Matches in SemOpenAlex for { <https://semopenalex.org/work/W3043992493> ?p ?o ?g. }
- W3043992493 endingPage "249" @default.
- W3043992493 startingPage "240" @default.
- W3043992493 abstract "Glutamate (Glu) is a key molecule in cellular metabolism, the most abundant excitatory neurotransmitter in the brain, and the principal neurotransmitter of cortical efferents. Glutamate dysfunction, on the other hand, is common in neurodegenerative disorders, and likely contributes to age-related declines in behavioral and cognitive functioning. Nonetheless, the extant literature measuring age-related changes in brain glutamate in vivo has yet to be comprehensively and quantitatively summarized. This meta-analysis examines proton spectroscopy (1HMRS) measures of Glu-related brain metabolites across 589 healthy young and older adults. Glu (Cohen's d = -0.82) and Glu+glutamine (Cohen's d = -0.51) concentrations were significantly lower in older compared with younger adults, whereas the concentration of glutamine (d = 0.43) was significantly higher in older individuals. Notably, 1HMRS methodological choices impacted effect sizes for age-related Glu differences. Glu metabolite change appears to be a robust marker of aging-related neurological change; however, additional studies are needed to elucidate age-related trajectories of glutamatergic alterations and their relationship to cognitive phenotypes." @default.
- W3043992493 created "2020-07-29" @default.
- W3043992493 creator A5001446136 @default.
- W3043992493 creator A5007238841 @default.
- W3043992493 creator A5011698340 @default.
- W3043992493 creator A5013332746 @default.
- W3043992493 creator A5041082600 @default.
- W3043992493 creator A5041387594 @default.
- W3043992493 creator A5070905064 @default.
- W3043992493 date "2020-11-01" @default.
- W3043992493 modified "2023-10-11" @default.
- W3043992493 title "A quantitative meta-analysis of brain glutamate metabolites in aging" @default.
- W3043992493 cites W1510800683 @default.
- W3043992493 cites W1530841705 @default.
- W3043992493 cites W1540104393 @default.
- W3043992493 cites W1557485257 @default.
- W3043992493 cites W1638218062 @default.
- W3043992493 cites W1749756287 @default.
- W3043992493 cites W1964435302 @default.
- W3043992493 cites W1967097853 @default.
- W3043992493 cites W1972611197 @default.
- W3043992493 cites W1979423827 @default.
- W3043992493 cites W1981729261 @default.
- W3043992493 cites W1990672257 @default.
- W3043992493 cites W1995951019 @default.
- W3043992493 cites W1998855584 @default.
- W3043992493 cites W2000867410 @default.
- W3043992493 cites W2006184706 @default.
- W3043992493 cites W2006546769 @default.
- W3043992493 cites W2007448929 @default.
- W3043992493 cites W2008639041 @default.
- W3043992493 cites W2028756092 @default.
- W3043992493 cites W2033585778 @default.
- W3043992493 cites W2036831413 @default.
- W3043992493 cites W2037366304 @default.
- W3043992493 cites W2046376969 @default.
- W3043992493 cites W2051344348 @default.
- W3043992493 cites W2054973340 @default.
- W3043992493 cites W2059192721 @default.
- W3043992493 cites W2070726080 @default.
- W3043992493 cites W2071818801 @default.
- W3043992493 cites W2075650951 @default.
- W3043992493 cites W2082454730 @default.
- W3043992493 cites W2082703403 @default.
- W3043992493 cites W2084689734 @default.
- W3043992493 cites W2085011598 @default.
- W3043992493 cites W2089202250 @default.
- W3043992493 cites W2090798299 @default.
- W3043992493 cites W2092262854 @default.
- W3043992493 cites W2106625755 @default.
- W3043992493 cites W2107287771 @default.
- W3043992493 cites W2109341296 @default.
- W3043992493 cites W2127421809 @default.
- W3043992493 cites W2144867092 @default.
- W3043992493 cites W2157823046 @default.
- W3043992493 cites W2164257784 @default.
- W3043992493 cites W2168566966 @default.
- W3043992493 cites W2235696070 @default.
- W3043992493 cites W2346663901 @default.
- W3043992493 cites W2580254622 @default.
- W3043992493 cites W2596906495 @default.
- W3043992493 cites W2605629642 @default.
- W3043992493 cites W2610163897 @default.
- W3043992493 cites W2728752284 @default.
- W3043992493 cites W2781629004 @default.
- W3043992493 cites W2804739028 @default.
- W3043992493 cites W2883359435 @default.
- W3043992493 cites W2886464261 @default.
- W3043992493 cites W2896083735 @default.
- W3043992493 cites W2898537938 @default.
- W3043992493 cites W2906903840 @default.
- W3043992493 doi "https://doi.org/10.1016/j.neurobiolaging.2020.07.015" @default.
- W3043992493 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7609608" @default.
- W3043992493 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32866885" @default.
- W3043992493 hasPublicationYear "2020" @default.
- W3043992493 type Work @default.
- W3043992493 sameAs 3043992493 @default.
- W3043992493 citedByCount "28" @default.
- W3043992493 countsByYear W30439924932021 @default.
- W3043992493 countsByYear W30439924932022 @default.
- W3043992493 countsByYear W30439924932023 @default.
- W3043992493 crossrefType "journal-article" @default.
- W3043992493 hasAuthorship W3043992493A5001446136 @default.
- W3043992493 hasAuthorship W3043992493A5007238841 @default.
- W3043992493 hasAuthorship W3043992493A5011698340 @default.
- W3043992493 hasAuthorship W3043992493A5013332746 @default.
- W3043992493 hasAuthorship W3043992493A5041082600 @default.
- W3043992493 hasAuthorship W3043992493A5041387594 @default.
- W3043992493 hasAuthorship W3043992493A5070905064 @default.
- W3043992493 hasBestOaLocation W30439924932 @default.
- W3043992493 hasConcept C126322002 @default.
- W3043992493 hasConcept C15744967 @default.
- W3043992493 hasConcept C169760540 @default.
- W3043992493 hasConcept C169900460 @default.
- W3043992493 hasConcept C170493617 @default.
- W3043992493 hasConcept C2776219046 @default.
- W3043992493 hasConcept C2777477808 @default.
- W3043992493 hasConcept C2779134260 @default.