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• W3043933595 abstract "Abstract MOG-antibody associated disease (MOG-AAD) is a recently recognized demyelinating disorder predominantly affecting children but also occurs in adults, with a relapsing course in approximately 50% of patients. We evaluated peripheral blood mononuclear cells from MOG-AAD patients by flow cytometry and found a strong antigen specific central memory cell (CMC) response with increased Th1 and Th17 cells at the time of a relapse. Transcriptomic analysis of CMCs by three independent sequencing platforms revealed TNFAIP3 as a relapse biomarker, whose expression was down regulated at a relapse compared to remission in MOG-AAD patients. Serum in an additional cohort of patients showed decreased TNFAIP3 levels at relapse compared to remission state in MOG-AAD patients. Our studies suggest that alterations in TNFAIP3 levels are associated with relapses in MOG-AAD patients, which may have clinical utility as a disease course biomarker and therapeutic target." @default.
• W3043933595 created "2020-07-29" @default.
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• W3043933595 date "2020-07-24" @default.
• W3043933595 modified "2023-10-11" @default.
• W3043933595 title "Identification of TNFAIP3 as relapse biomarker and potential therapeutic target for MOG antibody associated diseases" @default.
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• W3043933595 doi "https://doi.org/10.1038/s41598-020-69182-w" @default.
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