FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3043933718> ?p ?o ?g. }

• W3043933718 endingPage "110549" @default.
• W3043933718 startingPage "110549" @default.
• W3043933718 abstract "Current anti-cancer drugs can cause many undesirable side effects to patients. Thus, there is a constant need to develop alternative therapeutic drugs. Bioactive compounds derived from natural products including animals, plants and microorganisms are being actively studied as sources for anticancer treatments. Freshwater planarians are important models for stem cell research and regeneration. However, to date, no studies on the biological activities of planaria extracts on cancer have been published. The aim of this study was to examine the potential antitumoral activity of the extract from planaria species-Malta (PSM) on human acute myeloid leukemia (AML) HL-60 cells. Antiproliferative activity was studied in terms of proliferation, apoptosis and differentiation. The expression of genes involved in the regulation of these important cellular processes was also analyzed using real-time PCR. PSM extract exhibited a selective cytotoxic effect on HL-60 cells when compared to normal lymphocytes. Furthermore, cell cycle analysis and Annexin V/PI assay showed that the extract induced apoptosis in HL-60 cells. The PSM extract induced myeloid differentiation with HL-60 cells showing a decreased nucleo/cytoplasmic ratio, an increase in nitroblue tetrazolium-positive cells, and CD11b- and CD14-positive cells. Finally, we also found that the PSM extract increased the expression of CEBPA, CEBPB, CEBPE, SPI1, BAX, CDKN1A and CDKN2C; whereas it reduced the expression of c-MYC and BCL2. This is the first study to reveal the antiproliferative, cytotoxic, and differentiation potential of PSM on HL-60 cells and suggests that it may have considerable potential for development as a novel natural product-based anticancer agent against AML." @default.
• W3043933718 created "2020-07-29" @default.
• W3043933718 creator A5006181265 @default.
• W3043933718 creator A5024674423 @default.
• W3043933718 creator A5032163142 @default.
• W3043933718 creator A5080064542 @default.
• W3043933718 creator A5083945756 @default.
• W3043933718 creator A5091487919 @default.
• W3043933718 date "2020-10-01" @default.
• W3043933718 modified "2023-10-01" @default.
• W3043933718 title "Anticancer effects of an extract from a local planarian species on human acute myeloid leukemia HL-60 cells in vitro" @default.
• W3043933718 cites W1577577364 @default.
• W3043933718 cites W1978275266 @default.
• W3043933718 cites W1992448994 @default.
• W3043933718 cites W1992716708 @default.
• W3043933718 cites W1997046657 @default.
• W3043933718 cites W1999604714 @default.
• W3043933718 cites W2035576418 @default.
• W3043933718 cites W2044013798 @default.
• W3043933718 cites W2044596216 @default.
• W3043933718 cites W2069919657 @default.
• W3043933718 cites W2103244742 @default.
• W3043933718 cites W2107277218 @default.
• W3043933718 cites W2112082425 @default.
• W3043933718 cites W2122465033 @default.
• W3043933718 cites W2131110992 @default.
• W3043933718 cites W2133039575 @default.
• W3043933718 cites W2133047652 @default.
• W3043933718 cites W2161054114 @default.
• W3043933718 cites W2161671321 @default.
• W3043933718 cites W2165625463 @default.
• W3043933718 cites W2184083116 @default.
• W3043933718 cites W2206283449 @default.
• W3043933718 cites W2527169367 @default.
• W3043933718 cites W2772237312 @default.
• W3043933718 cites W2801482851 @default.
• W3043933718 cites W2807921412 @default.
• W3043933718 cites W2810223515 @default.
• W3043933718 cites W2908717823 @default.
• W3043933718 cites W2915293258 @default.
• W3043933718 cites W2942855506 @default.
• W3043933718 cites W2948765831 @default.
• W3043933718 cites W2953059837 @default.
• W3043933718 cites W2969876208 @default.
• W3043933718 cites W2982006255 @default.
• W3043933718 cites W3007255956 @default.
• W3043933718 cites W3011366455 @default.
• W3043933718 cites W4253702721 @default.
• W3043933718 cites W4301014712 @default.
• W3043933718 cites W630097483 @default.
• W3043933718 cites W1972396766 @default.
• W3043933718 doi "https://doi.org/10.1016/j.biopha.2020.110549" @default.
• W3043933718 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32726743" @default.
• W3043933718 hasPublicationYear "2020" @default.
• W3043933718 type Work @default.
• W3043933718 sameAs 3043933718 @default.
• W3043933718 citedByCount "3" @default.
• W3043933718 countsByYear W30439337182021 @default.
• W3043933718 countsByYear W30439337182022 @default.
• W3043933718 crossrefType "journal-article" @default.
• W3043933718 hasAuthorship W3043933718A5006181265 @default.
• W3043933718 hasAuthorship W3043933718A5024674423 @default.
• W3043933718 hasAuthorship W3043933718A5032163142 @default.
• W3043933718 hasAuthorship W3043933718A5080064542 @default.
• W3043933718 hasAuthorship W3043933718A5083945756 @default.
• W3043933718 hasAuthorship W3043933718A5091487919 @default.
• W3043933718 hasBestOaLocation W30439337181 @default.
• W3043933718 hasConcept C104317684 @default.
• W3043933718 hasConcept C109159458 @default.
• W3043933718 hasConcept C121608353 @default.
• W3043933718 hasConcept C154317977 @default.
• W3043933718 hasConcept C185592680 @default.
• W3043933718 hasConcept C190283241 @default.
• W3043933718 hasConcept C202751555 @default.
• W3043933718 hasConcept C203014093 @default.
• W3043933718 hasConcept C2778461978 @default.
• W3043933718 hasConcept C2778729363 @default.
• W3043933718 hasConcept C28328180 @default.
• W3043933718 hasConcept C45091340 @default.
• W3043933718 hasConcept C502942594 @default.
• W3043933718 hasConcept C54355233 @default.
• W3043933718 hasConcept C55493867 @default.
• W3043933718 hasConcept C86339819 @default.
• W3043933718 hasConcept C86803240 @default.
• W3043933718 hasConcept C95444343 @default.
• W3043933718 hasConcept C96232424 @default.
• W3043933718 hasConcept C98274493 @default.
• W3043933718 hasConceptScore W3043933718C104317684 @default.
• W3043933718 hasConceptScore W3043933718C109159458 @default.
• W3043933718 hasConceptScore W3043933718C121608353 @default.
• W3043933718 hasConceptScore W3043933718C154317977 @default.
• W3043933718 hasConceptScore W3043933718C185592680 @default.
• W3043933718 hasConceptScore W3043933718C190283241 @default.
• W3043933718 hasConceptScore W3043933718C202751555 @default.
• W3043933718 hasConceptScore W3043933718C203014093 @default.
• W3043933718 hasConceptScore W3043933718C2778461978 @default.
• W3043933718 hasConceptScore W3043933718C2778729363 @default.
• W3043933718 hasConceptScore W3043933718C28328180 @default.

• next