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- W3043974889 abstract "Drug DevelopmentMost drug formulations comprise mainly inactive ingredients known as excipients. Excipients are tested in animal studies and do not display toxicity at allowed concentrations, but their interaction with molecular targets has not been systematically explored. Pottel et al. examined excipient activity by combining large-scale computational screening with targeted experimental testing. They identified 38 excipients with activities against 44 targets. Several excipients were active in cell panels that predict tissue-level toxicity, and two are suggested to reach concentrations in vivo that overlap with their in vitro activities. Although most excipients are inert, some have activity that deserves further consideration.Science , this issue p. [403][1] [1]: /lookup/doi/10.1126/science.aaz9906" @default.
- W3043974889 created "2020-07-29" @default.
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- W3043974889 date "2020-07-23" @default.
- W3043974889 modified "2023-09-25" @default.
- W3043974889 title "Inactive ingredients may not be inert" @default.
- W3043974889 doi "https://doi.org/10.1126/science.369.6502.387-b" @default.
- W3043974889 hasPublicationYear "2020" @default.
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