FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3043964092> ?p ?o ?g. }

• W3043964092 endingPage "144971" @default.
• W3043964092 startingPage "144971" @default.
• W3043964092 abstract "Diabetic nephropathy (DN) is a serious microvascular complication of diabetes across the world. Recently, many circular RNAs (circRNAs) can exert a crucial role in DN progression. Our investigation was designed to study whether circ_0123996 was associated with DN and aimed to find out the underlying mechanisms. We observed that circ_0123996 expression was significantly increased in Type 2 diabetes (T2D) with DN in comparison to those patients without DN. Consistently, circ_0123996 was also obviously elevated in DN mice models and high glucose (HG)-incubated MMCs. Then, it was proved transfection of circ_0123996 siRNA in mice mesangial cells (MMCs) restrained MMCs proliferation greatly. In addition, it was demonstrated that decrease of circ_0123996 alleviated fibrosis-related protein expression including FN and Col-4 in MMCs. Next, it was confirmed by our study that circ_0123996 can serve as a sponge for miR-149-5p. miR-149-5p has been identified in several diseases including diabetes. At present, we observed that miR-149-5p was decreased in DN. Overexpression of miR-149-5p greatly repressed the effect of circ_0123996 on MMCs. BTB and CNC homology 1 (Bach1) is reported in various disease including some vascular diseases. Here, Bach1 was confirmed as a target of miR-149-5p. Circ_0123996 upregulated Bach1 expression and restrained MMCs proliferation and fibrosis through sponging miR-149-5p. Thus, it was revealed that circ_0123996 was involved in DN via sponging miR-149-5p and modulating Bach1 expression." @default.
• W3043964092 created "2020-07-29" @default.
• W3043964092 creator A5018393711 @default.
• W3043964092 creator A5020746135 @default.
• W3043964092 creator A5028829344 @default.
• W3043964092 creator A5078055442 @default.
• W3043964092 date "2020-11-01" @default.
• W3043964092 modified "2023-10-17" @default.
• W3043964092 title "Circ_0123996 promotes cell proliferation and fibrosis in mouse mesangial cells through sponging miR-149-5p and inducing Bach1 expression" @default.
• W3043964092 cites W1999575142 @default.
• W3043964092 cites W2041262731 @default.
• W3043964092 cites W2059117644 @default.
• W3043964092 cites W2064621895 @default.
• W3043964092 cites W2291416078 @default.
• W3043964092 cites W2394782024 @default.
• W3043964092 cites W2613179596 @default.
• W3043964092 cites W2737722001 @default.
• W3043964092 cites W2746148759 @default.
• W3043964092 cites W2761040533 @default.
• W3043964092 cites W2883062882 @default.
• W3043964092 cites W2884057849 @default.
• W3043964092 cites W2885229294 @default.
• W3043964092 cites W2888856107 @default.
• W3043964092 cites W2893012608 @default.
• W3043964092 cites W2897326053 @default.
• W3043964092 cites W2914026182 @default.
• W3043964092 cites W2921096313 @default.
• W3043964092 cites W2922119727 @default.
• W3043964092 cites W2943314527 @default.
• W3043964092 cites W2946948719 @default.
• W3043964092 cites W2953959053 @default.
• W3043964092 cites W2991258058 @default.
• W3043964092 cites W2997795180 @default.
• W3043964092 cites W3001443590 @default.
• W3043964092 cites W3007300208 @default.
• W3043964092 cites W4247544731 @default.
• W3043964092 doi "https://doi.org/10.1016/j.gene.2020.144971" @default.
• W3043964092 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32707301" @default.
• W3043964092 hasPublicationYear "2020" @default.
• W3043964092 type Work @default.
• W3043964092 sameAs 3043964092 @default.
• W3043964092 citedByCount "25" @default.
• W3043964092 countsByYear W30439640922020 @default.
• W3043964092 countsByYear W30439640922021 @default.
• W3043964092 countsByYear W30439640922022 @default.
• W3043964092 countsByYear W30439640922023 @default.
• W3043964092 crossrefType "journal-article" @default.
• W3043964092 hasAuthorship W3043964092A5018393711 @default.
• W3043964092 hasAuthorship W3043964092A5020746135 @default.
• W3043964092 hasAuthorship W3043964092A5028829344 @default.
• W3043964092 hasAuthorship W3043964092A5078055442 @default.
• W3043964092 hasConcept C104317684 @default.
• W3043964092 hasConcept C126322002 @default.
• W3043964092 hasConcept C127561419 @default.
• W3043964092 hasConcept C134018914 @default.
• W3043964092 hasConcept C2779922275 @default.
• W3043964092 hasConcept C2780559512 @default.
• W3043964092 hasConcept C502942594 @default.
• W3043964092 hasConcept C54009773 @default.
• W3043964092 hasConcept C54355233 @default.
• W3043964092 hasConcept C55493867 @default.
• W3043964092 hasConcept C555293320 @default.
• W3043964092 hasConcept C62112901 @default.
• W3043964092 hasConcept C71924100 @default.
• W3043964092 hasConcept C81885089 @default.
• W3043964092 hasConcept C86803240 @default.
• W3043964092 hasConceptScore W3043964092C104317684 @default.
• W3043964092 hasConceptScore W3043964092C126322002 @default.
• W3043964092 hasConceptScore W3043964092C127561419 @default.
• W3043964092 hasConceptScore W3043964092C134018914 @default.
• W3043964092 hasConceptScore W3043964092C2779922275 @default.
• W3043964092 hasConceptScore W3043964092C2780559512 @default.
• W3043964092 hasConceptScore W3043964092C502942594 @default.
• W3043964092 hasConceptScore W3043964092C54009773 @default.
• W3043964092 hasConceptScore W3043964092C54355233 @default.
• W3043964092 hasConceptScore W3043964092C55493867 @default.
• W3043964092 hasConceptScore W3043964092C555293320 @default.
• W3043964092 hasConceptScore W3043964092C62112901 @default.
• W3043964092 hasConceptScore W3043964092C71924100 @default.
• W3043964092 hasConceptScore W3043964092C81885089 @default.
• W3043964092 hasConceptScore W3043964092C86803240 @default.
• W3043964092 hasLocation W30439640921 @default.
• W3043964092 hasLocation W30439640922 @default.
• W3043964092 hasOpenAccess W3043964092 @default.
• W3043964092 hasPrimaryLocation W30439640921 @default.
• W3043964092 hasRelatedWork W2026862129 @default.
• W3043964092 hasRelatedWork W2080599553 @default.
• W3043964092 hasRelatedWork W2372521113 @default.
• W3043964092 hasRelatedWork W2592007767 @default.
• W3043964092 hasRelatedWork W2900494214 @default.
• W3043964092 hasRelatedWork W2921528227 @default.
• W3043964092 hasRelatedWork W2996239022 @default.
• W3043964092 hasRelatedWork W3016435787 @default.
• W3043964092 hasRelatedWork W4214698807 @default.
• W3043964092 hasRelatedWork W4327518501 @default.
• W3043964092 hasVolume "761" @default.
• W3043964092 isParatext "false" @default.
• W3043964092 isRetracted "false" @default.

• next