FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3044034455> ?p ?o ?g. }

• W3044034455 abstract "Numerous studies have identified association between age-related cognitive impairment (CI) and oxidative damage, accumulation of metals, amyloid levels, tau and deranged lipid profile. There is a concerted effort to establish reliability of these blood based biomarkers for predictive diagnosis of CI and its progression. We assessed the serum levels of high density lipoprotein (HDL) cholesterol, low density lipoprotein (LDL) cholesterol, triglycerides, total cholesterol, selected metals (Cu, Al, Zn, Pb, Mn, Cad), and total-tau and amyloid beta-42 protein in mild (n=71), moderate (n=86) and severe (n=25) cognitively impaired patients and compared them with age-matched healthy controls (n=90)from Pakistan. We found that a decrease in HDL cholesterol (correlation coefficient r=0.467) and amyloid beta-42 (r=0.451) were associated with increase severity of CI. On the other hand, an increase in cholesterol ratio (r= -0.562), LDL cholesterol (r= -0.428), triglycerides and total-tau (r= -0.443) were associated with increased severity of CI. Increases in cholesterol ratio showed the strongest association and correlated with increases in tau concentration (r=0.368), and increased triglycerides were associated with decreased amyloid beta-42 (r= -0.345). Increased Cu levels showed the strongest association with tau increase and increased Zn and Pb levels showed the strongest association with reduced amyloid beta-42 levels. Receiver Operating Characteristic (ROC) showed the cutoff values of blood metals (Al, Pb, Cu, Cad, Zn and Mn), total-tau and amyloid beta-42 with sensitivity and specificity. Our data shows for the first time that blood lipids, metals (particularly Cu, Zn, Pb and Al), serum amyloid beta-42/tau proteins modulate each other’s levels and can be collectively used as a predictive marker for CI." @default.
• W3044034455 created "2020-07-29" @default.
• W3044034455 creator A5034960645 @default.
• W3044034455 creator A5058684040 @default.
• W3044034455 creator A5091597392 @default.
• W3044034455 date "2020-07-22" @default.
• W3044034455 modified "2023-10-14" @default.
• W3044034455 title "Blood-Based Biomarkers for Predictive Diagnosis of Cognitive Impairment in a Pakistani Population" @default.
• W3044034455 cites W1507743940 @default.
• W3044034455 cites W1524529327 @default.
• W3044034455 cites W1773591497 @default.
• W3044034455 cites W1847168837 @default.
• W3044034455 cites W1924594419 @default.
• W3044034455 cites W1934350316 @default.
• W3044034455 cites W1936322111 @default.
• W3044034455 cites W1963627192 @default.
• W3044034455 cites W1968226859 @default.
• W3044034455 cites W1975103375 @default.
• W3044034455 cites W1985058290 @default.
• W3044034455 cites W1988322736 @default.
• W3044034455 cites W1993292900 @default.
• W3044034455 cites W1993668532 @default.
• W3044034455 cites W1999620600 @default.
• W3044034455 cites W2007007823 @default.
• W3044034455 cites W2008854521 @default.
• W3044034455 cites W2009111659 @default.
• W3044034455 cites W2014898742 @default.
• W3044034455 cites W2017330669 @default.
• W3044034455 cites W2027220567 @default.
• W3044034455 cites W2036339276 @default.
• W3044034455 cites W2036755018 @default.
• W3044034455 cites W2037500564 @default.
• W3044034455 cites W2041184396 @default.
• W3044034455 cites W2046997729 @default.
• W3044034455 cites W2048810707 @default.
• W3044034455 cites W2054072494 @default.
• W3044034455 cites W2058161128 @default.
• W3044034455 cites W2061082762 @default.
• W3044034455 cites W2061233470 @default.
• W3044034455 cites W2064004368 @default.
• W3044034455 cites W2064126078 @default.
• W3044034455 cites W2077233571 @default.
• W3044034455 cites W2079938040 @default.
• W3044034455 cites W2082431283 @default.
• W3044034455 cites W2083054399 @default.
• W3044034455 cites W2100791808 @default.
• W3044034455 cites W2101800098 @default.
• W3044034455 cites W2103000829 @default.
• W3044034455 cites W2108358846 @default.
• W3044034455 cites W2113472155 @default.
• W3044034455 cites W2114175246 @default.
• W3044034455 cites W2120766938 @default.
• W3044034455 cites W2133025814 @default.
• W3044034455 cites W2140966273 @default.
• W3044034455 cites W2146788881 @default.
• W3044034455 cites W2146978742 @default.
• W3044034455 cites W2148027524 @default.
• W3044034455 cites W2148080316 @default.
• W3044034455 cites W2161737267 @default.
• W3044034455 cites W2162059739 @default.
• W3044034455 cites W2162681653 @default.
• W3044034455 cites W2167311298 @default.
• W3044034455 cites W2169555689 @default.
• W3044034455 cites W2315534203 @default.
• W3044034455 cites W2327547544 @default.
• W3044034455 cites W2598291967 @default.
• W3044034455 cites W2734651019 @default.
• W3044034455 cites W2752042669 @default.
• W3044034455 cites W2782509615 @default.
• W3044034455 cites W2784493975 @default.
• W3044034455 cites W2785233760 @default.
• W3044034455 cites W2793026451 @default.
• W3044034455 cites W2799986334 @default.
• W3044034455 cites W2800116015 @default.
• W3044034455 cites W2891702111 @default.
• W3044034455 cites W2892409381 @default.
• W3044034455 cites W2904163621 @default.
• W3044034455 cites W2904898407 @default.
• W3044034455 cites W2906777561 @default.
• W3044034455 cites W2907076151 @default.
• W3044034455 cites W2911555295 @default.
• W3044034455 cites W2921026105 @default.
• W3044034455 cites W2921224074 @default.
• W3044034455 cites W2937074474 @default.
• W3044034455 cites W2944265914 @default.
• W3044034455 cites W2963728882 @default.
• W3044034455 cites W2965861983 @default.
• W3044034455 cites W2966069945 @default.
• W3044034455 cites W2968841281 @default.
• W3044034455 cites W2971099080 @default.
• W3044034455 cites W3009965961 @default.
• W3044034455 cites W3012537127 @default.
• W3044034455 cites W3014821360 @default.
• W3044034455 cites W3034694470 @default.
• W3044034455 cites W4252142524 @default.
• W3044034455 cites W79036650 @default.
• W3044034455 cites W2888890266 @default.
• W3044034455 doi "https://doi.org/10.3389/fnagi.2020.00223" @default.
• W3044034455 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7396488" @default.
• W3044034455 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32848704" @default.

• next