Matches in SemOpenAlex for { <https://semopenalex.org/work/W3043955071> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W3043955071 endingPage "148" @default.
- W3043955071 startingPage "148" @default.
- W3043955071 abstract "628 Gold(I) phosphine derivatives have previously attracted interest as potential antitumour agents but hepatotoxicity was encountered during preclinical development. A series of bidentate pyridyl phosphine gold(I) and silver(I) complexes were synthesised covering a range of lipophilic/hydrophilic properties. Previously we reported that their lipophilicity greatly affects cellular uptake and cytotoxicity in a CH1 cell line. Herein we examined their in vitro uptake and cytotoxicity in a panel of human ovarian tumor cell lines and isolated hepatocytes. Sulforhodamine B assay and lactate dehydrogenase release assay were used to determine tumor cell growth inhibition and hepatocyte viability. Gold content was analyzed by inductively coupled plasma mass spectrometry. The in vitro cytotoxicity of bidentate pyridyl phosphine complexes to isolated hepatocytes and ovarian tumor cell lines correlated with their lipophilicity and rate of gold uptake. The 3- and 4-pyridyl derivatives showed less hepatotoxicity, slower cellular uptake and marked cytotoxicity to 2-deoxy-D-glucose-sensitive tumor cell lines. The cellular uptake of the 2-pyridyl gold(I) phosphine complex was partially inhibited by the membrane potential inhibitor valinomycin, and was higher in mitochondria relative to cytosolic and nuclear fractions. Unlike the phenyl phosphine gold(I) complex, the 2- and 4-pyridyl derivatives did not induce hepatotoxicity in vivo and showed lower gold accumulation in liver relative to tumor. In conclusion, the in vitro cytotoxicity of bidentate pyridyl phosphine gold(I) and silver(I) complexes to isolated hepatocytes and tumor cell lines correlated with their lipophilic/hydrophilic properties and cellular uptake. Their hepatotoxicity and antitumour activity may be due to their direct cytotoxicity, interference with energy metabolism and preferential accumulation in mitochondria. The Auckland Medical Research Foundation, the Wellcome Trust, and the Auckland Division of the Cancer Society of New Zealand supported the work." @default.
- W3043955071 created "2020-07-29" @default.
- W3043955071 creator A5000208785 @default.
- W3043955071 creator A5005045806 @default.
- W3043955071 creator A5025274254 @default.
- W3043955071 creator A5038498358 @default.
- W3043955071 creator A5048269061 @default.
- W3043955071 creator A5056481563 @default.
- W3043955071 creator A5061684371 @default.
- W3043955071 creator A5074741791 @default.
- W3043955071 creator A5084661473 @default.
- W3043955071 creator A5088930878 @default.
- W3043955071 creator A5089835420 @default.
- W3043955071 date "2005-05-01" @default.
- W3043955071 modified "2023-09-28" @default.
- W3043955071 title "In vitro studies of bidentate pyridyl phosphine gold(I) and silver(I) complexes as potential antitumour agents in ovarian tumor cell lines and isolated hepatocytes" @default.
- W3043955071 hasPublicationYear "2005" @default.
- W3043955071 type Work @default.
- W3043955071 sameAs 3043955071 @default.
- W3043955071 citedByCount "0" @default.
- W3043955071 crossrefType "journal-article" @default.
- W3043955071 hasAuthorship W3043955071A5000208785 @default.
- W3043955071 hasAuthorship W3043955071A5005045806 @default.
- W3043955071 hasAuthorship W3043955071A5025274254 @default.
- W3043955071 hasAuthorship W3043955071A5038498358 @default.
- W3043955071 hasAuthorship W3043955071A5048269061 @default.
- W3043955071 hasAuthorship W3043955071A5056481563 @default.
- W3043955071 hasAuthorship W3043955071A5061684371 @default.
- W3043955071 hasAuthorship W3043955071A5074741791 @default.
- W3043955071 hasAuthorship W3043955071A5084661473 @default.
- W3043955071 hasAuthorship W3043955071A5088930878 @default.
- W3043955071 hasAuthorship W3043955071A5089835420 @default.
- W3043955071 hasConcept C109316439 @default.
- W3043955071 hasConcept C185592680 @default.
- W3043955071 hasConcept C201399114 @default.
- W3043955071 hasConcept C202751555 @default.
- W3043955071 hasConcept C2776200302 @default.
- W3043955071 hasConcept C53227056 @default.
- W3043955071 hasConcept C54355233 @default.
- W3043955071 hasConcept C55493867 @default.
- W3043955071 hasConcept C81885089 @default.
- W3043955071 hasConcept C86803240 @default.
- W3043955071 hasConceptScore W3043955071C109316439 @default.
- W3043955071 hasConceptScore W3043955071C185592680 @default.
- W3043955071 hasConceptScore W3043955071C201399114 @default.
- W3043955071 hasConceptScore W3043955071C202751555 @default.
- W3043955071 hasConceptScore W3043955071C2776200302 @default.
- W3043955071 hasConceptScore W3043955071C53227056 @default.
- W3043955071 hasConceptScore W3043955071C54355233 @default.
- W3043955071 hasConceptScore W3043955071C55493867 @default.
- W3043955071 hasConceptScore W3043955071C81885089 @default.
- W3043955071 hasConceptScore W3043955071C86803240 @default.
- W3043955071 hasLocation W30439550711 @default.
- W3043955071 hasOpenAccess W3043955071 @default.
- W3043955071 hasPrimaryLocation W30439550711 @default.
- W3043955071 hasRelatedWork W1851988028 @default.
- W3043955071 hasRelatedWork W1856368263 @default.
- W3043955071 hasRelatedWork W2010207062 @default.
- W3043955071 hasRelatedWork W2012929170 @default.
- W3043955071 hasRelatedWork W2027537940 @default.
- W3043955071 hasRelatedWork W2104392115 @default.
- W3043955071 hasRelatedWork W2171205951 @default.
- W3043955071 hasRelatedWork W2229261797 @default.
- W3043955071 hasRelatedWork W2564354621 @default.
- W3043955071 hasRelatedWork W2757724694 @default.
- W3043955071 hasRelatedWork W2777098989 @default.
- W3043955071 hasRelatedWork W2791053942 @default.
- W3043955071 hasRelatedWork W2794466266 @default.
- W3043955071 hasRelatedWork W2971812229 @default.
- W3043955071 hasRelatedWork W2984201543 @default.
- W3043955071 hasRelatedWork W3032246542 @default.
- W3043955071 hasRelatedWork W3087215562 @default.
- W3043955071 hasRelatedWork W3128204032 @default.
- W3043955071 hasRelatedWork W3162441626 @default.
- W3043955071 hasRelatedWork W54338882 @default.
- W3043955071 hasVolume "65" @default.
- W3043955071 isParatext "false" @default.
- W3043955071 isRetracted "false" @default.
- W3043955071 magId "3043955071" @default.
- W3043955071 workType "article" @default.