FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3044015665> ?p ?o ?g. }

• W3044015665 abstract "Abstract Individuals most often use several rather than one substance among alcohol, cigarettes or cannabis. This widespread co‐occurring use of multiple substances is thought to stem from a common liability that is partly genetic in origin. Genetic risk may indirectly contribute to a common liability to substance use through genetically influenced mental health vulnerabilities and individual traits. To test this possibility, we used polygenic scores indexing mental health and individual traits and examined their association with the common versus specific liabilities to substance use. We used data from the Avon Longitudinal Study of Parents and Children ( N = 4218) and applied trait‐state‐occasion models to delineate the common and substance‐specific factors based on four classes of substances (alcohol, cigarettes, cannabis and other illicit substances) assessed over time (ages 17, 20 and 22). We generated 18 polygenic scores indexing genetically influenced mental health vulnerabilities and individual traits. In multivariable regression, we then tested the independent contribution of selected polygenic scores to the common and substance‐specific factors. Our results implicated several genetically influenced traits and vulnerabilities in the common liability to substance use, most notably risk taking ( b standardised = 0.14; 95% confidence interval [CI] [0.10, 0.17]), followed by extraversion ( b standardised = −0.10; 95% CI [−0.13, −0.06]), and schizophrenia risk ( b standardised = 0.06; 95% CI [0.02, 0.09]). Educational attainment (EA) and body mass index (BMI) had opposite effects on substance‐specific liabilities such as cigarette use ( b standardised‐EA = −0.15; 95% CI [−0.19, −0.12]; b standardised‐BMI = 0.05; 95% CI [0.02, 0.09]) and alcohol use ( b standardised‐EA = 0.07; 95% CI [0.03, 0.11]; b standardised‐BMI = −0.06; 95% CI [−0.10, −0.02]). These findings point towards largely distinct sets of genetic influences on the common versus specific liabilities." @default.
• W3044015665 created "2020-07-29" @default.
• W3044015665 creator A5013110004 @default.
• W3044015665 creator A5021523749 @default.
• W3044015665 creator A5024899825 @default.
• W3044015665 creator A5047142862 @default.
• W3044015665 creator A5062243887 @default.
• W3044015665 creator A5069395807 @default.
• W3044015665 date "2020-07-23" @default.
• W3044015665 modified "2023-09-23" @default.
• W3044015665 title "Identifying risk factors involved in the common versus specific liabilities to substance use: A genetically informed approach" @default.
• W3044015665 cites W1746214591 @default.
• W3044015665 cites W1913957972 @default.
• W3044015665 cites W1957682507 @default.
• W3044015665 cites W1994285916 @default.
• W3044015665 cites W2006057102 @default.
• W3044015665 cites W2028592520 @default.
• W3044015665 cites W2028724567 @default.
• W3044015665 cites W2029087690 @default.
• W3044015665 cites W2035974122 @default.
• W3044015665 cites W2043559838 @default.
• W3044015665 cites W2050206510 @default.
• W3044015665 cites W205085950 @default.
• W3044015665 cites W2055360665 @default.
• W3044015665 cites W2064127542 @default.
• W3044015665 cites W2074338214 @default.
• W3044015665 cites W2092527697 @default.
• W3044015665 cites W2110048796 @default.
• W3044015665 cites W2110052313 @default.
• W3044015665 cites W2110608362 @default.
• W3044015665 cites W2120955617 @default.
• W3044015665 cites W2129413769 @default.
• W3044015665 cites W2132689140 @default.
• W3044015665 cites W2139841657 @default.
• W3044015665 cites W2143509157 @default.
• W3044015665 cites W2145025818 @default.
• W3044015665 cites W2212096717 @default.
• W3044015665 cites W2267449998 @default.
• W3044015665 cites W2328070697 @default.
• W3044015665 cites W2338213945 @default.
• W3044015665 cites W2344070856 @default.
• W3044015665 cites W2400194285 @default.
• W3044015665 cites W2511188271 @default.
• W3044015665 cites W2571516690 @default.
• W3044015665 cites W2771705430 @default.
• W3044015665 cites W2797277859 @default.
• W3044015665 cites W2803316842 @default.
• W3044015665 cites W2804140773 @default.
• W3044015665 cites W2806899908 @default.
• W3044015665 cites W2888416545 @default.
• W3044015665 cites W2909486692 @default.
• W3044015665 cites W2909598358 @default.
• W3044015665 cites W2918465864 @default.
• W3044015665 cites W2928966425 @default.
• W3044015665 cites W2933424604 @default.
• W3044015665 cites W2950317560 @default.
• W3044015665 cites W2951264754 @default.
• W3044015665 cites W2952677689 @default.
• W3044015665 cites W2958498709 @default.
• W3044015665 cites W2965887611 @default.
• W3044015665 cites W2995971356 @default.
• W3044015665 cites W3044015665 @default.
• W3044015665 cites W4255712837 @default.
• W3044015665 doi "https://doi.org/10.1111/adb.12944" @default.
• W3044015665 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8427469" @default.
• W3044015665 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32705754" @default.
• W3044015665 hasPublicationYear "2020" @default.
• W3044015665 type Work @default.
• W3044015665 sameAs 3044015665 @default.
• W3044015665 citedByCount "6" @default.
• W3044015665 countsByYear W30440156652020 @default.
• W3044015665 countsByYear W30440156652021 @default.
• W3044015665 countsByYear W30440156652022 @default.
• W3044015665 countsByYear W30440156652023 @default.
• W3044015665 crossrefType "journal-article" @default.
• W3044015665 hasAuthorship W3044015665A5013110004 @default.
• W3044015665 hasAuthorship W3044015665A5021523749 @default.
• W3044015665 hasAuthorship W3044015665A5024899825 @default.
• W3044015665 hasAuthorship W3044015665A5047142862 @default.
• W3044015665 hasAuthorship W3044015665A5062243887 @default.
• W3044015665 hasAuthorship W3044015665A5069395807 @default.
• W3044015665 hasBestOaLocation W30440156651 @default.
• W3044015665 hasConcept C106934330 @default.
• W3044015665 hasConcept C118552586 @default.
• W3044015665 hasConcept C127816348 @default.
• W3044015665 hasConcept C15744967 @default.
• W3044015665 hasConcept C187288502 @default.
• W3044015665 hasConcept C199360897 @default.
• W3044015665 hasConcept C2777056318 @default.
• W3044015665 hasConcept C2865642 @default.
• W3044015665 hasConcept C41008148 @default.
• W3044015665 hasConcept C70410870 @default.
• W3044015665 hasConcept C71924100 @default.
• W3044015665 hasConcept C77805123 @default.
• W3044015665 hasConceptScore W3044015665C106934330 @default.
• W3044015665 hasConceptScore W3044015665C118552586 @default.
• W3044015665 hasConceptScore W3044015665C127816348 @default.
• W3044015665 hasConceptScore W3044015665C15744967 @default.
• W3044015665 hasConceptScore W3044015665C187288502 @default.
• W3044015665 hasConceptScore W3044015665C199360897 @default.

• next