Matches in SemOpenAlex for { <https://semopenalex.org/work/W3043953303> ?p ?o ?g. }
- W3043953303 endingPage "49" @default.
- W3043953303 startingPage "49" @default.
- W3043953303 abstract "Background: The last two decades has been characterized by accruing evidence of the translational relevance of chromatin modification in normal genomic function, regulation, and pathology, especially with piqued interest in the intrinsic regulatory dynamism of histone methylation, and the increasing documentation of new members of the histone demethylase family. Recent studies provide functional and mechanistic insight into the peculiar biological role of these histone demethylases and their putative implication in pathological processes. Objective: This review aims to provide a summary of the latest findings related to pleiotropic roles of the Jumonji/AT-rich interactive domain (JARID) domain-containing lysine demethylase 5B (KDM5B, also known as JARID1B or PLU1) in physiology and pathology, with a focus on its therapeutic potentials. Results: KDM5B/JARID1B/PLU1 is restrictively expressed, evolutionarily conserved across mammalian species, and belonging to the α-ketoglutarate-dependent hydroxylase superfamily. KDM5B is actively involved in various physiological processes, including regulation of transcription elongation and alternative splicing in embryonic stem cells, epigenetic modulation of gene expression, neurogenesis, mammary gland development, and osteogenesis. Conversely, KDM5B is one of the earliest identified histone lysine demethylases associated with human disease, with several studies indicating that KDM5B plays a vital role in the initiation and progression of various malignancies, including lung, hypopharynx, brain, and breast cancers. Conclusion: This study provides concise insight into the functional pleiotropism of KDM5B in physiology and pathology, as well as highlights it role as an actionable therapeutic target." @default.
- W3043953303 created "2020-07-29" @default.
- W3043953303 creator A5071664405 @default.
- W3043953303 creator A5088731206 @default.
- W3043953303 date "2020-01-01" @default.
- W3043953303 modified "2023-09-23" @default.
- W3043953303 title "Dissecting the functional pleiotropism of lysine demethylase 5B in physiology and pathology" @default.
- W3043953303 cites W1454152321 @default.
- W3043953303 cites W1734882305 @default.
- W3043953303 cites W1847634070 @default.
- W3043953303 cites W1963789736 @default.
- W3043953303 cites W1966985390 @default.
- W3043953303 cites W1971464471 @default.
- W3043953303 cites W1982409009 @default.
- W3043953303 cites W1985594917 @default.
- W3043953303 cites W1992323285 @default.
- W3043953303 cites W1992963525 @default.
- W3043953303 cites W1995103178 @default.
- W3043953303 cites W1997587039 @default.
- W3043953303 cites W1998137132 @default.
- W3043953303 cites W1999291910 @default.
- W3043953303 cites W2000519327 @default.
- W3043953303 cites W2006856548 @default.
- W3043953303 cites W2008627757 @default.
- W3043953303 cites W2008878539 @default.
- W3043953303 cites W2011006223 @default.
- W3043953303 cites W2015039345 @default.
- W3043953303 cites W2015735594 @default.
- W3043953303 cites W2019485601 @default.
- W3043953303 cites W2023997559 @default.
- W3043953303 cites W2024052509 @default.
- W3043953303 cites W2026380005 @default.
- W3043953303 cites W2026783122 @default.
- W3043953303 cites W2034882046 @default.
- W3043953303 cites W2050175703 @default.
- W3043953303 cites W2054659582 @default.
- W3043953303 cites W2057600412 @default.
- W3043953303 cites W2062074914 @default.
- W3043953303 cites W2063756611 @default.
- W3043953303 cites W2069725730 @default.
- W3043953303 cites W2072227338 @default.
- W3043953303 cites W2075552693 @default.
- W3043953303 cites W2078003979 @default.
- W3043953303 cites W2082662254 @default.
- W3043953303 cites W2084885369 @default.
- W3043953303 cites W2088737679 @default.
- W3043953303 cites W2093131463 @default.
- W3043953303 cites W2096550742 @default.
- W3043953303 cites W2097055124 @default.
- W3043953303 cites W2104870341 @default.
- W3043953303 cites W2105470231 @default.
- W3043953303 cites W2111915989 @default.
- W3043953303 cites W2112313406 @default.
- W3043953303 cites W2119088658 @default.
- W3043953303 cites W2122092305 @default.
- W3043953303 cites W2122234165 @default.
- W3043953303 cites W2137987484 @default.
- W3043953303 cites W2138127544 @default.
- W3043953303 cites W2141991853 @default.
- W3043953303 cites W2146940512 @default.
- W3043953303 cites W2147524392 @default.
- W3043953303 cites W2148720840 @default.
- W3043953303 cites W2149736989 @default.
- W3043953303 cites W2152528416 @default.
- W3043953303 cites W2153991114 @default.
- W3043953303 cites W2155259040 @default.
- W3043953303 cites W2155744133 @default.
- W3043953303 cites W2156816709 @default.
- W3043953303 cites W2160167945 @default.
- W3043953303 cites W2161224111 @default.
- W3043953303 cites W2161241553 @default.
- W3043953303 cites W2162643053 @default.
- W3043953303 cites W2167315449 @default.
- W3043953303 cites W2169566697 @default.
- W3043953303 cites W2171750268 @default.
- W3043953303 cites W2172208515 @default.
- W3043953303 cites W2178453614 @default.
- W3043953303 cites W2194186986 @default.
- W3043953303 cites W2195762490 @default.
- W3043953303 cites W2211837538 @default.
- W3043953303 cites W2214266235 @default.
- W3043953303 cites W2250212759 @default.
- W3043953303 cites W2278682036 @default.
- W3043953303 cites W2281405031 @default.
- W3043953303 cites W2285997904 @default.
- W3043953303 cites W2319224523 @default.
- W3043953303 cites W2331098390 @default.
- W3043953303 cites W2415866521 @default.
- W3043953303 cites W2462735792 @default.
- W3043953303 cites W2512307284 @default.
- W3043953303 cites W2529451330 @default.
- W3043953303 cites W2552021993 @default.
- W3043953303 cites W2571971789 @default.
- W3043953303 cites W2606710471 @default.
- W3043953303 cites W2607585298 @default.
- W3043953303 cites W2621386467 @default.
- W3043953303 cites W2730785100 @default.
- W3043953303 cites W2745921792 @default.