043855777 title "Oncogenic Features in Histologically Normal Mucosa: Novel Insights Into Field Effect From a Mega-Analysis of Colorectal Transcriptomes" @default.
• W3043855777 cites W1754741317 @default.
• W3043855777 cites W1934094702 @default.
• W3043855777 cites W1973094248 @default.
• W3043855777 cites W1975635514 @default.
• W3043855777 cites W1978351270 @default.
• W3043855777 cites W1991949008 @default.
• W3043855777 cites W2024919757 @default.
• W3043855777 cites W2038206960 @default.
• W3043855777 cites W2064010630 @default.
• W3043855777 cites W2064051662 @default.
• W3043855777 cites W2066253321 @default.
• W3043855777 cites W2095718447 @default.
• W3043855777 cites W2096205403 @default.
• W3043855777 cites W2106316660 @default.
• W3043855777 cites W2106789440 @default.
• W3043855777 cites W2111627225 @default.
• W3043855777 cites W2115003883 @default.
• W3043855777 cites W2127372456 @default.
• W3043855777 cites W2137499573 @default.
• W3043855777 cites W2152501601 @default.
• W3043855777 cites W2157214221 @default.
• W3043855777 cites W2179438025 @default.
• W3043855777 cites W2214074259 @default.
• W3043855777 cites W2265972204 @default.
• W3043855777 cites W2490738267 @default.
• W3043855777 cites W2573216870 @default.
• W3043855777 cites W2749613778 @default.
• W3043855777 cites W2766676715 @default.
• W3043855777 cites W2801400022 @default.
• W3043855777 cites W2890433724 @default.
• W3043855777 cites W2892831467 @default.
• W3043855777 cites W2899615648 @default.
• W3043855777 cites W2902093446 @default.
• W3043855777 cites W2903753708 @default.
• W3043855777 cites W2952990620 @default.
• W3043855777 cites W4237969733 @default.
• W3043855777 doi "https://doi.org/10.14309/ctg.0000000000000210" @default.
• W3043855777 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7386360" @default.
• W3043855777 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32764205" @default.
• W3043855777 hasPublicationYear "2020" @default.
• W3043855777 type Work @default.
• W3043855777 sameAs 3043855777 @default.
• W3043855777 citedByCount "9" @default.
• W3043855777 countsByYear W30438557772021 @default.
• W3043855777 countsByYear W30438557772022 @default.
• W3043855777 countsByYear W30438557772023 @default.
• W3043855777 crossrefType "journal-article" @default.
• W3043855777 hasAuthorship W3043855777A5002125452 @default.
• W3043855777 hasAuthorship W3043855777A5033227663 @default.
• W3043855777 hasAuthorship W3043855777A5043007882 @default.
• W3043855777 hasAuthorship W3043855777A5047971569 @default.
• W3043855777 hasAuthorship W3043855777A5048013245 @default.
• W3043855777 hasAuthorship W3043855777A5073601044 @default.
• W3043855777 hasAuthorship W3043855777A5084496654 @default.
• W3043855777 hasBestOaLocation W30438557771 @default.
• W3043855777 hasConcept C104317684 @default.
• W3043855777 hasConcept C121608353 @default.
• W3043855777 hasConcept C126322002 @default.
• W3043855777 hasConcept C142724271 @default.
• W3043855777 hasConcept C143998085 @default.
• W3043855777 hasConcept C150194340 @default.
• W3043855777 hasConcept C162317418 @default.
• W3043855777 hasConcept C2779399171 @default.
• W3043855777 hasConcept C502942594 @default.
• W3043855777 hasConcept C526805850 @default.
• W3043855777 hasConcept C54355233 @default.
• W3043855777 hasConcept C60644358 @default.
• W3043855777 hasConcept C71924100 @default.
• W3043855777 hasConcept C86803240 @default.
• W3043855777 hasConceptScore W3043855777C104317684 @default.
• W3043855777 hasConceptScore W3043855777C121608353 @default.
• W3043855777 hasConceptScore W3043855777C126322002 @default.
• W3043855777 hasConceptScore W3043855777C142724271 @default.
• W3043855777 hasConceptScore W3043855777C143998085 @default.
• W3043855777 hasConceptScore W3043855777C150194340 @default.
• W3043855777 hasConceptScore W3043855777C162317418 @default.
• W3043855777 hasConceptScore W3043855777C2779399171 @default.
• W3043855777 hasConceptScore W3043855777C502942594 @default.
• W3043855777 hasConceptScore W3043855777C526805850 @default.
• W3043855777 hasConceptScore W3043855777C54355233 @default.
• W3043855777 hasConceptScore W3043855777C60644358 @default.
• W3043855777 hasConceptScore W3043855777C71924100 @default.
• W3043855777 hasConceptScore W3043855777C86803240 @default.
• W3043855777 hasIssue "7" @default.
• W3043855777 hasLocation W30438557771 @default.
• W3043855777 hasLocation W30438557772 @default.

• next