Matches in SemOpenAlex for { <https://semopenalex.org/work/W3043921167> ?p ?o ?g. }
- W3043921167 abstract "Nucleoporins (Nups) build highly organized nuclear pore complexes (NPCs) at the nuclear envelope (NE). Several Nups assemble into a sieve-like hydrogel within the central channel of the NPCs. In the cytoplasm, the soluble Nups exist, but how their assembly is restricted to the NE is currently unknown. Here, we show that fragile X-related protein 1 (FXR1) can interact with several Nups and facilitate their localization to the NE during interphase through a microtubule-dependent mechanism. Downregulation of FXR1 or closely related orthologs FXR2 and fragile X mental retardation protein (FMRP) leads to the accumulation of cytoplasmic Nup condensates. Likewise, models of fragile X syndrome (FXS), characterized by a loss of FMRP, accumulate Nup granules. The Nup granule-containing cells show defects in protein export, nuclear morphology and cell cycle progression. Our results reveal an unexpected role for the FXR protein family in the spatial regulation of nucleoporin condensation." @default.
- W3043921167 created "2020-07-29" @default.
- W3043921167 creator A5003412185 @default.
- W3043921167 creator A5003744868 @default.
- W3043921167 creator A5009591144 @default.
- W3043921167 creator A5013924044 @default.
- W3043921167 creator A5018759129 @default.
- W3043921167 creator A5026031769 @default.
- W3043921167 creator A5029142790 @default.
- W3043921167 creator A5031564211 @default.
- W3043921167 creator A5042710643 @default.
- W3043921167 creator A5048568316 @default.
- W3043921167 creator A5076029433 @default.
- W3043921167 creator A5084557570 @default.
- W3043921167 creator A5086204590 @default.
- W3043921167 creator A5087992070 @default.
- W3043921167 creator A5091847535 @default.
- W3043921167 date "2020-07-24" @default.
- W3043921167 modified "2023-10-01" @default.
- W3043921167 title "Spatial control of nucleoporin condensation by fragile X‐related proteins" @default.
- W3043921167 cites W1531040695 @default.
- W3043921167 cites W1558287800 @default.
- W3043921167 cites W1755917942 @default.
- W3043921167 cites W1854281301 @default.
- W3043921167 cites W1894813487 @default.
- W3043921167 cites W1899765255 @default.
- W3043921167 cites W1901789611 @default.
- W3043921167 cites W1934819143 @default.
- W3043921167 cites W1968975193 @default.
- W3043921167 cites W1970300777 @default.
- W3043921167 cites W1971411282 @default.
- W3043921167 cites W1996113224 @default.
- W3043921167 cites W2015646338 @default.
- W3043921167 cites W2022506021 @default.
- W3043921167 cites W2024160864 @default.
- W3043921167 cites W2024387549 @default.
- W3043921167 cites W2030053673 @default.
- W3043921167 cites W2031989334 @default.
- W3043921167 cites W2037516997 @default.
- W3043921167 cites W2059291367 @default.
- W3043921167 cites W2071130662 @default.
- W3043921167 cites W2071883855 @default.
- W3043921167 cites W2075186362 @default.
- W3043921167 cites W2076870182 @default.
- W3043921167 cites W2082315566 @default.
- W3043921167 cites W2089423013 @default.
- W3043921167 cites W2089927164 @default.
- W3043921167 cites W2101949381 @default.
- W3043921167 cites W2103851941 @default.
- W3043921167 cites W2104777962 @default.
- W3043921167 cites W2111560040 @default.
- W3043921167 cites W2116174991 @default.
- W3043921167 cites W2120508681 @default.
- W3043921167 cites W2122579813 @default.
- W3043921167 cites W2122823449 @default.
- W3043921167 cites W2123824748 @default.
- W3043921167 cites W2141339789 @default.
- W3043921167 cites W2153894357 @default.
- W3043921167 cites W2160226734 @default.
- W3043921167 cites W2171041801 @default.
- W3043921167 cites W2214808389 @default.
- W3043921167 cites W2293002570 @default.
- W3043921167 cites W2464250025 @default.
- W3043921167 cites W2534118568 @default.
- W3043921167 cites W2552134372 @default.
- W3043921167 cites W2564335181 @default.
- W3043921167 cites W2604909829 @default.
- W3043921167 cites W2612667602 @default.
- W3043921167 cites W2756821926 @default.
- W3043921167 cites W2763332188 @default.
- W3043921167 cites W2768681263 @default.
- W3043921167 cites W2789548112 @default.
- W3043921167 cites W2793417714 @default.
- W3043921167 cites W2794654572 @default.
- W3043921167 cites W2795968456 @default.
- W3043921167 cites W2796205057 @default.
- W3043921167 cites W2909737074 @default.
- W3043921167 cites W2914861971 @default.
- W3043921167 cites W2923019381 @default.
- W3043921167 cites W2926429612 @default.
- W3043921167 cites W2935467328 @default.
- W3043921167 cites W2949816574 @default.
- W3043921167 cites W2954520844 @default.
- W3043921167 cites W2969881735 @default.
- W3043921167 cites W2980631159 @default.
- W3043921167 doi "https://doi.org/10.15252/embj.2020104467" @default.
- W3043921167 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7560220" @default.
- W3043921167 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32706158" @default.
- W3043921167 hasPublicationYear "2020" @default.
- W3043921167 type Work @default.
- W3043921167 sameAs 3043921167 @default.
- W3043921167 citedByCount "14" @default.
- W3043921167 countsByYear W30439211672020 @default.
- W3043921167 countsByYear W30439211672021 @default.
- W3043921167 countsByYear W30439211672022 @default.
- W3043921167 countsByYear W30439211672023 @default.
- W3043921167 crossrefType "journal-article" @default.
- W3043921167 hasAuthorship W3043921167A5003412185 @default.
- W3043921167 hasAuthorship W3043921167A5003744868 @default.
- W3043921167 hasAuthorship W3043921167A5009591144 @default.