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- W3044013124 abstract "Nucleic acid sensing is a critical mechanism by which the immune system monitors for pathogen invasion. A set of germline-encoded innate immune receptors detect microbial DNA in various compartments of the cell, such as endosomes, the cytosol, and the nucleus. Sensing of microbial DNA through these receptors stimulates, in most cases, interferon regulatory factor-dependent type I IFN synthesis followed by JAK/STAT-dependent interferon-stimulated gene expression. In contrast, the detection of DNA in the cytosol by AIM2 assembles a macromolecular complex called the inflammasome, which unleashes the proteolytic activity of a cysteine protease caspase-1. Caspase-1 cleaves and activates the pro-inflammatory cytokines such as IL-1β and IL-18 and a pore-forming protein, gasdermin D, which triggers pyroptosis, an inflammatory form of cell death. Research over the past decade has revealed that AIM2 plays essential roles not only in host defense against pathogens but also in inflammatory diseases, autoimmunity, and cancer in inflammasome-dependent and inflammasome-independent manners. This review discusses the latest advancements in our understanding of AIM2 biology and its functions in health and disease." @default.
- W3044013124 created "2020-07-29" @default.
- W3044013124 creator A5013760778 @default.
- W3044013124 creator A5023346035 @default.
- W3044013124 creator A5024152889 @default.
- W3044013124 creator A5089273761 @default.
- W3044013124 date "2020-07-26" @default.
- W3044013124 modified "2023-10-17" @default.
- W3044013124 title "AIM2 in health and disease: Inflammasome and beyond" @default.
- W3044013124 cites W1484911577 @default.
- W3044013124 cites W1513855753 @default.
- W3044013124 cites W1529674879 @default.
- W3044013124 cites W1611944043 @default.
- W3044013124 cites W1655860314 @default.
- W3044013124 cites W1739883462 @default.
- W3044013124 cites W1805865584 @default.
- W3044013124 cites W1864325817 @default.
- W3044013124 cites W1878755986 @default.
- W3044013124 cites W1882905539 @default.
- W3044013124 cites W1916083974 @default.
- W3044013124 cites W1964253344 @default.
- W3044013124 cites W1966556163 @default.
- W3044013124 cites W1970874432 @default.
- W3044013124 cites W1973288627 @default.
- W3044013124 cites W1973646620 @default.
- W3044013124 cites W1975136966 @default.
- W3044013124 cites W1975152145 @default.
- W3044013124 cites W1977832660 @default.
- W3044013124 cites W1978809200 @default.
- W3044013124 cites W1984632540 @default.
- W3044013124 cites W1985891126 @default.
- W3044013124 cites W1991689544 @default.
- W3044013124 cites W1995744610 @default.
- W3044013124 cites W2009351870 @default.
- W3044013124 cites W2020729600 @default.
- W3044013124 cites W2028536701 @default.
- W3044013124 cites W2028787589 @default.
- W3044013124 cites W2031796413 @default.
- W3044013124 cites W2034940658 @default.
- W3044013124 cites W2037036600 @default.
- W3044013124 cites W2042288276 @default.
- W3044013124 cites W2042816890 @default.
- W3044013124 cites W2043215173 @default.
- W3044013124 cites W2046832808 @default.
- W3044013124 cites W2051317205 @default.
- W3044013124 cites W2055727949 @default.
- W3044013124 cites W2059381041 @default.
- W3044013124 cites W2064512362 @default.
- W3044013124 cites W2068619092 @default.
- W3044013124 cites W2070784293 @default.
- W3044013124 cites W2072118838 @default.
- W3044013124 cites W2073561387 @default.
- W3044013124 cites W2076036982 @default.
- W3044013124 cites W2078850432 @default.
- W3044013124 cites W2079067092 @default.
- W3044013124 cites W2083392874 @default.
- W3044013124 cites W2084998907 @default.
- W3044013124 cites W2087604740 @default.
- W3044013124 cites W2093578280 @default.
- W3044013124 cites W2098854209 @default.
- W3044013124 cites W2100950834 @default.
- W3044013124 cites W2101195902 @default.
- W3044013124 cites W2103260279 @default.
- W3044013124 cites W2104195963 @default.
- W3044013124 cites W2104399564 @default.
- W3044013124 cites W2104722369 @default.
- W3044013124 cites W2113981042 @default.
- W3044013124 cites W2114740264 @default.
- W3044013124 cites W2116337539 @default.
- W3044013124 cites W2118731963 @default.
- W3044013124 cites W2121415703 @default.
- W3044013124 cites W2122204424 @default.
- W3044013124 cites W2122611554 @default.
- W3044013124 cites W2123981936 @default.
- W3044013124 cites W2129374849 @default.
- W3044013124 cites W2130905222 @default.
- W3044013124 cites W2131268111 @default.
- W3044013124 cites W2143102054 @default.
- W3044013124 cites W2145144950 @default.
- W3044013124 cites W2145928184 @default.
- W3044013124 cites W2148657042 @default.
- W3044013124 cites W2156782644 @default.
- W3044013124 cites W2157305255 @default.
- W3044013124 cites W2165892953 @default.
- W3044013124 cites W2166385141 @default.
- W3044013124 cites W2167340762 @default.
- W3044013124 cites W2168863318 @default.
- W3044013124 cites W2171487873 @default.
- W3044013124 cites W2171810840 @default.
- W3044013124 cites W2173379904 @default.
- W3044013124 cites W2175155357 @default.
- W3044013124 cites W2185402392 @default.
- W3044013124 cites W2201964113 @default.
- W3044013124 cites W2204794554 @default.
- W3044013124 cites W2255959994 @default.
- W3044013124 cites W2271290641 @default.
- W3044013124 cites W2289350324 @default.
- W3044013124 cites W2315039805 @default.