Matches in SemOpenAlex for { <https://semopenalex.org/work/W3044013156> ?p ?o ?g. }
- W3044013156 endingPage "6083" @default.
- W3044013156 startingPage "6070" @default.
- W3044013156 abstract "Copper-based bis(hydroxy naphthaldehyde) complex with axial mono aqua-coordination was synthesized and thoroughly characterized by various spectroscopic{IR, UV-vis, EPR}, ESI-Mass and single X-ray crystallographic studies. The single X-ray crystallography of the complex revealed the square pyramidal coordination geometry with P21 space group with axial water molecule ligated to copper centre. The geometry of the complex was further validated by DFT calculations, which was in accordance with other spectroscopic studies. The binding profile of the complex with ct-DNA and tRNA was carried out by employing various biophysical (absorption, fluorescence, circular dichroism, morphological studies) and computational studies (DFT, molecular docking). The experimental results revealed efficient binding of the complex with both ct-DNA and tRNA primarily, via non-covalent interactions. The binding studies Kb and K values revealed 10-fold greater binding affinity of the complex for tRNA as compared to ct-DNA. The in silico molecular docking further validated the interaction of complex within the hydrophobic pocket of ct-DNA and tRNA. The concentration and time dependent cleavage studies of DNA and tRNA were performed by employing gel electrophoresis assay. The cytotoxic activity of the complex was performed on a panel of human cell lines viz., leukemia (K-562), pancreatic (MIA-PA-CA-2), hepatoma (Hep-G2), cervical (HeLa), and breast (MDA-MB-231) by SRB assay. The complex exhibited selectively remarkably good cytotoxic potential on leukemia (K-562), cervical (HeLa) and hepatoma (Hep-G2) cancer cell lines.Communicated by Ramaswamy H. Sarma." @default.
- W3044013156 created "2020-07-29" @default.
- W3044013156 creator A5008301626 @default.
- W3044013156 creator A5009713147 @default.
- W3044013156 creator A5025145085 @default.
- W3044013156 creator A5089665585 @default.
- W3044013156 date "2020-07-25" @default.
- W3044013156 modified "2023-09-25" @default.
- W3044013156 title "RNA-targeted Cu(II)-based potential antitumor drug entity: comprehensive structural, biological {DNA/RNA binding, cleavage, cytotoxicity} and computational studies" @default.
- W3044013156 cites W1852168664 @default.
- W3044013156 cites W1982199500 @default.
- W3044013156 cites W1986451793 @default.
- W3044013156 cites W1998004406 @default.
- W3044013156 cites W1998945486 @default.
- W3044013156 cites W2014625795 @default.
- W3044013156 cites W2018243429 @default.
- W3044013156 cites W2019932858 @default.
- W3044013156 cites W2043211609 @default.
- W3044013156 cites W2053861881 @default.
- W3044013156 cites W2058276221 @default.
- W3044013156 cites W2066681346 @default.
- W3044013156 cites W2073699723 @default.
- W3044013156 cites W2074711360 @default.
- W3044013156 cites W2082875729 @default.
- W3044013156 cites W2093084777 @default.
- W3044013156 cites W2093500137 @default.
- W3044013156 cites W2096847256 @default.
- W3044013156 cites W2126559170 @default.
- W3044013156 cites W2130886644 @default.
- W3044013156 cites W2141522265 @default.
- W3044013156 cites W2142451942 @default.
- W3044013156 cites W2168137891 @default.
- W3044013156 cites W2195992489 @default.
- W3044013156 cites W2275302710 @default.
- W3044013156 cites W2276295104 @default.
- W3044013156 cites W2334138351 @default.
- W3044013156 cites W2335758618 @default.
- W3044013156 cites W2442594675 @default.
- W3044013156 cites W2502698579 @default.
- W3044013156 cites W2539758848 @default.
- W3044013156 cites W2578659244 @default.
- W3044013156 cites W2800785328 @default.
- W3044013156 cites W2802245906 @default.
- W3044013156 cites W2820941669 @default.
- W3044013156 cites W2899671149 @default.
- W3044013156 cites W2916237905 @default.
- W3044013156 cites W2941527377 @default.
- W3044013156 cites W2978016240 @default.
- W3044013156 cites W2981920284 @default.
- W3044013156 cites W2997849937 @default.
- W3044013156 cites W3022873235 @default.
- W3044013156 cites W3035944579 @default.
- W3044013156 cites W49996661 @default.
- W3044013156 doi "https://doi.org/10.1080/07391102.2020.1797535" @default.
- W3044013156 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32715942" @default.
- W3044013156 hasPublicationYear "2020" @default.
- W3044013156 type Work @default.
- W3044013156 sameAs 3044013156 @default.
- W3044013156 citedByCount "8" @default.
- W3044013156 countsByYear W30440131562020 @default.
- W3044013156 countsByYear W30440131562021 @default.
- W3044013156 countsByYear W30440131562022 @default.
- W3044013156 countsByYear W30440131562023 @default.
- W3044013156 crossrefType "journal-article" @default.
- W3044013156 hasAuthorship W3044013156A5008301626 @default.
- W3044013156 hasAuthorship W3044013156A5009713147 @default.
- W3044013156 hasAuthorship W3044013156A5025145085 @default.
- W3044013156 hasAuthorship W3044013156A5089665585 @default.
- W3044013156 hasConcept C104317684 @default.
- W3044013156 hasConcept C109316439 @default.
- W3044013156 hasConcept C133571119 @default.
- W3044013156 hasConcept C151730666 @default.
- W3044013156 hasConcept C153957851 @default.
- W3044013156 hasConcept C159110408 @default.
- W3044013156 hasConcept C175156509 @default.
- W3044013156 hasConcept C185592680 @default.
- W3044013156 hasConcept C202751555 @default.
- W3044013156 hasConcept C2777366897 @default.
- W3044013156 hasConcept C41685203 @default.
- W3044013156 hasConcept C43369102 @default.
- W3044013156 hasConcept C552990157 @default.
- W3044013156 hasConcept C55493867 @default.
- W3044013156 hasConcept C67705224 @default.
- W3044013156 hasConcept C71240020 @default.
- W3044013156 hasConcept C71924100 @default.
- W3044013156 hasConcept C8010536 @default.
- W3044013156 hasConcept C86803240 @default.
- W3044013156 hasConceptScore W3044013156C104317684 @default.
- W3044013156 hasConceptScore W3044013156C109316439 @default.
- W3044013156 hasConceptScore W3044013156C133571119 @default.
- W3044013156 hasConceptScore W3044013156C151730666 @default.
- W3044013156 hasConceptScore W3044013156C153957851 @default.
- W3044013156 hasConceptScore W3044013156C159110408 @default.
- W3044013156 hasConceptScore W3044013156C175156509 @default.
- W3044013156 hasConceptScore W3044013156C185592680 @default.
- W3044013156 hasConceptScore W3044013156C202751555 @default.
- W3044013156 hasConceptScore W3044013156C2777366897 @default.
- W3044013156 hasConceptScore W3044013156C41685203 @default.